Ethyl (chlorosulfonyl)acetate supplier

Name
ACETIC ACID
EINECS 200-580-7
CAS No. 55896-93-0
Article Data20
CAS DataBase
Density 1.43 g/cm³
Solubility
Melting Point 16.2 °C(lit.)
Formula C₄H₇ClO₄S
Boiling Point 244.28 °C at 760 mmHg
Molecular Weight 186.616
Flash Point 101.537 °C
Transport Information UN 2790 8/PG 2
Appearance
Safety 23-26-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms Acetic acid,(chlorosulfonyl)-, ethyl ester (9CI);(Chlorosulfonyl)acetic acid ethyl ester;2-(Chlorosulfonyl)acetic acid ethyl ester;Ethoxycarbonylmethanesulfonylchloride;Ethyl 2-(chlorosulfonyl)acetate;Ethyl2-(chlorosulfonyl)ethanoate;
PSA 68.82000
LogP 1.19890

Synthetic route

: 22128-42-3
sodium 2-ethoxy-2-oxoethane-1-sulfonate

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

Conditions

Conditions	Yield
With trichlorophosphate at 80℃; for 2h;	92%
With phosphorus pentachloride at 100℃; for 0.75h; Inert atmosphere;	85%
With phosphorus pentachloride at 20℃; for 0.333333h;	65%

: 89124-45-8
acetic acid ethylester sulfonic acid

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

Conditions

Conditions	Yield
With trichlorophosphate	80%
With thionyl chloride at 120℃;
With trichlorophosphate at 125℃;
With trichlorophosphate
With trichlorophosphate

: 623-51-8
ethyl 2-sulfanylacetate

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

Conditions

Conditions	Yield
With water; chlorine In dichloromethane at 30℃; for 1h; Cooling with acetone-dry ice;	70%

: 105-39-5
chloroacetic acid ethyl ester

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

Conditions

Conditions	Yield
Stage #1: chloroacetic acid ethyl ester With sodium sulfite In ethanol; water for 6h; Heating; Stage #2: With oxalyl dichloride In N,N-dimethyl-formamide; toluene at 100℃; for 3h; Further stages.;	59%

: 64-17-5
ethanol

: 4025-77-8
chlorosulfonylacetyl chloride

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

Conditions

Conditions	Yield
In diethyl ether at 0℃; for 3h; Inert atmosphere;	55%
at -12℃;
In benzene for 1h; Heating;

: 4-(N-methylpiperidin-4-yl)oxy-3-trifluoromethylbenzenamine

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 470477-78-2
ethyl N-[4-(1-methylpiperidin-4-yloxy)-3-trifluoromethylphenyl]sulfamoylacetate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 1h;	100%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: (E)-7-((tert-butyldiphenylsilyl)oxy)hept-4-en-1-ol

: ethyl (E)-2-(((7-((tert-butyldiphenylsilyl)oxy)hept-4-en-1-yl)oxy)sulfonyl)acetate

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 20℃; Inert atmosphere;	100%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 877-80-5
N-methyl-4-nitrobenzylideneamine

: ethyl trans-2-methyl-3-(4-nitrophenyl)-1,2-thiazetidine-4-carboxylate 1,1-dioxide

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 20℃; for 24h; Reagent/catalyst; Staudinger Ketene Cycloaddition; diastereoselective reaction;	99%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 96649-05-7
3-(methoxymethoxy)aniline

: 1049708-54-4
{N-[3-(methoxymethoxy)phenyl]sulfamoyl}acetate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 2.5h;	97%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 122-97-4
3-Phenyl-1-propanol

: 957314-74-8
C13H18O5S

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran	96%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 283603-57-6
(3S,5R)-3,5-Dimethyl-cyclohexanol

: C12H22O5S

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran	96%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: ethyl 2-[(1,2,3,4-tetrahydroquinolin-1-yl)sulfonyl]acetate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 24h;	96%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 2344-70-9, 14786-43-7, 22148-86-3, 39516-03-5
(R)-4-phenyl-2-butanol

: C14H20O5S

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran	95%

: 337520-59-9
4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-dichloroaniline

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 337520-60-2
ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-dichlorophenyl]sulfamoylacetate

Conditions

Conditions	Yield
With pyridine In hexane; dichloromethane; ethyl acetate	95%
With pyridine In dichloromethane

: 7540-51-4
(S)-3,7-dimethyl-6-octen-1-ol

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 1201917-28-3
ethyl (3S)-2-[[(3,7-dimethyl-6-octen-1-yl)oxy]sulfonyl]-acetate

Conditions

Conditions	Yield
With triethylamine	95%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 103-49-1
dibenzylamine

: ethyl 2-(N,N-dibenzylsulfamoyl)acetate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 24h;	95%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 1192-37-6
methylenecyclohexane

: 1354702-92-3
ethyl 3-(1-chlorocyclohexyl)propanoate

Conditions

Conditions	Yield
With di(undecanoyl) peroxide In benzene Inert atmosphere; Reflux;	94%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 927-74-2
1-butyn-4-ol

: C8H12O5S

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran	93%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 540-37-4
p-aminoiodobenzene

: 658709-20-7
(4-iodo-phenylsulfamoyl)-acetic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate; p-aminoiodobenzene With triethylamine In ethyl acetate at 20℃; for 72h; Stage #2: With hydrogenchloride In water; ethyl acetate	92%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 121004-44-2
N-methyl-1-(3-nitrophenyl)methanimine

: ethyl trans-2-methyl-3-(3-nitrophenyl)-1,2-thiazetidine-4-carboxylate 1,1-dioxide

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 20℃; for 24h; Reagent/catalyst; Staudinger Ketene Cycloaddition; diastereoselective reaction;	92%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 40230-24-8
2-amino-4,6-diphenylpyrimidine

: ethyl 2-((4,6-diphenylpyrimidin-2-yl)sulfamoyl)acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate With sodium In tetrahydrofuran at 25℃; for 0.0833333h; Sonication; Green chemistry; Stage #2: 2-amino-4,6-diphenylpyrimidine In tetrahydrofuran at 25℃; for 0.25h; Solvent; Sonication; Green chemistry;	92%
Stage #1: 2-amino-4,6-diphenylpyrimidine With dmap; triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: ethyl 2-(chlorosulfonyl)acetate In dichloromethane at 40℃; Inert atmosphere;	69%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 1226780-87-5
2-amino-4-(4-bromophenyl)-6-(4-bromophenyl)pyrimidine

: ethyl {N-[4,6-bis(4-bromophenyl)pyrimidin-2-yl]sulfamoyl}acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate With sodium In tetrahydrofuran at 25℃; for 0.0833333h; Sonication; Green chemistry; Stage #2: 2-amino-4-(4-bromophenyl)-6-(4-bromophenyl)pyrimidine In tetrahydrofuran at 25℃; for 0.283333h; Sonication; Green chemistry;	92%
Stage #1: 2-amino-4-(4-bromophenyl)-6-(4-bromophenyl)pyrimidine With dmap; triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: ethyl 2-(chlorosulfonyl)acetate In dichloromethane at 40℃; Inert atmosphere;	68%

: 928-92-7
(E)-hex-4-en-1-ol

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: ethyl (E)-2-((hex-4-en-1-yloxy)sulfonyl)acetate

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 20℃; Inert atmosphere;	92%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 13159-16-5
(E)-5-phenyl-4-penten-1-ol

: ethyl (E)-2-(((5-phenylpent-4-en-1-yl)oxy)sulfonyl)acetate

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 20℃; Inert atmosphere;	92%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 2104-09-8
4-(4-nitro-phenyl)-thiazol-2-ylamine

: ethyl {N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]sulfamoyl}acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate With sodium In tetrahydrofuran at 25℃; for 0.0833333h; Sonication; Green chemistry; Stage #2: 4-(4-nitro-phenyl)-thiazol-2-ylamine In tetrahydrofuran at 25℃; for 0.216667h; Sonication; Green chemistry;	92%

: 626-89-1
4-Methyl-1-pentanol

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: C10H20O5S

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran	91%

: 111-66-0
oct-1-ene

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 1354702-90-1
ethyl 4-chlorodecanoate

Conditions

Conditions	Yield
With di(undecanoyl) peroxide In benzene Inert atmosphere; Reflux;	91%

: 2010-06-2
2-Amino-4-phenylthiazole

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: ethyl [N-(4-phenyl-1,3-thiazol-2-yl)sulfamoyl]acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate With sodium In tetrahydrofuran at 25℃; for 0.0833333h; Sonication; Green chemistry; Stage #2: 2-Amino-4-phenylthiazole In tetrahydrofuran at 25℃; for 0.316667h; Sonication; Green chemistry;	91%
Stage #1: 2-Amino-4-phenylthiazole With dmap; triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: ethyl 2-(chlorosulfonyl)acetate In dichloromethane at 40℃; Inert atmosphere;	72%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: C16H11N5O4

: ethyl {N-[4,6-bis(4-nitrophenyl)pyrimidin-2-yl]sulfamoyl}acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate With sodium In tetrahydrofuran at 25℃; for 0.0833333h; Sonication; Green chemistry; Stage #2: C16H11N5O4 In tetrahydrofuran at 25℃; for 0.316667h; Sonication; Green chemistry;	91%
Stage #1: C16H11N5O4 With dmap; triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: ethyl 2-(chlorosulfonyl)acetate In dichloromethane at 40℃; Inert atmosphere;	70%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 60472-20-0
4-(4-methoxyphenyl)-1H-imidazol-2-ylamine

: ethyl {N-[4-(4-methoxyphenyl)-1H-imidazol-2-yl]sulfamoyl}acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate With sodium In tetrahydrofuran at 25℃; for 0.0833333h; Sonication; Green chemistry; Stage #2: 4-(4-methoxyphenyl)-1H-imidazol-2-ylamine In tetrahydrofuran at 25℃; for 0.25h; Sonication; Green chemistry;	91%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 2216-51-5
(-)-menthol

: C14H26O5S

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran	90%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 141-78-6
ethyl acetate

: 337520-13-5
4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-ethoxycarbonylaniline

: 337520-14-6
ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-ethoxycarbonylphenyl]sulfamoylacetate

Conditions

Conditions	Yield
With pyridine In hexane; dichloromethane	90%

...Expand

: 2103-99-3
4-(4-chlorophenyl)-2-thiazolamine

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: ethyl {N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]sulfamoyl}acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate With sodium In tetrahydrofuran at 25℃; for 0.0833333h; Sonication; Green chemistry; Stage #2: 4-(4-chlorophenyl)-2-thiazolamine In tetrahydrofuran at 25℃; for 0.333333h; Sonication; Green chemistry;	90%
Stage #1: 4-(4-chlorophenyl)-2-thiazolamine With dmap; triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: ethyl 2-(chlorosulfonyl)acetate In dichloromethane at 40℃; Inert atmosphere;	75%

: 55896-93-0
ethyl 2-(chlorosulfonyl)acetate

: 6775-40-2
2-amino-4-phenylimidazole

: ethyl 2-((4-phenyl-1H-imidazol-2-yl)sulfamoyl)acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(chlorosulfonyl)acetate With sodium In tetrahydrofuran at 25℃; for 0.0833333h; Sonication; Green chemistry; Stage #2: 2-amino-4-phenylimidazole In tetrahydrofuran at 25℃; for 0.25h; Sonication; Green chemistry;	90%
Stage #1: 2-amino-4-phenylimidazole With dmap; triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: ethyl 2-(chlorosulfonyl)acetate In dichloromethane at 40℃; Inert atmosphere;	71%
With dmap; triethylamine In dichloromethane

Ethyl (chlorosulfonyl)acetate Chemical Properties

Product Name: Ethyl (chlorosulfonyl)acetate (CAS NO.55896-93-0)

Molecular Formula: C₄H₇ClO₄S
Molecular Weight: 186.614g/mol
Mol File: 55896-93-0.mol
Boiling point: 244.28 °C at 760 mmHg
Flash Point: 101.537 °C
Density: 1.43 g/cm³
Surface Tension: 44.87 dyne/cm
Enthalpy of Vaporization: 48.133 kJ/mol
Vapour Pressure: 0.031 mmHg at 25°C

Product Name

ACETIC ACID

Synthetic route

Ethyl (chlorosulfonyl)acetate Chemical Properties

Related Products

Hot Products