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Hanzhong TRG Biotech Co.,Ltd.

Plant Description Epimedium is a pungent ornamental herb found in Asia and the Mediterranean. The Chinese call epimedium Yin Yang Huo, which loosely means "licentious goat plant.". Epimedium species are hardy perennials. The majority have

Epimedium extract - Icariins 10%

Cas:489-32-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xian Changyue Biological Technology Co., Ltd.

Pharmacological action: effects on sex function, effects on microorganisms, cough, expectoration and asthma Main functions: immune system, anti-aging, cardiovascular, blood function, metabolism and osteoporosis. Our Advantages: 1. Free samples and

Weihai Moochun Bio-Tech Co., Ltd.

details: Icariin: 5%~98% HPLC Icariins: 5%~60% HPLC Total Flavone:10%~30% UV physical & chemic character: appearance: brown powder loss on drying: ≤5% ash: ≤3% mesh size: 100% pass80 mesh

Epimedium Grandiflorum Extract 489-32-7

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $65.0 / 70.0

Type:Trading Company

inquiry

Greenutra Resource Inc

Epimedium Grandiflorum Extract Icariin Latin Name: Epimedium Brevicornum Maxim CAS NO.: 489-32-7 Specification: Icariin5%,10%,20%,40%,50%,60%,98% Active Ingredient: Icariin; Icariins Molecular Formula: C33H40O15

EpimediumGrandiflorum Extract Icariin

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $32.0

Type:Trading Company

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DB BIOTECH CO., LTD

Quick Details Type: Herbal Extract Variety: Epimedium Extract Form: Powder Part: leaf Extraction Type: Solvent Extraction

High quality Icariin in bulk supply

Cas:489-32-7

Min.Order:1 Gram

FOB Price: $25.0 / 2000.0

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Why Choose Us 1. Quality Price We are the manufacturer, so we can provide the competitive price and high quality product. 2. Packing Products could be packaged according to customer's specializedrequirements. 3. Transport The products can be tr

High Purity Natural Horny Goat Weed Extract Icariin Epimedium Extract Powder 98% CAS 489-32-7

Cas:489-32-7

Min.Order:1000 Kilogram

FOB Price: $70.0 / 75.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Brown powder Storage:R.T Package:25kg/drum Application:Chemical raw material Transportation:Express/Sea/Air Port:Any port in China

10% 20% 98% Icariin cas 489-32-7

Cas:489-32-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Icariin

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% factory price Epimedium P.E. Epimedium leaf extract

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $5.0 / 800.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Test Result Test Methods Icariin ≥20.0% 20.10% HPLC Appe

High purity Various Specifications Icariin CAS:489-32-7

Cas:489-32-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Icariin(Shorthorned Epimedium P.E.) supplier in China

Cas:489-32-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Superiority pioneerbiotech is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best q

Manufacturer Top Quality Icariin powder

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $800.0 / 3000.0

Type:Other

inquiry

Hubei Vanz Pharm Co.,Ltd

Product advantage: Guaranteed quality Good pice Well packed Service advantage: Pre-sale service 1. Technical consultancy, to help customer know about the properties, features, quality, production and supply of the product they wa

Bulk supply Epimedium extract Icariin 10% 50% 98% for sexual enhancement

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $130.0 / 160.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Icariin with high quality

Cas:489-32-7

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Light yellow fine powder Storage:cool dry place Package:100g/1kg/foil bag Application:medicine raw material Transp

Manufacturer high quality Shorthorned Epimedium Powder Extract Cas 489-32-7 with good price

Cas:489-32-7

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Sexual Herbal Icariin Pure Natural Epimedium Extract Icariin 10% Xi'an Quanao Biotech Co., Ltd. is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additiv

Sexual Herbal Icariin Pure Natural Epimedium Extract Icariin 10%

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $175.0 / 185.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Icariin(Shorthorned Epimedium P.E.)

Cas:489-32-7

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Icariin 489-32-7 ISO Producer

Cas:489-32-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Icariin

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Icariin

Cas:489-32-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name: Epimedium breviconum P.E. Alias:Icariin; Epimedium extract; Epimedium extract; And Mr Glycosides English Name:Epimedium breviconum P.E. CSA:489-32-7 Molecular formula:C33H40O15 Molecular weight:676.66 Packaging Specification: 25kg/drum

Epimedium breviconum P.E./CAS:489-32-7/Manufacturer provides straightly

Cas:489-32-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Icariin

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Icariin CAS:489-32-7 MF: C33H40O15 Appearance:Yellow Powder Storage:Store in cool and dry place, away from sun light. Package:25KG Application: it is mainly used as pharmaceutical materail to treat asthenia of kidney, impotence, spermatorrhe

Icariin CAS:489-32-7

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Icariin

Cas:489-32-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 489-32-7 with fast shipping

Cas:489-32-7

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material steroid hormones CAS489-32-7 Icariin anti-aging

Cas:489-32-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Icariin/ LIDE PHARMA- Factory supply / Best price

Cas:489-32-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Pure Icariin 50% 60% 80% 98% Epimedium Extract/Epimedium Sagittatum Extract Powder/Icariin

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

Type:Herbal Extract Variety:Epimedium Extract Form:Powder Part:whole plant Extraction Type:Solvent Extraction Grade:Top Grade Latin name:Epimedium grandiflorum Specifications 100% Natural product, without any Synthetic ing

High quality Epimedium P.E. 98% Icariin

Cas:489-32-7

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Manufacturer Supply pure Epimedium Extract 99% Epimedium Extract Powder Epimedium Extract Price

Cas:489-32-7

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Synthetic route

3-O-(2′′′′,3′′′′,4′′′′-tri-O-acetyl-α-L-rhamnopyranosyl)-7-O-(2′′′,3′′′,4′′′,6′′′-tetra-O-acetyl-β-D-glucopyranosyl)icaritin

3-O-(2′′′′,3′′′′,4′′′′-tri-O-acetyl-α-L-rhamnopyranosyl)-7-O-(2′′′,3′′′,4′′′,6′′′-tetra-O-acetyl-β-D-glucopyranosyl)icaritin

icariin
489-32-7

icariin

Conditions
ConditionsYield
With ammonia In methanol at 20℃; for 3h;94%
UDP-glucose
133-89-1

UDP-glucose

icariside II
113558-15-9

icariside II

icariin
489-32-7

icariin

Conditions
ConditionsYield
With 7-O-glucosyltransferase from Epimedium pseudowushanense In dimethyl sulfoxide at 30℃; for 12h; pH=7.4; Kinetics; Catalytic behavior; Reagent/catalyst; Temperature; pH-value; Green chemistry; Enzymatic reaction; regiospecific reaction;32.8%
7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4Hchromen-4-one

7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4Hchromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
2: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
3: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
4: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
5: ammonia / methanol / 3 h / 20 °C
View Scheme
7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
2: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
3: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
4: ammonia / methanol / 3 h / 20 °C
View Scheme
icaritin
118525-40-9

icaritin

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
2: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
3: ammonia / methanol / 3 h / 20 °C
View Scheme
7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
2: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
3: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
4: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
5: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
6: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
7: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
8: ammonia / methanol / 3 h / 20 °C
View Scheme
3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one
16274-11-6

3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: potassium iodide; potassium carbonate / acetone
2: dimethyl sulfate; potassium carbonate / acetone
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
4: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
5: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
6: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
7: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
8: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
9: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
10: ammonia / methanol / 3 h / 20 °C
View Scheme
7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
2: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
3: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
4: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
5: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
6: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
7: ammonia / methanol / 3 h / 20 °C
View Scheme
kaempferol
520-18-3

kaempferol

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: pyridine
2: potassium iodide; potassium carbonate / acetone
3: dimethyl sulfate; potassium carbonate / acetone
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
5: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
6: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
7: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
8: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
9: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
10: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
11: ammonia / methanol / 3 h / 20 °C
View Scheme
2-(4-acetoxyphenyl)-7-(benzyloxy)-4-oxo-4H-chromene-3,5-diyl diacetate

2-(4-acetoxyphenyl)-7-(benzyloxy)-4-oxo-4H-chromene-3,5-diyl diacetate

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: dimethyl sulfate; potassium carbonate / acetone
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
3: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
4: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
5: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
6: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
7: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
8: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
9: ammonia / methanol / 3 h / 20 °C
View Scheme
7-(benzyloxy)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-5-((3-methylbut-2-en-1-yl)oxy)-4Hchromen-4-one

7-(benzyloxy)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-5-((3-methylbut-2-en-1-yl)oxy)-4Hchromen-4-one

icariin
489-32-7

icariin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
2: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
3: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
4: silver carbonate / chloroform; N,N-dimethyl-formamide / 30 h / 20 °C / Molecular sieve; Darkness; Inert atmosphere
5: silver(l) oxide / dichloromethane / 32 h / Molecular sieve; Inert atmosphere
6: ammonia / methanol / 3 h / 20 °C
View Scheme
C39H48O19

C39H48O19

icariin
489-32-7

icariin

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 50℃; for 0.333333h; Temperature;6 mg
icariin
489-32-7

icariin

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With water; sodium acetate; cellulase In ethanol; water; dimethyl sulfoxide at 37℃; pH=5.0;100%
With cellulase
Multi-step reaction with 2 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
View Scheme
icariin
489-32-7

icariin

icariside II
113558-15-9

icariside II

Conditions
ConditionsYield
With Cunninghamella blakesleana In methanol for 120h; Microbiological reaction; regioselective reaction;95.1%
With cellulase In dimethyl sulfoxide at 37℃; pH=5.7; Enzymatic reaction;84%
With β-glucanase; sodium acetate In aq. buffer at 50℃; for 5h; Enzymatic reaction;79%
icariin
489-32-7

icariin

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one
38226-86-7

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one

Conditions
ConditionsYield
With sulfuric acid; water In methanol for 2h; Reflux;86%
With sulfuric acid; water In 1,4-dioxane for 24h; Reflux;23%
icariin
489-32-7

icariin

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin
56725-99-6

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin

Conditions
ConditionsYield
With sulfuric acid In ethanol; water at 50℃; for 24h;60%
With rhamnosidase In aq. phosphate buffer at 60℃; for 24h; pH=6.8; Enzymatic reaction;1.3 g
With sulfuric acid In ethanol; water at 50℃; for 24h;450 mg
icariin
489-32-7

icariin

sodium ((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxytetrahydro-6-methyl-2H-pyran-2-yl)oxy)-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl sulfate

sodium ((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxytetrahydro-6-methyl-2H-pyran-2-yl)oxy)-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl sulfate

Conditions
ConditionsYield
With pyridine; sulfur trioxide pyridine complex Inert atmosphere;22%
acetic anhydride
108-24-7

acetic anhydride

icariin
489-32-7

icariin

3-O-(2′′′′,3′′′′,4′′′′-tri-O-acetyl-α-L-rhamnopyranosyl)-7-O-(2′′′,3′′′,4′′′,6′′′-tetra-O-acetyl-β-D-glucopyranosyl)icaritin

3-O-(2′′′′,3′′′′,4′′′′-tri-O-acetyl-α-L-rhamnopyranosyl)-7-O-(2′′′,3′′′,4′′′,6′′′-tetra-O-acetyl-β-D-glucopyranosyl)icaritin

Conditions
ConditionsYield
Stage #1: icariin With triethylamine In N,N-dimethyl-formamide for 0.166667h; Cooling with ice;
Stage #2: acetic anhydride In N,N-dimethyl-formamide for 6h; Cooling with ice;
15%
1,6,8-trihydroxy-3-methyl-9,10-anthraquinone
518-82-1

1,6,8-trihydroxy-3-methyl-9,10-anthraquinone

icariin
489-32-7

icariin

A

anthraglycoside B
23313-21-5

anthraglycoside B

B

icariside II
113558-15-9

icariside II

Conditions
ConditionsYield
With glycosyltransferase from Carthamus tinctorius (L.) (Honghua) recombinant; UDP; Cleland's reagent In aq. buffer at 30℃; for 12h; pH=7.4; Enzymatic reaction; regiospecific reaction;A 26 %Chromat.
B 24 %Chromat.
icariin
489-32-7

icariin

C27H30O11

C27H30O11

Conditions
ConditionsYield
With cell suspension cultures of Glycyrrhiza uralensis In N,N-dimethyl-formamide for 168h; Microbiological reaction; regioselective reaction;
icariin
489-32-7

icariin

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromene-3-yl)oxy)methyl)phosphonic acid

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromene-3-yl)oxy)methyl)phosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
4: 2,6-dimethylpyridine; trimethylsilyl bromide / dichloromethane / 20 °C / Inert atmosphere
View Scheme
icariin
489-32-7

icariin

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromen-3-yl)oxy)methyl)phosphonate disodium

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromen-3-yl)oxy)methyl)phosphonate disodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
4: 2,6-dimethylpyridine; trimethylsilyl bromide / dichloromethane / 20 °C / Inert atmosphere
5: sodium methylate / methanol / 0.5 h / 20 °C / Cooling with ice
View Scheme
icariin
489-32-7

icariin

6(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4Η-chromene-3,7-diyl)bis(oxy))bis(methyl))bis(phosphonic acid diethyl ester)

6(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4Η-chromene-3,7-diyl)bis(oxy))bis(methyl))bis(phosphonic acid diethyl ester)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
View Scheme
icariin
489-32-7

icariin

(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)oxo-4Η-chromene-3,7-diyl)bis(oxy))bis(methylene))bisphosphonate sodium

(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)oxo-4Η-chromene-3,7-diyl)bis(oxy))bis(methylene))bisphosphonate sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
4: 2,6-dimethylpyridine; trimethylsilyl bromide / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
5: sodium hydroxide / methanol / 0.5 h
View Scheme
icariin
489-32-7

icariin

(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromene-3,7-diyl)bis(oxy))bis(methylene))bisphosphonic acid

(((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromene-3,7-diyl)bis(oxy))bis(methylene))bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
4: 2,6-dimethylpyridine; trimethylsilyl bromide / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
View Scheme
icariin
489-32-7

icariin

(2S)-2-((((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en1-yl)-4-oxo-4H-chromen-3-yl)oxy)(ethoxy)phosphoryl)amino)-3-methylbutanoate

(2S)-2-((((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en1-yl)-4-oxo-4H-chromen-3-yl)oxy)(ethoxy)phosphoryl)amino)-3-methylbutanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: triethylamine; dmap / dichloromethane / 49 h / 0 - 20 °C
View Scheme
icariin
489-32-7

icariin

2-((((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl)oxy)(ethoxy)phosphoryl)amino)acetic acid ethyl ester

2-((((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl)oxy)(ethoxy)phosphoryl)amino)acetic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: triethylamine; dmap / dichloromethane / 49 h / 0 - 20 °C
View Scheme
icariin
489-32-7

icariin

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromen-3-yl)oxy)methyl)phosphonate diethyl ester

(((5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-ene-1-yl)-4-oxo-4H-chromen-3-yl)oxy)methyl)phosphonate diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
3: caesium carbonate / acetone / Inert atmosphere; Reflux
View Scheme
icariin
489-32-7

icariin

C55H69NO22

C55H69NO22

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / Cooling with ice
1.2: 6 h / Cooling with ice
2.1: potassium carbonate; potassium iodide / acetone / 0.17 h
2.2: 20 °C
3.1: potassium carbonate; potassium iodide / acetone / 0.17 h / 20 °C
3.2: 0.5 h / 20 °C
View Scheme
icariin
489-32-7

icariin

C50H59BrO22

C50H59BrO22

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / Cooling with ice
1.2: 6 h / Cooling with ice
2.1: potassium carbonate; potassium iodide / acetone / 0.17 h
2.2: 20 °C
View Scheme
malonic acid
141-82-2

malonic acid

icariin
489-32-7

icariin

8-prenylkaempferol-4'-methylether-3-O-rhamnoside-7-O-(6-O-malonyl)-β-D-glucopyranoside

8-prenylkaempferol-4'-methylether-3-O-rhamnoside-7-O-(6-O-malonyl)-β-D-glucopyranoside

Conditions
ConditionsYield
With DL-dithiothreitol; MatB from Arabidopsis thaliana; NbMaT1; ATP; magnesium chloride; Coenzyme A In aq. phosphate buffer at 30℃; for 12h; pH=7.5; Enzymatic reaction;
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