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icariin
icaritin
Conditions | Yield |
---|---|
With water; sodium acetate; cellulase In ethanol; water; dimethyl sulfoxide at 37℃; pH=5.0; | 100% |
With cellulase | |
Multi-step reaction with 2 steps 1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction 2: sulfuric acid / ethanol; water / 5 h / 50 °C View Scheme |
icaritin
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 2h; Reflux; Inert atmosphere; | 96% |
icaritin
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 65℃; for 1h; Inert atmosphere; | 95% |
icaritin
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 60℃; | 87% |
With sodium hydroxide In ethanol; water at 60℃; | 87% |
icaritin
Conditions | Yield |
---|---|
With cyclohexa-1,4-diene; palladium 10% on activated carbon In methanol at 20℃; for 2h; | 86% |
With cyclohexa-1,4-diene; palladium 10% on activated carbon In methanol at 20℃; for 2h; | 84% |
icariside II
icaritin
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; water at 50℃; for 5h; | 82% |
With sulfuric acid In ethanol; water at 50℃; for 5h; | 82% |
With sulfuric acid In ethanol; water at 50℃; for 5h; | 82% |
icaritin
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; isopropyl alcohol for 6.16667h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux; | 70.6% |
3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin
icaritin
Conditions | Yield |
---|---|
With cellulase In dimethyl sulfoxide at 37℃; pH=5.7; | 68% |
Conditions | Yield |
---|---|
With sulfuric acid In methanol |
icaritin
Conditions | Yield |
---|---|
With sulfuric acid | |
With potassium hydroxide |
Conditions | Yield |
---|---|
With potassium hydroxide |
4'-methoxy-5-hydroxy-8-3,3-dimethylallylflavone 3-O-β-D-glucopyranosyl(1<*>2)α-L-rhamnopyranoside-7-O-β-D-glucopyranoside
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: β-glucosidase 2: 1 N H2SO4 / methanol View Scheme |
A
icaritin
B
icariside II
C
3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin
Conditions | Yield |
---|---|
With hydrogenchloride; methanol; water at 80℃; for 8h; Product distribution / selectivity; Heating / reflux; | |
With sodium methylate In pyridine at 80℃; for 8h; Product distribution / selectivity; Heating / reflux; | |
With acetic acid; β-glucuronidase; naringinase; hesperidinase; β-galactosidase; cellulase; amyloglucosidase at 37℃; for 48h; pH=4.5; Product distribution / selectivity; | |
Stage #1: epimedium koreanum Nakai, leaves; 1-butanol-ether-hexane-methanol extract of With water at 121℃; for 0.5h; Stage #2: at 30℃; for 120h; Product distribution / selectivity; |
A
icaritin
B
3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin
Conditions | Yield |
---|---|
With sulfuric acid; water In ethanol for 1.5h; Reflux; |
4-methoxybenzoic acid
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: thionyl chloride / dichloromethane / 4 h / Reflux 2.1: potassium carbonate / acetone / 24.5 h / 65 °C 3.1: sodium carbonate; sodium hydrogencarbonate; Oxone / acetone; water; dichloromethane / 29 h / 0 °C / pH 9 3.2: 2 h / 20 °C 4.1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C 5.1: potassium carbonate / acetone / 6 h / 20 °C 6.1: potassium carbonate / acetone / 12 h / 50 °C 7.1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation 8.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere View Scheme |
4-hydroxy-benzoic acid
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: sodium hydroxide / water / 4 h / 40 °C 2.1: thionyl chloride / dichloromethane / 4 h / Reflux 3.1: potassium carbonate / acetone / 24.5 h / 65 °C 4.1: sodium carbonate; sodium hydrogencarbonate; Oxone / acetone; water; dichloromethane / 29 h / 0 °C / pH 9 4.2: 2 h / 20 °C 5.1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C 6.1: potassium carbonate / acetone / 6 h / 20 °C 7.1: potassium carbonate / acetone / 12 h / 50 °C 8.1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation 9.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere View Scheme |
4-methoxy-benzoyl chloride
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium carbonate / acetone / 24.5 h / 65 °C 2.1: sodium carbonate; sodium hydrogencarbonate; Oxone / acetone; water; dichloromethane / 29 h / 0 °C / pH 9 2.2: 2 h / 20 °C 3.1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C 4.1: potassium carbonate / acetone / 6 h / 20 °C 5.1: potassium carbonate / acetone / 12 h / 50 °C 6.1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation 7.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium carbonate; sodium hydrogencarbonate; Oxone / acetone; water; dichloromethane / 29 h / 0 °C / pH 9 1.2: 2 h / 20 °C 2.1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C 3.1: potassium carbonate / acetone / 6 h / 20 °C 4.1: potassium carbonate / acetone / 12 h / 50 °C 5.1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation 6.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C 2: potassium carbonate / acetone / 6 h / 20 °C 3: potassium carbonate / acetone / 12 h / 50 °C 4: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation 5: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere View Scheme |
4'-O-methylkaempferol
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / acetone / 6 h / 20 °C 2: potassium carbonate / acetone / 12 h / 50 °C 3: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation 4: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere 2: caesium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 18 h / 10 - 20 °C / Inert atmosphere 3: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere 2: caesium carbonate; tetrabutylammomium bromide / tetrahydrofuran / 40 h / 30 °C / Inert atmosphere 3: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 12 h / 50 °C 2: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation 3: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: caesium carbonate; tetrabutylammomium bromide / tetrahydrofuran / 40 h / 30 °C / Inert atmosphere 2: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 3 steps 1: caesium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 18 h / 10 - 20 °C / Inert atmosphere 2: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation 2: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere 2: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux 2: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C 2: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C 3: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere 4: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere 5: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C 2: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C 3: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere 4: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux 5: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme |
3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: potassium iodide; potassium carbonate / acetone 2: dimethyl sulfate; potassium carbonate / acetone 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C 4: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C 5: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere 6: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere 7: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / Reflux 2.1: potassium carbonate / tetrahydrofuran / 2 h / Reflux 2.2: 24 h / Reflux 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C 4.1: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C 5.1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere 6.1: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux 7.1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C 2: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere 3: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere 4: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C 2: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere 3: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux 4: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme |
kaempferol
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: pyridine 2: potassium iodide; potassium carbonate / acetone 3: dimethyl sulfate; potassium carbonate / acetone 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C 5: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C 6: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere 7: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere 8: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: pyridine / 20 °C 2.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / Reflux 3.1: potassium carbonate / tetrahydrofuran / 2 h / Reflux 3.2: 24 h / Reflux 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C 5.1: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C 6.1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere 7.1: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux 8.1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: dimethyl sulfate; potassium carbonate / acetone 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C 3: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C 4: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere 5: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere 6: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: potassium carbonate / tetrahydrofuran / 2 h / Reflux 1.2: 24 h / Reflux 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C 3.1: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C 4.1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere 5.1: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux 6.1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere 2: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere 3: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere 2: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux 3: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C View Scheme |
icaritin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium acetate; hydrogenchloride / ethanol; water / 5 h / 50 °C / pH 5 / Enzymatic reaction 2: sulfuric acid / ethanol; water / 5 h / 50 °C View Scheme |
formic acid
icaritin
3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one
Conditions | Yield |
---|---|
for 20h; Reflux; | 93.3% |
icaritin
3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one
Conditions | Yield |
---|---|
With sulfuric acid; acetic acid at 90℃; for 6h; | 92% |
With sulfuric acid; acetic acid at 90℃; for 6h; | 92% |
With polyphosphoric acid; air In N,N-dimethyl-formamide at 130℃; for 2h; | 81% |
icaritin
ethyl bromoacetate
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Reflux; | 90% |
1,4-dibromo-butane
icaritin
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 12h; Reflux; | 87% |
Conditions | Yield |
---|---|
With recombinant rhamnosyl transferase from Epimedium pseudowushanense; UDP-rhamnose synthase from Epimedium pseudowushanense; nicotinamide adenine dinucleotide; NADPH In dimethyl sulfoxide at 30℃; for 12h; pH=7.4; Enzymatic reaction; regioselective reaction; | 87% |
Conditions | Yield |
---|---|
Stage #1: N-Boc-(S/R)-valine; icaritin With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h; Stage #2: With hydrogenchloride In dichloromethane; water at 20℃; for 0.333333h; | 81% |
4-bromoethylbutanoate
icaritin
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Reflux; | 80% |
N-t-butyloxycarbonyl-DL-alanine
icaritin
Conditions | Yield |
---|---|
Stage #1: N-t-butyloxycarbonyl-DL-alanine; icaritin With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h; Stage #2: With hydrogenchloride In dichloromethane; water at 20℃; for 0.333333h; | 80% |
icaritin
ethyl iodoacetae
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 12h; Reflux; | 79% |
1 ,6-dibromohexane
icaritin
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 12h; Reflux; | 78% |
1,8-dibromooctane
icaritin
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 12h; Reflux; | 75% |
icaritin
2-bromoethanol
5-hydroxy-3,7-bis(2-hydroxyethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Reflux; | 73% |
With potassium carbonate In acetone Reflux; | 61% |
With potassium carbonate In acetone Reflux; | 61% |
Conditions | Yield |
---|---|
Stage #1: bis(trichloromethyl) carbonate; icaritin With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere; Stage #2: 1-methyl-piperazine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; | 69% |
icaritin
ethyl iodoacetae
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 12h; Reflux; | 65% |
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; tetrachloromethane at -10 - 20℃; | 64% |
4-bromo-trans-crotonic acid ethyl ester
icaritin
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Reflux; | 60% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; | 59.8% |
icaritin
1-bromo-3-propanol
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Reflux; | 55% |
With potassium carbonate In acetone at 56℃; for 8h; | 850 mg |
icaritin
2-Bromoethyl methyl ether
Conditions | Yield |
---|---|
With potassium carbonate In acetone Reflux; Inert atmosphere; | 55% |
icaritin
ethylene dibromide
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 12h; Reflux; | 54% |
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Reflux; | A 41% B 12% |
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Reflux; | A 40% B 10% |
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