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Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma

Icaritin/Anhydroicaritin

Cas:118525-40-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Why Choose Us 1. Quality Price We are the manufacturer, so we can provide the competitive price and high quality product. 2. Packing Products could be packaged according to customer's specializedrequirements. 3. Transport The products can be tr

98%min Icaritin CAS 118525-40-9 with good quality

Cas:118525-40-9

Min.Order:1000 Kilogram

FOB Price: $70.0 / 75.0

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Icaritin Manufacturer/High quality/Best price/In stock

Cas:118525-40-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Icaritin Cas 118525-40-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Light yellow powder Storage:Store in 2-8℃ Package:10g,100g,1kg/foil bag Appli

High purity Icaritin Cas 118525-40-9 with factory best price

Cas:118525-40-9

Min.Order:10 Gram

FOB Price: $15.0 / 45.0

Type:Trading Company

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract Anhydroicaritin HACCP manufacturer

Cas:118525-40-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Icaritin

Cas:118525-40-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Anhydroicaritin

Cas:118525-40-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Icaritin CAS No. 118525-40-9

Cas:118525-40-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 118525-40-9 with competitive price

Cas:118525-40-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Icaritin 118525-40-9

Cas:118525-40-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

ICARITIN WITH BEST PRICE

Cas:118525-40-9

Min.Order:1 Gram

FOB Price: $42.0 / 45.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Icaritin CAS:118525-40-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Icaritin CAS:118525-40-9

Cas:118525-40-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Icaritin

Cas:118525-40-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

best price,best quality and fast delivery assurance available in sample product and customization with years of export experience along with excellent quality, advanced services and competitive prices the quality of products conform u

99.0% Icaritin CAS:118525-40-9 CAS NO.118525-40-9

Cas:118525-40-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Icaritin

Cas:118525-40-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3,7-bis(2-hydroxyethyl)icaritin

Cas:118525-40-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/A

Anhydroicaritin

Cas:118525-40-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Icaritin

Cas:118525-40-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Icaritin

Cas:118525-40-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Xinhao Biotechnology Co., Ltd.

1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .

Icaritin Manufacturer/High quality/Best price/In stock CAS NO.118525-40-9

Cas:118525-40-9

Min.Order:100 Gram

FOB Price: $10.0 / 100.0

Type:Trading Company

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us 1. Quality Price We are the manufacturer, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. Packing Products could be packaged according to customer&#

Icaritin

Cas:118525-40-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

SHENGZHIKAI TECHNOLOGY INDUSTRY CO., LTD

Natural product : 100% natural product, without any synthetic ingredients. Manufacturer : China's leading manufacturer of plant extracts. Quality : Our products have undergone comprehensive inspection and all have passed strict testing. In s

with good quality Icaritin CAS 118525-40-9 with factory best price CAS NO.118525-40-9

Cas:118525-40-9

Min.Order:5 Gram

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Icaritin

Cas:118525-40-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Changer pharmatech Co.,Ltd

Our products are strictly tested in quality, and the price is more favorable in the same industry. Capacity of production:Ranging from gram level to hundred-kilogram level Partnership: we have maintained long-term cooperation with many well-known p

ICARITIN

Cas:118525-40-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3,7-bis(2-hydroxyethyl)icaritin

Cas:118525-40-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferIcaritin

Cas:118525-40-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Icaritin

Cas:118525-40-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Icaritin 99%

Cas:118525-40-9

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3,7-bis(2-hydroxyethyl)icaritin

Cas:118525-40-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Icaritin

Cas:118525-40-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

icariin
489-32-7

icariin

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With water; sodium acetate; cellulase In ethanol; water; dimethyl sulfoxide at 37℃; pH=5.0;100%
With cellulase
Multi-step reaction with 2 steps
1: β-glucanase; sodium acetate / aq. buffer / 5 h / 50 °C / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
View Scheme
5-hydroxy-3,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-4H-chromen-4-one

5-hydroxy-3,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-4H-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With hydrogenchloride In methanol for 2h; Reflux; Inert atmosphere;96%
5,7-dimethoxymethyl icaritin

5,7-dimethoxymethyl icaritin

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 65℃; for 1h; Inert atmosphere;95%
C28H24O7

C28H24O7

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 60℃;87%
With sodium hydroxide In ethanol; water at 60℃;87%
7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With cyclohexa-1,4-diene; palladium 10% on activated carbon In methanol at 20℃; for 2h;86%
With cyclohexa-1,4-diene; palladium 10% on activated carbon In methanol at 20℃; for 2h;84%
icariside II
113558-15-9

icariside II

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With sulfuric acid In ethanol; water at 50℃; for 5h;82%
With sulfuric acid In ethanol; water at 50℃; for 5h;82%
With sulfuric acid In ethanol; water at 50℃; for 5h;82%
C25H28O8

C25H28O8

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; isopropyl alcohol for 6.16667h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux;70.6%
3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin
56725-99-6

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With cellulase In dimethyl sulfoxide at 37℃; pH=5.7;68%
sagittatoside A
118525-35-2

sagittatoside A

A

D-Glucose
2280-44-6

D-Glucose

B

L-rhamnose
6014-42-2

L-rhamnose

C

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With sulfuric acid In methanol
icariside-II

icariside-II

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
With sulfuric acid
With potassium hydroxide
icariside-I

icariside-I

A

icaritin
118525-40-9

icaritin

B

IC-163
521-45-9

IC-163

Conditions
ConditionsYield
With potassium hydroxide
4'-methoxy-5-hydroxy-8-3,3-dimethylallylflavone 3-O-β-D-glucopyranosyl(1<*>2)α-L-rhamnopyranoside-7-O-β-D-glucopyranoside
110623-72-8

4'-methoxy-5-hydroxy-8-3,3-dimethylallylflavone 3-O-β-D-glucopyranosyl(1<*>2)α-L-rhamnopyranoside-7-O-β-D-glucopyranoside

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: β-glucosidase
2: 1 N H2SO4 / methanol
View Scheme
epimedium koreanum Nakai, leaves; 1-butanol-ether-hexane-methanol extract of

epimedium koreanum Nakai, leaves; 1-butanol-ether-hexane-methanol extract of

A

icaritin
118525-40-9

icaritin

B

icariside II
113558-15-9

icariside II

C

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin
56725-99-6

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin

Conditions
ConditionsYield
With hydrogenchloride; methanol; water at 80℃; for 8h; Product distribution / selectivity; Heating / reflux;
With sodium methylate In pyridine at 80℃; for 8h; Product distribution / selectivity; Heating / reflux;
With acetic acid; β-glucuronidase; naringinase; hesperidinase; β-galactosidase; cellulase; amyloglucosidase at 37℃; for 48h; pH=4.5; Product distribution / selectivity;
Stage #1: epimedium koreanum Nakai, leaves; 1-butanol-ether-hexane-methanol extract of With water at 121℃; for 0.5h;
Stage #2: at 30℃; for 120h; Product distribution / selectivity;
3-O-L-rhamnose-7-O-β-glucose-8-prenyl-4'-methoxychrysin

3-O-L-rhamnose-7-O-β-glucose-8-prenyl-4'-methoxychrysin

A

icaritin
118525-40-9

icaritin

B

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin
56725-99-6

3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin

Conditions
ConditionsYield
With sulfuric acid; water In ethanol for 1.5h; Reflux;
4-methoxybenzoic acid
100-09-4

4-methoxybenzoic acid

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: thionyl chloride / dichloromethane / 4 h / Reflux
2.1: potassium carbonate / acetone / 24.5 h / 65 °C
3.1: sodium carbonate; sodium hydrogencarbonate; Oxone / acetone; water; dichloromethane / 29 h / 0 °C / pH 9
3.2: 2 h / 20 °C
4.1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C
5.1: potassium carbonate / acetone / 6 h / 20 °C
6.1: potassium carbonate / acetone / 12 h / 50 °C
7.1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation
8.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere
View Scheme
4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: sodium hydroxide / water / 4 h / 40 °C
2.1: thionyl chloride / dichloromethane / 4 h / Reflux
3.1: potassium carbonate / acetone / 24.5 h / 65 °C
4.1: sodium carbonate; sodium hydrogencarbonate; Oxone / acetone; water; dichloromethane / 29 h / 0 °C / pH 9
4.2: 2 h / 20 °C
5.1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C
6.1: potassium carbonate / acetone / 6 h / 20 °C
7.1: potassium carbonate / acetone / 12 h / 50 °C
8.1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation
9.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere
View Scheme
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetone / 24.5 h / 65 °C
2.1: sodium carbonate; sodium hydrogencarbonate; Oxone / acetone; water; dichloromethane / 29 h / 0 °C / pH 9
2.2: 2 h / 20 °C
3.1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C
4.1: potassium carbonate / acetone / 6 h / 20 °C
5.1: potassium carbonate / acetone / 12 h / 50 °C
6.1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation
7.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere
View Scheme
5,7-bis(benzyloxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

5,7-bis(benzyloxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium carbonate; sodium hydrogencarbonate; Oxone / acetone; water; dichloromethane / 29 h / 0 °C / pH 9
1.2: 2 h / 20 °C
2.1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C
3.1: potassium carbonate / acetone / 6 h / 20 °C
4.1: potassium carbonate / acetone / 12 h / 50 °C
5.1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation
6.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere
View Scheme
5,7-bis(benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

5,7-bis(benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 5%-palladium/activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 20 °C
2: potassium carbonate / acetone / 6 h / 20 °C
3: potassium carbonate / acetone / 12 h / 50 °C
4: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation
5: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere
View Scheme
4'-O-methylkaempferol
491-54-3

4'-O-methylkaempferol

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 6 h / 20 °C
2: potassium carbonate / acetone / 12 h / 50 °C
3: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation
4: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere
2: caesium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 18 h / 10 - 20 °C / Inert atmosphere
3: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere
2: caesium carbonate; tetrabutylammomium bromide / tetrahydrofuran / 40 h / 30 °C / Inert atmosphere
3: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux
View Scheme
5-hydroxy-3,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

5-hydroxy-3,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / 12 h / 50 °C
2: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation
3: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate; tetrabutylammomium bromide / tetrahydrofuran / 40 h / 30 °C / Inert atmosphere
2: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere
3: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 18 h / 10 - 20 °C / Inert atmosphere
2: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere
3: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux
View Scheme
5-(3-methylbut-2-enyloxy)-3,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

5-(3-methylbut-2-enyloxy)-3,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-diethylaniline / 0.5 h / 190 °C / Microwave irradiation
2: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: europium(III) trifluoromethanesulfonate / dichloromethane / 2 h / -5 - 0 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 6.17 h / Inert atmosphere; Reflux
View Scheme
7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4Hchromen-4-one

7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4Hchromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
2: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux
2: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
2: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
3: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
4: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
5: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
2: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C
3: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere
4: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux
5: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one
16274-11-6

3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium iodide; potassium carbonate / acetone
2: dimethyl sulfate; potassium carbonate / acetone
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
4: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
5: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
6: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
7: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / Reflux
2.1: potassium carbonate / tetrahydrofuran / 2 h / Reflux
2.2: 24 h / Reflux
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
4.1: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C
5.1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere
6.1: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux
7.1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

7-(benzyloxy)-5-hydroxy-3-(methoxymethoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
2: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
3: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
4: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C
2: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere
3: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux
4: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
kaempferol
520-18-3

kaempferol

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: pyridine
2: potassium iodide; potassium carbonate / acetone
3: dimethyl sulfate; potassium carbonate / acetone
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
5: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
6: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
7: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
8: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: pyridine / 20 °C
2.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / Reflux
3.1: potassium carbonate / tetrahydrofuran / 2 h / Reflux
3.2: 24 h / Reflux
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
5.1: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C
6.1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere
7.1: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux
8.1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
2-(4-acetoxyphenyl)-7-(benzyloxy)-4-oxo-4H-chromene-3,5-diyl diacetate

2-(4-acetoxyphenyl)-7-(benzyloxy)-4-oxo-4H-chromene-3,5-diyl diacetate

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: dimethyl sulfate; potassium carbonate / acetone
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C
3: 18-crown-6 ether; potassium carbonate / acetone / 19.33 h / 20 °C
4: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
5: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
6: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / tetrahydrofuran / 2 h / Reflux
1.2: 24 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
3.1: potassium carbonate; 18-crown-6 ether / acetone / 19 h / 20 °C
4.1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere
5.1: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux
6.1: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
7-(benzyloxy)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-5-((3-methylbut-2-en-1-yl)oxy)-4Hchromen-4-one

7-(benzyloxy)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-5-((3-methylbut-2-en-1-yl)oxy)-4Hchromen-4-one

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) / chlorobenzene / 24 h / 85 °C / Inert atmosphere
2: hydrogenchloride / methanol; water / 2.5 h / Reflux; Inert atmosphere
3: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); sodium hydrogencarbonate / chlorobenzene / 24 h / 85 °C / Inert atmosphere
2: hydrogenchloride; water / methanol / 2.5 h / Inert atmosphere; Reflux
3: palladium 10% on activated carbon; cyclohexa-1,4-diene / methanol / 2 h / 20 °C
View Scheme
icariin

icariin

icaritin
118525-40-9

icaritin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate; hydrogenchloride / ethanol; water / 5 h / 50 °C / pH 5 / Enzymatic reaction
2: sulfuric acid / ethanol; water / 5 h / 50 °C
View Scheme
formic acid
64-18-6

formic acid

icaritin
118525-40-9

icaritin

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one
38226-86-7

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one

Conditions
ConditionsYield
for 20h; Reflux;93.3%
icaritin
118525-40-9

icaritin

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one
38226-86-7

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-8H-pyrano[2,3-f]chromen-4-one

Conditions
ConditionsYield
With sulfuric acid; acetic acid at 90℃; for 6h;92%
With sulfuric acid; acetic acid at 90℃; for 6h;92%
With polyphosphoric acid; air In N,N-dimethyl-formamide at 130℃; for 2h;81%
icaritin
118525-40-9

icaritin

ethyl bromoacetate
105-36-2

ethyl bromoacetate

2,2'-[(5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3,7-di-yl)bis(oxy)]diacetic acid ethyl ester

2,2'-[(5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3,7-di-yl)bis(oxy)]diacetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Reflux;90%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

icaritin
118525-40-9

icaritin

3,7-bis(4-bromobutoxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

3,7-bis(4-bromobutoxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 12h; Reflux;87%
C15H24N2O17P2

C15H24N2O17P2

icaritin
118525-40-9

icaritin

icariside II
113558-15-9

icariside II

Conditions
ConditionsYield
With recombinant rhamnosyl transferase from Epimedium pseudowushanense; UDP-rhamnose synthase from Epimedium pseudowushanense; nicotinamide adenine dinucleotide; NADPH In dimethyl sulfoxide at 30℃; for 12h; pH=7.4; Enzymatic reaction; regioselective reaction;87%
icaritin
118525-40-9

icaritin

C31H38N2O8*2ClH

C31H38N2O8*2ClH

Conditions
ConditionsYield
Stage #1: N-Boc-(S/R)-valine; icaritin With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h;
Stage #2: With hydrogenchloride In dichloromethane; water at 20℃; for 0.333333h;
81%
4-bromoethylbutanoate
2969-81-5

4-bromoethylbutanoate

icaritin
118525-40-9

icaritin

4,4'-[(5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3,7-diyl)bis(oxy)]dibutyric acid ethyl ester

4,4'-[(5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3,7-diyl)bis(oxy)]dibutyric acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Reflux;80%
N-t-butyloxycarbonyl-DL-alanine
3744-87-4, 7764-95-6, 15761-38-3

N-t-butyloxycarbonyl-DL-alanine

icaritin
118525-40-9

icaritin

C27H30N2O8*2ClH

C27H30N2O8*2ClH

Conditions
ConditionsYield
Stage #1: N-t-butyloxycarbonyl-DL-alanine; icaritin With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h;
Stage #2: With hydrogenchloride In dichloromethane; water at 20℃; for 0.333333h;
80%
icaritin
118525-40-9

icaritin

ethyl iodoacetae
623-48-3

ethyl iodoacetae

2,2'-[(5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3,7-di-yl)bis(oxy)]diacetic acid ethyl ester

2,2'-[(5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3,7-di-yl)bis(oxy)]diacetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone for 12h; Reflux;79%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

icaritin
118525-40-9

icaritin

3,7-bis[(6-bromohexyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

3,7-bis[(6-bromohexyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 12h; Reflux;78%
1,8-dibromooctane
4549-32-0

1,8-dibromooctane

icaritin
118525-40-9

icaritin

3,7-bis[(8-bromooctyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

3,7-bis[(8-bromooctyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 12h; Reflux;75%
icaritin
118525-40-9

icaritin

2-bromoethanol
540-51-2

2-bromoethanol

5-hydroxy-3,7-bis(2-hydroxyethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
1067198-74-6

5-hydroxy-3,7-bis(2-hydroxyethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Reflux;73%
With potassium carbonate In acetone Reflux;61%
With potassium carbonate In acetone Reflux;61%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

icaritin
118525-40-9

icaritin

5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-(chromen-3-yl)-4-methylpiperazin-1-carboxylic acid ester

5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-(chromen-3-yl)-4-methylpiperazin-1-carboxylic acid ester

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; icaritin With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;
Stage #2: 1-methyl-piperazine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
69%
icaritin
118525-40-9

icaritin

ethyl iodoacetae
623-48-3

ethyl iodoacetae

2-[(3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl)oxy]acetic acid ethyl ester

2-[(3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl)oxy]acetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone for 12h; Reflux;65%
icaritin
118525-40-9

icaritin

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

C25H29O9P

C25H29O9P

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; tetrachloromethane at -10 - 20℃;64%
4-bromo-trans-crotonic acid ethyl ester
37746-78-4

4-bromo-trans-crotonic acid ethyl ester

icaritin
118525-40-9

icaritin

4,4'-[(5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3,7-diyl)bis(oxy)]dicrotonic acid ethyl ester

4,4'-[(5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3,7-diyl)bis(oxy)]dicrotonic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Reflux;60%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

icaritin
118525-40-9

icaritin

C26H28O8

C26H28O8

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;59.8%
icaritin
118525-40-9

icaritin

1-bromo-3-propanol
627-18-9

1-bromo-3-propanol

5-hydroxy-3,7-bis(3-hydroxypropoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

5-hydroxy-3,7-bis(3-hydroxypropoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Reflux;55%
With potassium carbonate In acetone at 56℃; for 8h;850 mg
icaritin
118525-40-9

icaritin

2-Bromoethyl methyl ether
6482-24-2

2-Bromoethyl methyl ether

5,7-dihydroxy-3-(2-methoxyethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

5,7-dihydroxy-3-(2-methoxyethoxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone Reflux; Inert atmosphere;55%
icaritin
118525-40-9

icaritin

ethylene dibromide
106-93-4

ethylene dibromide

3,7-bis(2-bromoethoxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

3,7-bis(2-bromoethoxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 12h; Reflux;54%
icaritin
118525-40-9

icaritin

ethyl bromoacetate
105-36-2

ethyl bromoacetate

A

2-[(5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl)oxy]acetic acid ethyl ester

2-[(5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl)oxy]acetic acid ethyl ester

B

2-[(3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl)oxy]acetic acid ethyl ester

2-[(3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl)oxy]acetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Reflux;A 41%
B 12%
icaritin
118525-40-9

icaritin

Ethyl 2-bromopropionate
535-11-5, 41978-69-2

Ethyl 2-bromopropionate

A

2-[(5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl)oxy]propionic acid ethyl ester

2-[(5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl)oxy]propionic acid ethyl ester

B

2-[(3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl)oxy]propionic acid ethyl ester

2-[(3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl)oxy]propionic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Reflux;A 40%
B 10%

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