Ethyl bromopyruvate supplier

Name
Ethyl bromopyruvate
EINECS 200-729-6
CAS No. 70-23-5
Article Data25
CAS DataBase
Density 1.561 g/cm³
Solubility
Melting Point 79 - 82oC
Formula C₅H₇BrO₃
Boiling Point 224.3 °C at 760 mmHg
Molecular Weight 195.013
Flash Point 75.4°C
Transport Information UN 3265
Appearance Clear yellow to pink-red liquid
Safety 26-36-24/25
Risk Codes 36/37/38-33-23/24
Molecular Structure
Hazard Symbols Xi, T
Synonyms Pyruvic acid,bromo-, ethyl ester (6CI,7CI,8CI);3-Bromo-2-(oxo)propionic acid ethyl ester;3-Bromo-2-oxopropanoic acid ethyl ester;3-Bromopyruvic acid ethyl ester;Bromopyruvic acid ethyl ester;Ethyl 3-bromo-2-oxopropanoate;Ethyl3-bromo-2-oxopropionate;Ethyl 3-bromopyruvate;NSC 62182;b-Bromopyruvic acid ethyl ester;
PSA 43.37000
LogP 0.51350

Synthetic route

: 617-35-6
2-oxo-propionic acid ethyl ester

: 70-23-5
ethyl Bromopyruvate

Conditions

Conditions	Yield
With tetrachloromethane; bromine at 50 - 60℃; unter Durchleiten von trockener Luft und Belichtung;
With bromine at 50 - 60℃;
With bromine at 65℃; unter Durchleiten von CO2;

: 56-23-5
tetrachloromethane

: 128-08-5
N-Bromosuccinimide

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

A: 617-35-6
2-oxo-propionic acid ethyl ester

B: 70-23-5
ethyl Bromopyruvate

...Expand

: 547-64-8
methyl lactate

: 70-23-5
ethyl Bromopyruvate

Conditions

Conditions	Yield
With tetrachloromethane; N-Bromosuccinimide

: 14214-10-9
ethyl diazopyruvate

A: 1113-59-3
bromopyruvic acid

B: 70-23-5
ethyl Bromopyruvate

Conditions

Conditions	Yield
With diethyl ether; hydrogen bromide

: 56-23-5
tetrachloromethane

: 128-08-5
N-Bromosuccinimide

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

calcium carbonate: calcium carbonate

A: 617-35-6
2-oxo-propionic acid ethyl ester

B: 70-23-5
ethyl Bromopyruvate

...Expand

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

: 70-23-5
ethyl Bromopyruvate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-bromo-succinimide; calcium carbonate; tetrachloromethane 2: N-bromo-succinimide; tetrachloromethane; hydrogen bromide View Scheme

: 64-17-5
ethanol

: 1113-59-3
bromopyruvic acid

: 70-23-5
ethyl Bromopyruvate

Conditions

Conditions	Yield
hydrogenchloride In water at 30 - 40℃; for 9h;

: 70-23-5
ethyl Bromopyruvate

: 17356-08-0
thiourea

: 5398-36-7
2-aminothiazole-4-carboxylate

Conditions

Conditions	Yield
In ethanol at 70℃; for 1h;	100%
In ethanol at 70℃; for 1h; Hantzsch Thiazole Synthesis;	100%
at 120℃; for 0.5h;	99.5%

: 719-80-2
Ethyl diphenylphosphinite

: 70-23-5
ethyl Bromopyruvate

: 130742-47-1
diphenylphosphinicoenolpyruvate d'ethyle

Conditions

Conditions	Yield
Ambient temperature;	100%

: 70-23-5
ethyl Bromopyruvate

: 73956-15-7
2,2-diethoxythioacetamide

: 73956-16-8
ethyl 2-(diethoxymethyl)-1,3-thiazole-4-carboxylate

Conditions

Conditions	Yield
With 3 A molecular sieve In ethanol for 0.5h; Heating;	100%
With 4 A molecular sieve In ethanol for 1h; Hantzsch reaction; Heating;	100%
With 4 Angstroem MS In ethanol for 1h; Heating;	100%

: 70-23-5
ethyl Bromopyruvate

: 1638-86-4
diethyl phenylphosphonite

: 130742-45-9
2-(Ethoxy-phenyl-phosphinoyloxy)-acrylic acid ethyl ester

Conditions

Conditions	Yield
Ambient temperature;	100%

: 70-23-5
ethyl Bromopyruvate

: 5470-11-1
hydroxylamine hydrochloride

: 127033-04-9
ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate

Conditions

Conditions	Yield
In methanol; chloroform for 16h; Ambient temperature;	100%

: 70-23-5
ethyl Bromopyruvate

: 868-59-7
L-cysteine ethyl ester hydrochloride

: 94110-58-4
diethyl (R)-3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%

: 70-23-5
ethyl Bromopyruvate

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 81095-88-7
ethyl α-(benzyloximino)-β-bromopropanoate

Conditions

Conditions	Yield
In methanol; chloroform for 16h; Ambient temperature;	100%

: 70-23-5
ethyl Bromopyruvate

: 96929-02-1
(S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester

: 96929-07-6
2-<(S)-1--2-methylpropyl>-4-carbethoxythiazole

Conditions

Conditions	Yield
Stage #1: (S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester With potassium hydrogencarbonate In 1,2-dimethoxyethane at -15℃; for 0.333333h; Inert atmosphere; Stage #2: ethyl Bromopyruvate In 1,2-dimethoxyethane at -15 - 20℃; for 0.75h; Inert atmosphere; Stage #3: With 2,6-dimethylpyridine; trifluoroacetic anhydride In 1,2-dimethoxyethane at -15 - 20℃; for 13.5h; Inert atmosphere;	100%
Stage #1: ethyl Bromopyruvate; (S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester With potassium hydrogencarbonate In 1,2-dimethoxyethane at -15℃; Hantzsch reaction; Stage #2: With 2,3,5-trimethyl-pyridine; trifluoroacetic anhydride at -15℃; Hantzsch reaction;	78%
In diethyl ether for 48h; Ambient temperature;	42%

: 70-23-5
ethyl Bromopyruvate

: 73472-94-3
ethyl 3-bromo-2-(hydroxyimino)propanoate

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In chloroform; water at 23℃;	100%
With hydroxyammonium sulfate In chloroform; water at 20℃; for 3h;	95%
With hydroxylamine	88%

: 70-23-5
ethyl Bromopyruvate

: 504-02-9
1,3-cylohexanedione

: 128428-59-1
3-hydroxy-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With potassium hydroxide In methanol Ambient temperature; overnight;	100%
With 1-butyl-3-methylimidazolium hydroxide at 25 - 30℃; for 0.5h; Feist-Benary reaction;	88%
Stage #1: 1,3-cylohexanedione With ammonium acetate In ethanol; water at 80℃; for 1h; Stage #2: ethyl Bromopyruvate In ethanol; water at 80℃; for 3h;	88%
With sodium hydroxide In methanol for 12h; microwave heating;

: 70-23-5
ethyl Bromopyruvate

: 175276-92-3
2,4-difluorobenzene-1-carbothioamide

: 175276-93-4
ethyl 2-(2,4-difluorophenyl)thiazole-4-carboxylate

Conditions

Conditions	Yield
In ethanol for 3h; Heating / reflux;	100%

: 952723-33-0
C9H14N2O2S2

: 70-23-5
ethyl Bromopyruvate

: C14H18N2O4S2

Conditions

Conditions	Yield
In ethanol for 1h; Hantzsch thiazole synthesis; Heating;	100%

: 952723-33-0
C9H14N2O2S2

: 70-23-5
ethyl Bromopyruvate

: 190523-39-8
ethyl 2'-formyl-2,4'-bithiazole-4-carboxylate

Conditions

Conditions	Yield
Stage #1: C9H14N2O2S2; ethyl Bromopyruvate In ethanol for 1h; Hantzsch thiazole synthesis; Heating; Stage #2: With hydrogenchloride In acetone for 1.5h; Heating; Further stages.;	100%

: 625-53-6
ethyl-2-thiourea

: 70-23-5
ethyl Bromopyruvate

: 262372-88-3
2-ethylamino-thiazole-4-carboxylic acid ethyl ester*HBr

Conditions

Conditions	Yield
In 1,4-dioxane Heating / reflux;	100%

: 851581-25-4
2-amino-2-thioxoethyl 5-({[(benzyloxy)carbonyl]amino}methyl)-6-isobutyl-2-methyl-4-(4-methylphenyl)nicotinate

: 70-23-5
ethyl Bromopyruvate

: 851581-26-5
[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]methyl 5-({[(benzyloxy)carbonyl]amino}methyl)-6-isobutyl-2-methyl-4-(4-methylphenyl)nicotinate

Conditions

Conditions	Yield
In ethanol for 1h; Heating / reflux;	100%

: 109-12-6
2-aminopyrimidine

: 70-23-5
ethyl Bromopyruvate

: 149520-94-5
2-amino-1H-imidazole-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 2-aminopyrimidine; ethyl Bromopyruvate In ethanol at 75℃; for 16h; Inert atmosphere; Stage #2: With hydrazine hydrate In ethanol at 75℃; for 16h; Inert atmosphere;	100%
Stage #1: 2-aminopyrimidine; ethyl Bromopyruvate In ethanol at 75℃; Stage #2: With hydrazine hydrate In ethanol at 75℃;	54%
Stage #1: 2-aminopyrimidine; ethyl Bromopyruvate In ethanol at 75℃; for 18h; Stage #2: With hydrazine hydrate In ethanol at 75℃; for 16.5h;	0.34 g

: 70-23-5
ethyl Bromopyruvate

: 698-67-9
p-bromobenzamide

: 391248-23-0
ethyl 2-(4-bromphenyl)-1,3-oxazole-4-carboxylate

Conditions

Conditions	Yield
With silver hexafluoroantimonate In 1,2-dichloro-ethane at 90℃; for 2h; Inert atmosphere; Microwave irradiation;	100%
With silver hexafluoroantimonate In dichloromethane at 90℃; under 3750.38 Torr; for 1h; Sealed tube; Microwave irradiation;
In ethanol at 70℃; for 5h;
Stage #1: ethyl Bromopyruvate; p-bromobenzamide With sodium hydrogencarbonate In tetrahydrofuran at 60℃; for 23h; Stage #2: With trifluoroacetic anhydride In tetrahydrofuran at 20℃; for 12h;

: 10132-07-7
4-amino-2,6-dichloropyrimidine

: 70-23-5
ethyl Bromopyruvate

: ethyl 7-chloro-5-hydroxyimidazo[1,2-c]pyrimidine-2-carboxylate

Conditions

Conditions	Yield
With acetic acid at 120℃; for 2h; Inert atmosphere;	100%
In acetic acid at 120℃; for 2h;	98%

: 563-83-7
ISOPROPYLAMIDE

: 70-23-5
ethyl Bromopyruvate

: 133047-44-6
2-isopropyl-thiazole-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: ISOPROPYLAMIDE With Lawessons reagent In tetrahydrofuran at 70℃; for 24h; Stage #2: ethyl Bromopyruvate In tetrahydrofuran at 70℃; for 48h;	100%

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

: 70-23-5
ethyl Bromopyruvate

: 1121051-30-6
6-bromo-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 16h;	99.5%
In N,N-dimethyl-formamide at 50℃; for 24h;	89%
In N,N-dimethyl-formamide at 50℃; for 24h;	89%

: 2,3,5-tri-O-benzoyl-β-L-(+)-ribofuranosyl-1-thiocarboxamide

: 70-23-5
ethyl Bromopyruvate

: 206269-63-8
Ethyl 2-(2', 3', 5'-Tri-O-benzoyl-β-L(+)-ribofuranosyl)thiazole-4-carboxylate

Conditions

Conditions	Yield
Stage #1: 2,3,5-tri-O-benzoyl-β-L-(+)-ribofuranosyl-1-thiocarboxamide; ethyl Bromopyruvate With sodium hydrogencarbonate In 1,2-dimethoxyethane at 0℃; for 6h; Stage #2: With 2,6-dimethylpyridine; trifluoroacetic anhydride In 1,2-dimethoxyethane at -15℃; for 2h;	99%

: 865604-39-3
2-amino-4-bromo-6-ethoxycarbonylpyridine

: 70-23-5
ethyl Bromopyruvate

: 1021150-13-9
C13H13BrN2O4

Conditions

Conditions	Yield
In ethanol at 60℃;	99%
Stage #1: 2-amino-4-bromo-6-ethoxycarbonylpyridine; ethyl Bromopyruvate In ethanol at 23 - 80℃; for 3h; Stage #2: With sodium hydrogencarbonate In water at 23℃; for 20h;

: 70-23-5
ethyl Bromopyruvate

: 459-05-2
(4-fluoro-phenyl)-thiourea

: ethyl 2-((4-fluorophenyl)amino)thiazole-4-carboxylate

Conditions

Conditions	Yield
In ethanol Reflux;	99%
With sodium carbonate In neat (no solvent) Milling;	80%
In ethanol at 65℃;
In ethanol at 65℃; for 2h;

: 70-23-5
ethyl Bromopyruvate

: 127033-04-9
ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate

Conditions

Conditions	Yield
With hydroxylamine sulfate In chloroform; water at 20℃; for 24h;	99%
With hydroxylamine hydrochloride In methanol; chloroform; water at 25℃; for 22h; Inert atmosphere;	86%
With hydroxyammonium sulfate In chloroform; water at 20℃; for 24h;
With hydroxylamine hydrochloride In water; toluene at 15 - 25℃; Large scale;

: 70-23-5
ethyl Bromopyruvate

: 5-(2,6-dimethylpyridin-4-yl)-2-(methylthio)-6-phenylpyrimidin-4-amine

: ethyl 8-(2,6-dimethylpyridin-4-yl)-5-(methylthio)-7-phenylimidazo[1,2-c]pyrimidine-2-carboxylate

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 110℃; for 2h;	99%

: 70-23-5
ethyl Bromopyruvate

: 603-35-0
triphenylphosphine

: (2-Ethoxycarbonyl-2-oxo-ethyl)-triphenyl-phosphonium; bromide

Conditions

Conditions	Yield
In toluene at 100℃; for 6h; Inert atmosphere;	98.5%
In tetrachloromethane for 36h; Ambient temperature;
In toluene for 3h; Yield given;
In tetrachloromethane at 20℃; for 36h;
With magnetic iron oxide nanoparticles (Fe3O4-MNPs) In neat (no solvent) at 80℃; for 0.75h; Green chemistry;

: 1072-97-5
5-bromo-2-pyridylamine

: 70-23-5
ethyl Bromopyruvate

: 67625-37-0
ethyl 6-bromoimidazo<1,2-a>pyridine-2-carboxylate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In 1,4-dioxane at 100℃; for 12h;	98%
With magnesium sulfate In 1,4-dioxane at 80℃; for 18h;	93%
Stage #1: 5-bromo-2-pyridylamine; ethyl Bromopyruvate In 1,2-dimethoxyethane for 5h; Stage #2: In ethanol Reflux;	87%

: 70-23-5
ethyl Bromopyruvate

: 17356-08-0
thiourea

: 2-amino-4-ethoxycarbonyl-1,3-thiazolehydrobromide

Conditions

Conditions	Yield
In ethyl acetate at 60 - 110℃; Cooling;	98%
In ethanol at 78℃; for 1h;	90%
at 100℃; for 1h;	87%

: 70-23-5
ethyl Bromopyruvate

: 603-35-0
triphenylphosphine

: 1087-09-8
1,4-diphenyl-but-2-yne-1,4-dione

: ethyl 1-benzoyl-6-(bromomethyl)-2,2,2,4-tetraphenyl-3,7-dioxa-2λ5-phosphabicyclo[3.2.0]hept-4-ene-6-carboxylate

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 40h;	98%

...Expand

: 70-23-5
ethyl Bromopyruvate

: 13386-16-8
2,2,2-trideuterio-thioacetamide

: 1443118-25-9
C7H6(2)H3NO2S

Conditions

Conditions	Yield
In d(4)-methanol	98%

Ethyl bromopyruvate Chemical Properties

Molecular structure of Propanoic acid,3-bromo-2-oxo-, ethyl ester (CAS NO.70-23-5) is:

Product Name: Propanoic acid,3-bromo-2-oxo-, ethyl ester
CAS Registry Number: 70-23-5
IUPAC Name: Ethyl 3-bromo-2-oxopropanoate
Molecular Weight: 195.01128 [g/mol]
Molecular Formula: C₅H₇BrO₃
XLogP3-AA: 1.2
H-Bond Donor: 0
H-Bond Acceptor: 3
Refractive index: n20/D 1.469(lit.)
Storage temp.: 2-8 °C
Surface Tension: 39.5 dyne/cm
Density: 1.561 g/cm³
Flash Point: 75.4 °C
Enthalpy of Vaporization: 46.08 kJ/mol
Boiling Point: 224.3 °C at 760 mmHg
Vapour Pressure: 0.0919 mmHg at 25°C
EINECS: 200-729-6
Product Categories: Aromatic Esters;Aliphatics;Esters;C₂ to C₅;Carbonyl Compounds

Ethyl bromopyruvate Safety Profile

Safty information about Propanoic acid,3-bromo-2-oxo-, ethyl ester (CAS NO.70-23-5) is:
Hazard Codes: Irritant Xi; Toxic T
Risk Statements: 36/37/38-33-23/24
R36/37/38:Irritating to eyes, respiratory system and skin.
R33:Danger of cumulative effects.
R23/24:Toxic by inhalation, in contact with skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
RIDADR: 3265
WGK Germany: 3
F: 8-9-21
Hazard Note: Irritant
HazardClass: 8
PackingGroup: II
HS Code: 29183000

Ethyl bromopyruvate Specification

Propanoic acid,3-bromo-2-oxo-, ethyl ester , its cas register number is 70-23-5. It also can be called Ethyl 3-bromopyruvate ; Ethyl bromopyruvate ; beta-Bromopyruvic acid ethyl ester .It is a clear yellow to pink-red liquid with strong offensive odor.

Product Name

Ethyl bromopyruvate

Synthetic route

Ethyl bromopyruvate Chemical Properties

Ethyl bromopyruvate Safety Profile

Ethyl bromopyruvate Specification

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