Product Name

  • Name

    ETHYL OXAZOLE-5-CARBOXYLATE

  • EINECS
  • CAS No. 118994-89-1
  • Article Data15
  • CAS DataBase
  • Density 1.177 g/cm3
  • Solubility Soluble in water (35 g/L at 25°C).
  • Melting Point
  • Formula C6H7NO3
  • Boiling Point 201.966 °C at 760 mmHg
  • Molecular Weight 141.126
  • Flash Point 75.947 °C
  • Transport Information
  • Appearance
  • Safety 26-36/37/39
  • Risk Codes  Xi:Harmful/Irritant/Keep
  • Molecular Structure Molecular Structure of 118994-89-1 (ETHYL OXAZOLE-5-CARBOXYLATE)
  • Hazard Symbols IrritantXi
  • Synonyms Ethyl 1,3-oxazole-5-carboxylate;
  • PSA 52.33000
  • LogP 0.85130

Synthetic route

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2, 36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; toluene at 0℃; for 3h; Inert atmosphere;92%
With potassium carbonate In ethanol at 80℃;86%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; toluene for 3h;80%
methyl isocyanate
593-75-9, 685498-28-6

methyl isocyanate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: methyl isocyanate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.33333h; Metallation;
Stage #2: oxalic acid diethyl ester In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Cyclization;		71%
glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

1-((isocyanomethyl)sulfonyl)-2-methylbenzene

1-((isocyanomethyl)sulfonyl)-2-methylbenzene

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 0℃; Inert atmosphere;
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; toluene at 0℃; for 1.33333h; Inert atmosphere;
methanol
67-56-1

methanol

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2, 36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

A

methyl oxazole-5-carboxylate
121432-12-0

methyl oxazole-5-carboxylate

B

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: methanol; glyoxylic acid ethyl ester With caesium carbonate In tetrahydrofuran at 50℃; for 0.5h;
Stage #2: [(p-methylphenyl)sulfonylmethyl]isonitrile In tetrahydrofuran; acetic acid at 60℃; for 1h;
With caesium carbonate at 60℃;
...Expand
para-bromotoluene
106-38-7

para-bromotoluene

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(p-tolyl)oxazole-5-carboxylate
1037597-71-9

ethyl 2-(p-tolyl)oxazole-5-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;96%
1-(3-Bromophenyl)ethanone
2142-63-4

1-(3-Bromophenyl)ethanone

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(3-acetylphenyl)oxazole-4-carboxylate

ethyl 2-(3-acetylphenyl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;95%
2-methoxy-5-bromopyridine
13472-85-0

2-methoxy-5-bromopyridine

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(6-methoxypyridin-3-yl)oxazole-4-carboxylate

ethyl 2-(6-methoxypyridin-3-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;93%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

Oxazole-5-carboxamide
158178-93-9

Oxazole-5-carboxamide

Conditions
ConditionsYield
In methanol; ammonia liquid NH3;92%
With ammonia In methanol at 20℃; for 2h;92%
In ammonia liquid NH3;92%
With ammonia In methanol at 20℃; for 2h;92%
With ammonia In methanol at 20℃; for 2h;92%
4-bromo-1-(4-methoxybenzyl)-1H-indazole

4-bromo-1-(4-methoxybenzyl)-1H-indazole

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(1-(4-methoxybenzyl)-1H-indazol-4-yl)oxazole-5-carboxylate

ethyl 2-(1-(4-methoxybenzyl)-1H-indazol-4-yl)oxazole-5-carboxylate

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; Trimethylacetic acid; ruphos In toluene at 100℃; for 3h;92%
Benzoylformic acid
611-73-4

Benzoylformic acid

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-benzoyloxazole-5-carboxylate

ethyl 2-benzoyloxazole-5-carboxylate

Conditions
ConditionsYield
With nickel(II) perchlorate hexahydrate; silver carbonate In benzene at 170℃; for 24h;90%
With cobalt(II) perchlorate hexahydrate; silver carbonate at 170℃; for 24h; Sealed tube;62%
2-(4-bromophenyl)-2-(trifluoromethyl)piperidine

2-(4-bromophenyl)-2-(trifluoromethyl)piperidine

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(4-(2-(trifluoromethyl)piperidin-2-yl)phenyl)oxazole-4-carboxylate

ethyl 2-(4-(2-(trifluoromethyl)piperidin-2-yl)phenyl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;90%
4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
1022158-35-5

4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)oxazole-5-carboxylate

ethyl 2-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)oxazole-5-carboxylate

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; Trimethylacetic acid; ruphos In toluene at 100℃; for 18h;89%
5-bromo-2-cyclopropylisoindolin-1-one
864866-56-8

5-bromo-2-cyclopropylisoindolin-1-one

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(2-cyclopropyl-1-oxoisoindolin-5-yl)oxazole-4-carboxylate

ethyl 2-(2-cyclopropyl-1-oxoisoindolin-5-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;89%
1-(tert-butyl) 2-methyl (2S,4R)-4-((4-bromo-7-fluoroisoindoline-2 carbonyl)oxy)pyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (2S,4R)-4-((4-bromo-7-fluoroisoindoline-2 carbonyl)oxy)pyrrolidine-1,2-dicarboxylate

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

1-(tert-butyl) 2-methyl (2S,4R)-4-((4-(4-(ethoxycarbonyl)oxazol-2-yl)-7-fluoroisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (2S,4R)-4-((4-(4-(ethoxycarbonyl)oxazol-2-yl)-7-fluoroisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;89%
1-(4-Methoxyphenyl)-3,3-diethyl-1-triazene
36719-69-4

1-(4-Methoxyphenyl)-3,3-diethyl-1-triazene

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(4-methoxyphenyl)oxazole-5-carboxylate

ethyl 2-(4-methoxyphenyl)oxazole-5-carboxylate

Conditions
ConditionsYield
With copper(l) iodide; palladium diacetate In N,N-dimethyl-formamide at 130℃; for 12h; Sealed tube;88%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

3-Bromo-4-methylpyridin
3430-22-6

3-Bromo-4-methylpyridin

ethyl 2-(4-methylpyridin-3-yl)oxazole-4-carboxylate

ethyl 2-(4-methylpyridin-3-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;88%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

1,3-oxazole-5-carboxylic acid
118994-90-4

1,3-oxazole-5-carboxylic acid

Conditions
ConditionsYield
With lithium hydroxide monohydrate; water at 25℃; for 6.5h; Large scale;87.5%
With lithium hydroxide monohydrate In water at 25℃; for 6.5h; Large scale;87.5%
Stage #1: oxazol-5-yl-carboxylic acid ethyl ester With lithium hydroxide monohydrate In water at 25℃; for 6.5h;
Stage #2: With hydrogenchloride In water at 5 - 25℃; for 1h;		87.4%
With lithium hydroxide In tetrahydrofuran; water at 20℃; for 16h;67%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

5-bromo-2(trifluoromethyl)pyridine
436799-32-5

5-bromo-2(trifluoromethyl)pyridine

ethyl 2-(6-(trifluoromethyl)pyridin-3-yl)oxazole-4-carboxylate

ethyl 2-(6-(trifluoromethyl)pyridin-3-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Sealed tube; Inert atmosphere; Glovebox;87%
benzyl 3-bromo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

benzyl 3-bromo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

C22H21N3O5

C22H21N3O5

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;87%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

1,3-oxazol-5-ylmethanol
127232-41-1

1,3-oxazol-5-ylmethanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.5h;86%
With sodium tetrahydroborate In ethanol at 20℃; for 60h;85%
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; methanol at -10 - 20℃; Inert atmosphere;71%
3,3-diethyl-1-(4-methylphenyl)-1-triazene
36719-51-4

3,3-diethyl-1-(4-methylphenyl)-1-triazene

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(p-tolyl)oxazole-5-carboxylate
1037597-71-9

ethyl 2-(p-tolyl)oxazole-5-carboxylate

Conditions
ConditionsYield
With copper(l) iodide; palladium diacetate In N,N-dimethyl-formamide at 130℃; for 12h; Sealed tube;85%
4-bromo-N,N-dimethyl-1H-indazole-1-sulfonamide

4-bromo-N,N-dimethyl-1H-indazole-1-sulfonamide

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(1-(N,N-dimethylsulfamoyl)-1H-indazol-4-yl)oxazole-5-carboxylate

ethyl 2-(1-(N,N-dimethylsulfamoyl)-1H-indazol-4-yl)oxazole-5-carboxylate

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; Trimethylacetic acid; ruphos In toluene at 100℃; for 3h;85%
5-iodo-2-(trifluoromethyl)pyridine
873107-98-3

5-iodo-2-(trifluoromethyl)pyridine

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(6-(trifluoromethyl)pyridin-3-yl)oxazole-4-carboxylate

ethyl 2-(6-(trifluoromethyl)pyridin-3-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;85%
4-bromo-2-(4-methoxybenzyl)-2H-indazole

4-bromo-2-(4-methoxybenzyl)-2H-indazole

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(2-(4-methoxybenzyl)-2H-indazol-4-yl)oxazole-5-carboxylate

ethyl 2-(2-(4-methoxybenzyl)-2H-indazol-4-yl)oxazole-5-carboxylate

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; Trimethylacetic acid; ruphos In toluene at 100℃; for 3h;84%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

5-bromo-2(trifluoromethyl)pyridine
436799-32-5

5-bromo-2(trifluoromethyl)pyridine

ethyl 2-(6-(trifluoromethyl)pyridin-3-yl)oxazole-5-carboxylate

ethyl 2-(6-(trifluoromethyl)pyridin-3-yl)oxazole-5-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;84%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

ethyl 2-(5-(trifluoromethyl)pyridin-2-yl)oxazole-4-carboxylate

ethyl 2-(5-(trifluoromethyl)pyridin-2-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;84%
N-(tert-butyl)-4’-((6-iodo-4-oxo-2-propylquinazolin-3(4H)-yl)methyl)-[1,1’-biphenyl]-2-sulfonamide

N-(tert-butyl)-4’-((6-iodo-4-oxo-2-propylquinazolin-3(4H)-yl)methyl)-[1,1’-biphenyl]-2-sulfonamide

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(3-((2'-(N-(tert-butyl)sulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-4-oxo-2-propyl-3,4-dihydroquinazolin-6-yl)oxazole-4-carboxylate

ethyl 2-(3-((2'-(N-(tert-butyl)sulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-4-oxo-2-propyl-3,4-dihydroquinazolin-6-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;83%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

2-iodo-5-carbethoxyoxazole

2-iodo-5-carbethoxyoxazole

Conditions
ConditionsYield
Stage #1: oxazol-5-yl-carboxylic acid ethyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran at 20℃; for 0.5h;
Stage #3: With iodine In tetrahydrofuran at -78 - 20℃; for 1.25h;		82%
Stage #1: oxazol-5-yl-carboxylic acid ethyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h;
Stage #2: With 1,2-Diiodoethane In tetrahydrofuran at -78℃; for 1.25h;		42%
3-bromo-5-chloropyridine
73583-39-8

3-bromo-5-chloropyridine

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(5-chloropyridin-3-yl)oxazole-4-carboxylate

ethyl 2-(5-chloropyridin-3-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;81%
oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

oxazole-5-carbaldehyde
118994-86-8

oxazole-5-carbaldehyde

Conditions
ConditionsYield
With n-butyllithium; diisobutylaluminium hydride; tert-butyl alcohol In tetrahydrofuran; hexane at 0℃;80%
With diisobutylaluminium hydride Inert atmosphere;0.73 g
iodomesitylene
4028-63-1

iodomesitylene

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

2-(2,4,6-trimethylphenylseleno)-1,3-oxazole-5-carboxylic acid ethyl ester

2-(2,4,6-trimethylphenylseleno)-1,3-oxazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With selenium; potassium phosphate; copper(l) chloride In N,N-dimethyl-formamide at 140℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere;77%
1-(1-methylethyl)piperazine
4318-42-7

1-(1-methylethyl)piperazine

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

(4-isopropylpiperazin-1-yl)(oxazol-5-yl)methanone

(4-isopropylpiperazin-1-yl)(oxazol-5-yl)methanone

Conditions
ConditionsYield
Stage #1: 1-(1-methylethyl)piperazine; oxazol-5-yl-carboxylic acid ethyl ester at 55℃; for 1h; Molecular sieve;
Stage #2: With lyophilysed lipase TL for 28.75h;		76%
Stage #1: 1-(1-methylethyl)piperazine; oxazol-5-yl-carboxylic acid ethyl ester at 55℃; for 1h;
Stage #2: With Lipase TL for 28.75h;		76%
ethyl 5-bromo-3-pyridinecarboxylate
20986-40-7

ethyl 5-bromo-3-pyridinecarboxylate

oxazol-5-yl-carboxylic acid ethyl ester
118994-89-1

oxazol-5-yl-carboxylic acid ethyl ester

ethyl 2-(5-(ethoxycarbonyl)pyridin-3-yl)oxazole-4-carboxylate

ethyl 2-(5-(ethoxycarbonyl)pyridin-3-yl)oxazole-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; Cu(1+)*C12H8N2*Br(1-)*C18H15P; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 110℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;75%

Ethyl oxazole-5-carboxylate Specification

The 5-Oxazolecarboxylicacid, ethyl ester, with its CAS registry number 118994-89-1, has the systematic name of ethyl 1,3-oxazole-5-carboxylate. With its molecular foumula of C6H7NO3, it has the formula weight of 141.12. Besides, its product categories are including Carboxylicester; Blocks; Oxazoles. For being a kind of irritant chemical, it may cause inflammation to the skin or other mucous membranes. 

The characteristics of 5-Oxazolecarboxylicacid, ethyl ester are as follows: (1)ACD/LogP: 0.28; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1; (4)ACD/LogD (pH 7.4): 1; (5)ACD/BCF (pH 5.5): 2; (6)ACD/BCF (pH 7.4): 2; (7)ACD/KOC (pH 5.5): 52; (8)ACD/KOC (pH 7.4): 52; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 52.33 Å2; (13)Index of Refraction: 1.464; (14)Molar Refractivity: 33.05 cm3; (15)Molar Volume: 119.851 cm3; (16)Polarizability: 13.102×10-24cm3; (17)Surface Tension: 39.275 dyne/cm; (18)Density: 1.177 g/cm3; (19)Flash Point: 75.947 °C; (20)Enthalpy of Vaporization: 43.818 kJ/mol; (21)Boiling Point: 201.966 °C at 760 mmHg; (22)Vapour Pressure: 0.3 mmHg at 25°C.

What's more, the following datas could be converted into the molecular structure:
(1)SMILES:O=C(OCC)c1ocnc1
(2)InChI:InChI=1/C6H7NO3/c1-2-9-6(8)5-3-7-4-10-5/h3-4H,2H2,1H3
(3)InChIKey:KRMORCCAHXFIHF-UHFFFAOYAO
(4)Std. InChI:InChI=1S/C6H7NO3/c1-2-9-6(8)5-3-7-4-10-5/h3-4H,2H2,1H3
(5)Std. InChIKey:KRMORCCAHXFIHF-UHFFFAOYSA-N

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