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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-Bromo-5-(trifluoromethyl)pyridine Manufacturer/High quality/Best price/In stock

Cas:50488-42-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Bromo-5-Trifluoromethylpyridine

Cas:50488-42-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

2-Bromo-5-(trifluoromethyl)pyridine CAS 50488-42-1 with competitive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/

2-Bromo-5-(trifluoromethyl)pyridine CAS 50488-42-1 with competitive price

Cas:50488-42-1

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2-bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Bromo-5-(trifluoromethyl)-pyridine

Cas:50488-42-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFUCHEM- 2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:1 Kilogram

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 50488-42-1 with fast shipping

Cas:50488-42-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Bromo-5-(trifluoromethyl)pyridine 50488-42-1

Cas:50488-42-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

2-Bromo-5-(trifluoromethyl)pyridine manufacturer with low price

Cas:50488-42-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 50488-42-1 ,2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se

2-Bromo-5-trifluoromethylpyridine

Cas:50488-42-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Bromo-5-trifluoromethylpyridine

Cas:50488-42-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Flu

2-Bromo-5-(trifluoromethyl)pyridineCAS NO.: 50488-42-1

Cas:50488-42-1

Min.Order:1 Gram

FOB Price: $9.0 / 10.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

2-Bromo-5-(trifluoromethyl)pyridine Chemical Properties Melting point 44-48 °C Boiling point 78 °C density 1.707±0.06 g/cm3(Predicted) Fp 78-81°C/30mm storage temp. Room temperature. solubility Soluble in me

2-Bromo-5-trifluoromethylpyridine

Cas:50488-42-1

Min.Order:200 Gram

FOB Price: $14.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:0

Negotiable

Type:Other

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:0

Negotiable

Type:Manufacturers

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/2-Bromo-5-trifluoromethylpyridine

Cas:50488-42-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)

Capability on chemical synthesis1. Beijing High-Tech Enterprises2. Strong R&D Team3. 8 years of experiences in R & D of high-tech Catalyst;4. 5000 production techniques, 69 items of national patents, and 360 kinds of products on sales;5. The producti

2-Bromo-5-trifluoromethylpyridine

Cas:50488-42-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-Bromo-5-(trifluoromethyl)pyridine

Cas:50488-42-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Synthetic route

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With trimethylsilyl bromide In various solvent(s) for 20h; Heating;76%
2-bromo-5-iodo-pyridine
73290-22-9

2-bromo-5-iodo-pyridine

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium fluoride; copper(l) iodide In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 25℃; for 6h;29%
2,5-dibromopyridine
624-28-2

2,5-dibromopyridine

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: nBuLi / hexane; diethyl ether / 0.75 h / -75 °C
1.2: 84 percent / I2 / hexane; tetrahydrofuran; diethyl ether / 0.75 h / -75 °C
2.1: 29 percent / KF; CuI / dimethylformamide; 1-methyl-pyrrolidin-2-one / 6 h / 25 °C
View Scheme
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester
124236-37-9

5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 at 80℃; under 3102.97 Torr; for 3h;100%
tert-butyl (2-chloroethoxy)dimethyl silane
89031-81-2

tert-butyl (2-chloroethoxy)dimethyl silane

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(2-(tert-butyldimethylsilyloxy)ethylthio)-5-(trifluoromethyl)pyridine
1558056-06-6

2-(2-(tert-butyldimethylsilyloxy)ethylthio)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Sodium thiosulfate pentahydrate; caesium carbonate In ethylene glycol; dimethyl sulfoxide at 120℃; Schlenk technique; Inert atmosphere; Green chemistry;98%
With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Sodium thiosulfate pentahydrate; caesium carbonate In ethylene glycol; dimethyl sulfoxide at 120℃; Inert atmosphere;98%
(8R,9aS)-8-hydroxyoctahydro-5H-pyrrolo[1,2-a][1,4]diazepin-5-one hydrochloride
1613630-17-3

(8R,9aS)-8-hydroxyoctahydro-5H-pyrrolo[1,2-a][1,4]diazepin-5-one hydrochloride

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

(8R,9aS)-8-hydroxy-2-[5-(trifluoromethyl)pyridin-2-yl]octahydro-5H-pyrrolo[1,2-a][1,4]diazepin-5-one
1613630-18-4

(8R,9aS)-8-hydroxy-2-[5-(trifluoromethyl)pyridin-2-yl]octahydro-5H-pyrrolo[1,2-a][1,4]diazepin-5-one

Conditions
ConditionsYield
With sodium carbonate In dimethyl sulfoxide at 100℃;98%
potassium (2,4-difluorophenyl)trifluoroborate

potassium (2,4-difluorophenyl)trifluoroborate

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
387827-64-7

2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 24h; Suzuki Coupling; Inert atmosphere; Sealed tube;98%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 24h;98%
S-Methylisothiourea sulfate
867-44-7

S-Methylisothiourea sulfate

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(methylthio)-5-(trifluoromethyl)pyridine
650592-47-5

2-(methylthio)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 80℃; for 1h;98%
para-thiocresol
106-45-6

para-thiocresol

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(p-tolylthio)-5-(trifluoromethyl)pyridine

2-(p-tolylthio)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Sealed tube; Inert atmosphere;98%
5-(5-bromo-1-methyl-1H-pyrazol-4-yl)-7-methyl-4-(pyrrolidin-1-yl)imidazo[5,1-f][1,2,4]triazine

5-(5-bromo-1-methyl-1H-pyrazol-4-yl)-7-methyl-4-(pyrrolidin-1-yl)imidazo[5,1-f][1,2,4]triazine

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

7-methyl-5-(1-methyl-5-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-4-yl)-4-(pyrrolidin-1-yl)imidazo[5,1-f][1,2,4]triazine

7-methyl-5-(1-methyl-5-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-4-yl)-4-(pyrrolidin-1-yl)imidazo[5,1-f][1,2,4]triazine

Conditions
ConditionsYield
Stage #1: 5-(5-bromo-1-methyl-1H-pyrazol-4-yl)-7-methyl-4-(pyrrolidin-1-yl)imidazo[5,1-f][1,2,4]triazine With TurboGrignard In tetrahydrofuran; 2-methyltetrahydrofuran at -10℃; for 1h; Inert atmosphere;
Stage #2: With zinc(II) chloride In tetrahydrofuran; 2-methyltetrahydrofuran at -10 - 20℃; for 1h; Inert atmosphere;
Stage #3: 2-bromo-5-(trifluoromethyl)pyridine With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In tetrahydrofuran; 2-methyltetrahydrofuran at 80℃; for 22h; Inert atmosphere;
97%
4-(carbazol-9-yl)phenylboronic acid
419536-33-7

4-(carbazol-9-yl)phenylboronic acid

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

9-(4-(5-(trifluoromethyl)pyridin-2-yl)-phenyl)-9H-carbazole
1617519-03-5

9-(4-(5-(trifluoromethyl)pyridin-2-yl)-phenyl)-9H-carbazole

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate In ethanol; water at 80℃;96%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; N,N-dimethyl-formamide at 120℃; for 48h; Suzuki Coupling; Schlenk technique;78%
3-chloro-5-(dihydroxyboryl)-1-(4-isopropoxyphenyl)-1H-indole-2-carboxylic acid ethyl ester
871829-81-1

3-chloro-5-(dihydroxyboryl)-1-(4-isopropoxyphenyl)-1H-indole-2-carboxylic acid ethyl ester

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

3-chloro-1-(4-isopropoxyphenyl)-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester
871829-82-2

3-chloro-1-(4-isopropoxyphenyl)-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene at 85℃; for 3h;95%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; toluene at 85℃; for 3h; Product distribution / selectivity;95%
2,4-difluorophenylboronic acid
144025-03-6

2,4-difluorophenylboronic acid

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
387827-64-7

2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water for 36h; Reflux; Inert atmosphere;95%
With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) In tetrahydrofuran; water at 40℃; for 4h; Inert atmosphere;95%
With palladium diacetate; potassium carbonate; triphenylphosphine In ethanol; water; toluene Inert atmosphere; Reflux;86%
2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

4-(diphenylamino)phenyl boronic acid
201802-67-7

4-(diphenylamino)phenyl boronic acid

N-[4-(5-trifluoromethylpyridin-2-yl)phenyl]-N,N-diphenylamine

N-[4-(5-trifluoromethylpyridin-2-yl)phenyl]-N,N-diphenylamine

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate In ethanol; water at 80℃; for 0.166667h; Suzuki Coupling;95%
With palladium diacetate; potassium carbonate In ethanol; water at 80℃; Suzuki Coupling;
With palladium diacetate; potassium carbonate In ethanol; water at 80℃; Suzuki Coupling;
2,4-difluorophenylboronic acid
144025-03-6

2,4-difluorophenylboronic acid

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(2,4-difluorophenyl)-4-(trifluoromethyl)pyridine

2-(2,4-difluorophenyl)-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran at 70℃; for 17h; Inert atmosphere; Schlenk technique;95%
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole-2-carboxylic acid ethyl ester
736990-02-6

5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole-2-carboxylic acid ethyl ester

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester
871829-38-8

5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene at 80℃; for 24h;94%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; toluene at 80℃; for 24h;94%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; toluene at 80℃; for 18h;77%
methyl 2-[(tert-butoxycarbonyl)amino]acrylate
55477-80-0

methyl 2-[(tert-butoxycarbonyl)amino]acrylate

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

C15H19F3N2O4

C15H19F3N2O4

Conditions
ConditionsYield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In water; dimethyl sulfoxide at 23℃; for 16h; Irradiation;94%
5-bromo-2-methoxypyridine-3-carbonitrile
941294-54-8

5-bromo-2-methoxypyridine-3-carbonitrile

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-methoxy-5-[5-(trifluoromethyl)-2-pyridyl]pyridine-3-carbonitrile

2-methoxy-5-[5-(trifluoromethyl)-2-pyridyl]pyridine-3-carbonitrile

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methoxypyridine-3-carbonitrile With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; bis(pinacol)diborane In 1,4-dioxane at 120℃; for 30h; Microwave irradiation;
Stage #2: 2-bromo-5-(trifluoromethyl)pyridine With sodium carbonate In 1,4-dioxane; water at 100℃; for 0.5h; Microwave irradiation;
94%
4-azetidin-1-yl-7-methyl-5-(1-methyl-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazine
1394034-58-2

4-azetidin-1-yl-7-methyl-5-(1-methyl-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazine

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazine
1394033-54-5

4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazine

Conditions
ConditionsYield
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In 1,4-dioxane; dichloromethane at 102℃; for 36h; Inert atmosphere;93%
With bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate In 1,4-dioxane at 102℃; for 36h; Inert atmosphere; Reflux;93%
thiophene boronic acid
6165-68-0

thiophene boronic acid

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(thiophen-2-yl)-5-(trifluoromethyl)pyridine

2-(thiophen-2-yl)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,2-dimethoxyethane; water at 80℃; for 14h;93%
3-bromo-1H-pyrazole
14521-80-3

3-bromo-1H-pyrazole

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(3-bromo-1H-pyrazol-1-yl)-5-(trifluoromethyl)pyridine

2-(3-bromo-1H-pyrazol-1-yl)-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 18h;92.6%
1-(4-cyclopentyloxyphenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indole-2-carbonitrile
902772-15-0

1-(4-cyclopentyloxyphenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indole-2-carbonitrile

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

1-(4-cyclopentyloxyphenyl)-5-(5-trifluoromethylpyridin-2-yl)-indole-2-carbonitrile
902772-16-1

1-(4-cyclopentyloxyphenyl)-5-(5-trifluoromethylpyridin-2-yl)-indole-2-carbonitrile

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene at 80℃; for 23h;92%
isopropylamine
75-31-0

isopropylamine

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

N-isopropyl-5-(trifluoromethyl)pyridin-2-amine
847240-94-2

N-isopropyl-5-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
at 100℃; for 8h; Sealed tube;92%
2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

(5-cyano-2-methoxyphenyl)boronic acid
612833-37-1

(5-cyano-2-methoxyphenyl)boronic acid

4-methoxy-3-[5-(trifluoromethyl)-2-pyridyl]benzonitrile

4-methoxy-3-[5-(trifluoromethyl)-2-pyridyl]benzonitrile

Conditions
ConditionsYield
With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium carbonate In water; N,N-dimethyl-formamide at 100℃; for 2h;92%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In water; N,N-dimethyl-formamide at 100℃; for 2h;92%
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate
375853-82-0, 286961-14-6

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

tert-butyl 5-(trifluoromethyl)-1,2,3,6-tetrahydro-[2,4-bipyridine]-1-carboxylate

tert-butyl 5-(trifluoromethyl)-1,2,3,6-tetrahydro-[2,4-bipyridine]-1-carboxylate

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In water; toluene at 85℃; for 3h; Temperature; Solvent; Sealed tube; Inert atmosphere;91.2%
4,4,5,5-tetramethyl-2-(2,2'',5,5''-tetramethyl-[3,2':3’,3''-terthiophen]-5'-yl)-1,3,2-dioxaborolane
1320351-63-0

4,4,5,5-tetramethyl-2-(2,2'',5,5''-tetramethyl-[3,2':3’,3''-terthiophen]-5'-yl)-1,3,2-dioxaborolane

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-(2,2'',5,5''-tetramethyl-[3,2':3',3''-terthiophen]-5'-yl)-5-(trifluoromethyl)-pyridine
1320351-72-1

2-(2,2'',5,5''-tetramethyl-[3,2':3',3''-terthiophen]-5'-yl)-5-(trifluoromethyl)-pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In tetrahydrofuran; water Suzuki coupling; Reflux;91%
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In tetrahydrofuran; water Inert atmosphere;
p-hydroxymethylphenylboronic acid
59016-93-2

p-hydroxymethylphenylboronic acid

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

C19H12F3N3

C19H12F3N3

Conditions
ConditionsYield
With 5%-palladium/activated carbon; ammonium bicarbonate In water at 100℃; for 24h; Schlenk technique; Inert atmosphere; Green chemistry;91%
1-dimesitylboryl-2-ethynylbenzene
1058722-73-8

1-dimesitylboryl-2-ethynylbenzene

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

C32H29BF3N

C32H29BF3N

Conditions
ConditionsYield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine In tetrahydrofuran at 90℃; Schlenk technique; Inert atmosphere;91%
2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

5-trifluoromethyl-pyridin-2-ylhydrazine
89570-85-4

5-trifluoromethyl-pyridin-2-ylhydrazine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 20 - 90℃;90%
Stage #1: 2-bromo-5-(trifluoromethyl)pyridine With t-butoxycarbonylhydrazine; t-BuBrettPhos; [tBuBrettPhosPd(allyl)]OTf; sodium t-butanolate In water at 45℃; for 16h; Inert atmosphere;
Stage #2: With sulfuric acid In ethanol; water at 90 - 95℃; Inert atmosphere; Sealed tube;
S-tert-butylsulfinimide
146374-27-8

S-tert-butylsulfinimide

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

2-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)propane-2-sulfinamide
1338209-78-1

2-methyl-N-(5-(trifluoromethyl)pyridin-2-yl)propane-2-sulfinamide

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 15h; Inert atmosphere;89%
(7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate
1204603-42-8

(7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

tert-butyl (7R,8aS)-7-{[5-(trifluoromethyl)pyridin-2-yl]oxy}hexahydro-pyrrolo[1,2-a]pyrazine-2(1H)-carboxylate
1429200-40-7

tert-butyl (7R,8aS)-7-{[5-(trifluoromethyl)pyridin-2-yl]oxy}hexahydro-pyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h;88%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

1-(5-(trifluoromethyl)pyridin-2-yl)-2,3,4,6,7,8-hexahydro-pyrimido-[1,2-a]pyrimidine

1-(5-(trifluoromethyl)pyridin-2-yl)-2,3,4,6,7,8-hexahydro-pyrimido-[1,2-a]pyrimidine

Conditions
ConditionsYield
Stage #1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 2-bromo-5-(trifluoromethyl)pyridine With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 20℃; for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: With potassium tert-butylate In toluene at 90℃; for 5h; Schlenk technique; Inert atmosphere;
88%
tert-butyl (3R)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
1227473-84-8

tert-butyl (3R)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

2-bromo-5-(trifluoromethyl)pyridine
50488-42-1

2-bromo-5-(trifluoromethyl)pyridine

tert-butyl (3R)-3-(3-[5-(trifluoromethyl)pyridin-2-yl]phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
1227473-85-9

tert-butyl (3R)-3-(3-[5-(trifluoromethyl)pyridin-2-yl]phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Conditions
ConditionsYield
With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride In water; acetonitrile at 85℃; Suzuki Coupling;87%

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