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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cas:5807-14-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearan

1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cas:5807-14-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:1

Negotiable

Type:Other

inquiry

Sinoway Industrial Co., Ltd.

Purity: 99.0% up; Stable supply with over 100kg annually; Appearance:colorless transpartent liquid Storage:room temprature Package:25kg/drum Application:Organic Building Block Port:Beijing/Shanghai/Shenzhen/Hangzhou

1,5,7-Triazabicyclo[4.4.0]dec-5-ene, TBD, organic catalyst

Cas:5807-14-7

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cas:5807-14-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 5807-14-7 with best quality

Cas:5807-14-7

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we a

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:1 Kilogram

FOB Price: $777.0 / 888.0

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine CAS5807-14-7

Cas:5807-14-7

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINECAS NO.:5807-14-7

Cas:5807-14-7

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine 5807-14-7

Cas:5807-14-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE Synonyms: LABOTEST-BB LT00847641;1,5,7-TRIAZABICYCLO[4.4.0]DEC-5-ENE;1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE;1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE, POLYMER

1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE

Cas:5807-14-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1,5,7-Triazabicyclo[4.4.0]dec-5-ene CAS:5807-14-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

1,5,7-Triazabicyclo[4.4.0]dec-5-ene CAS:5807-14-7

Cas:5807-14-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE

Cas:5807-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE

Cas:5807-14-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and als

1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cas:5807-14-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cas:5807-14-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermed

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE

Cas:5807-14-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 1,5,7-Triazabicyclo[4.4.0]Dec-5-Ene CAS No.:5807-14-7 Molecule Formula:C7H13N3 Molecule Weight:139.20 Purity: 99.0% Package: 25kg/drum Description:White or off-white crystalline powder Manufacture Standards:Enterprise Standard

Best Quality 1,5,7-Triazabicyclo[4.4.0]Dec-5-Ene

Cas:5807-14-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cas:5807-14-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

In Bulk Supply1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE

Cas:5807-14-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Appearance:white to light yellow solid Application:Pharmaceutical Intermediate

1,3,4,6,7,8-HEXAHYDRO-2H-PYRIMIDO[1,2-A]PYRIMIDINE

Cas:5807-14-7

Min.Order:200 Gram

Negotiable

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cas:5807-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine

Cas:5807-14-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

1,5,7-Triazabicyclo[4.4.0]dec-5-ene Cas no.5807-14-7 98%

Cas:5807-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

guanidine hydrochloride
50-01-1

guanidine hydrochloride

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
Stage #1: bis(3-aminopropyl)amine; guanidine hydrochloride With hydrogenchloride at 155℃;
Stage #2: With sodium methylate In methanol
93%
With anion exchange resin (D201) In water; 1,3,5-trimethyl-benzene at 120℃; for 9h; Temperature; Autoclave; Inert atmosphere;55%
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

isooctyltriethoxysilane

isooctyltriethoxysilane

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
Stage #1: bis(3-aminopropyl)amine; carbonic acid dimethyl ester at 60 - 250℃; for 4h;
Stage #2: isooctyltriethoxysilane at 250℃; for 9h; Temperature; Reagent/catalyst;
87%
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

di-p-tolylcarbodiimide
726-42-1

di-p-tolylcarbodiimide

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
With [ς:η1:η5-(OCH2)(Me2NCH2)C2B9H9]Ti-(NMe2) In toluene at 115℃; for 240h;76%
With 2-Butoxyethanol at 23 - 170℃; for 15h;
<3-chloro-propyl>-<1,4,5,6-tetrahydro-pyrimidin-2-yl>-amine hydrochloride

<3-chloro-propyl>-<1,4,5,6-tetrahydro-pyrimidin-2-yl>-amine hydrochloride

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
With potassium hydroxide
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine tetraphenylborate
229311-99-3

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine tetraphenylborate

A

C24H21B

C24H21B

B

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
In acetonitrile Quantum yield; Kinetics; Mechanism; Time; Concentration; UV-irradiation at 254 nm; Inert atmosphere;
1-(3-aminopropyl)tetrahydro-2(1H)-pyrimidinone
13173-07-4

1-(3-aminopropyl)tetrahydro-2(1H)-pyrimidinone

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
In Triethylene glycol dimethyl ether at 100 - 230℃; Product distribution / selectivity; Inert atmosphere;
7-acetyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene

7-acetyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene

N-butylamine
109-73-9

N-butylamine

A

N-butylacetamide
1119-49-9

N-butylacetamide

B

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
In (2)H8-toluene at 24.84℃; Kinetics; Inert atmosphere;
7-acetyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene

7-acetyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene

benzyl alcohol
100-51-6

benzyl alcohol

A

Benzyl acetate
140-11-4

Benzyl acetate

B

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
In (2)H8-toluene at 24.84℃; Kinetics; Inert atmosphere;
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

N-Cyanoguanidine
127099-85-8, 780722-26-1

N-Cyanoguanidine

A

2,4,6-triamino-s-triazine
108-78-1

2,4,6-triamino-s-triazine

B

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
In 2-Butoxyethanol at 60 - 170℃; for 2h; Inert atmosphere;A 47 %Spectr.
B 34 %Spectr.
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

N-Cyanoguanidine
127099-85-8, 780722-26-1

N-Cyanoguanidine

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
With carbon dioxide In 2-Butoxyethanol at 60 - 130℃; for 6h;57 %Spectr.
With toluene-4-sulfonic acid at 220 - 230℃; for 6h; Inert atmosphere;
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

CYANAMID
420-04-2

CYANAMID

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
Stage #1: bis(3-aminopropyl)amine; CYANAMID With hydrogenchloride at 155℃;
Stage #2: With sodium methylate In methanol
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

diisopropyl-carbodiimide
693-13-0

diisopropyl-carbodiimide

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
With 2-Butoxyethanol; isopropylamine at 60 - 170℃; for 12h;
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

dicyclohexyl-carbodiimide
538-75-0

dicyclohexyl-carbodiimide

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
With 2-Butoxyethanol at 60 - 170℃; for 18h; Reagent/catalyst; Temperature;
C15H10O4*C7H13N3
1333123-53-7

C15H10O4*C7H13N3

A

2-methyl-9H-xanthen-9-one
6280-45-1

2-methyl-9H-xanthen-9-one

B

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
In methanol UV-irradiation;
C7H13N3*C16H14O3
1333123-47-9

C7H13N3*C16H14O3

A

3-ethylbenzophenone
66067-43-4

3-ethylbenzophenone

B

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
In methanol UV-irradiation;
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

A

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

B

1,3,4,6,7,8-hexahydro-1-methyl-2H-pyrimido[1,2-a]pyrimidine

1,3,4,6,7,8-hexahydro-1-methyl-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol / 16 h / 180 °C / 3750.38 - 45754.6 Torr / Autoclave
2: silica-doped aluminum oxide / methanol / 253 °C / 750.08 Torr / Inert atmosphere
View Scheme
bis(3-aminopropyl)amine
56-18-8

bis(3-aminopropyl)amine

carbon dioxide
124-38-9

carbon dioxide

A

1-(3-aminopropyl)tetrahydro-2(1H)-pyrimidinone
13173-07-4

1-(3-aminopropyl)tetrahydro-2(1H)-pyrimidinone

B

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

C

1-methyltetrahydropyrimidin-2(1H)-one
10166-54-8

1-methyltetrahydropyrimidin-2(1H)-one

D

1-ethyltetrahydropyrimidin-2(1 H)-one
66639-75-6

1-ethyltetrahydropyrimidin-2(1 H)-one

Conditions
ConditionsYield
In methanol at 180℃; under 3750.38 - 45754.6 Torr; for 16h; Pressure; Solvent; Autoclave;
1-(3-aminopropyl)tetrahydro-2(1H)-pyrimidinone
13173-07-4

1-(3-aminopropyl)tetrahydro-2(1H)-pyrimidinone

A

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

B

1,3,4,6,7,8-hexahydro-1-methyl-2H-pyrimido[1,2-a]pyrimidine

1,3,4,6,7,8-hexahydro-1-methyl-2H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
With silica-doped aluminum oxide In methanol at 253℃; under 750.075 Torr; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;
2-(benzyloxy)propane-1,3-diyl bis(4-methylbenzenesulfonate)
19945-19-8

2-(benzyloxy)propane-1,3-diyl bis(4-methylbenzenesulfonate)

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

2-(benzyloxy)octahydro-3a,6a,9a-triazaphenalene
160154-14-3

2-(benzyloxy)octahydro-3a,6a,9a-triazaphenalene

Conditions
ConditionsYield
With potassium hydroxide; sodium tetrahydroborate; potassium bromide In toluene for 42.5h; Ambient temperature;100%
Stage #1: 2-(benzyloxy)propane-1,3-diyl bis(4-methylbenzenesulfonate); 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine With potassium hydroxide In 1,4-dioxane for 48h; Heating;
Stage #2: With sodium tetrahydroborate In 1,4-dioxane at 20℃; for 48h;
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

diisopropyl-carbodiimide
693-13-0

diisopropyl-carbodiimide

(Z)-N,N′-diisopropyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine-1-carboximidamide

(Z)-N,N′-diisopropyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine-1-carboximidamide

Conditions
ConditionsYield
at 20℃; for 48h; Inert atmosphere;100%
With acid43%
carbon dioxide
124-38-9

carbon dioxide

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

[TBDH][HCO3]

[TBDH][HCO3]

Conditions
ConditionsYield
With water In tetrahydrofuran at 20℃; under 760.051 Torr; for 0.5h;100%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

tetrafluoroborate guanidinium salt

tetrafluoroborate guanidinium salt

Conditions
ConditionsYield
With tetrafluoroboric acid In methanol; water at 0℃; for 0.5h;100%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

1,3-Diamino-2-hydroxypropane
616-29-5

1,3-Diamino-2-hydroxypropane

Diethyl carbonate
105-58-8

Diethyl carbonate

tetrahydro-5-hydroxy-2(1H)-pyrimidinone
1852-18-2

tetrahydro-5-hydroxy-2(1H)-pyrimidinone

Conditions
ConditionsYield
100%
formic acid
64-18-6

formic acid

carbon dioxide
124-38-9

carbon dioxide

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

CH2O2*C7H13N3
1356453-15-0

CH2O2*C7H13N3

Conditions
ConditionsYield
In diethyl ether at 30℃; under 750.075 Torr; for 1h; Inert atmosphere;100%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

p-Tolylisocyanate
622-58-2

p-Tolylisocyanate

N-(p-tolyl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine-1-carboxamide

N-(p-tolyl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine-1-carboxamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;100%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

1-isothiocyanato-4-methylbenzene
622-59-3

1-isothiocyanato-4-methylbenzene

(Z)-N-p-tolyl-2,3,4,6,7,8-hexahydro-1H-pyrimido-[1,2-a]pyrimidin-9-ium-1-carbimidothioate

(Z)-N-p-tolyl-2,3,4,6,7,8-hexahydro-1H-pyrimido-[1,2-a]pyrimidin-9-ium-1-carbimidothioate

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;100%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

p-trifluoromethyl-phenylisocyanate
1548-13-6

p-trifluoromethyl-phenylisocyanate

benzene
71-43-2

benzene

N-[4-(trifluoromethyl)phenyl]-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine-1-carboxamide

N-[4-(trifluoromethyl)phenyl]-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine-1-carboxamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;100%
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

C7H14N3(1+)*C2H2F3O(1-)

C7H14N3(1+)*C2H2F3O(1-)

Conditions
ConditionsYield
at 50℃; for 24h; Cooling with ice; Inert atmosphere;100%
1,2-W2(i-Bu)2(NMe2)4

1,2-W2(i-Bu)2(NMe2)4

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

W2(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)4
463931-34-2

W2(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)4

Conditions
ConditionsYield
In benzene (Ar); stirred for 3 d; evapd., dried, dissolved in C6H6, pptd. with hexane, filtered, washed (hexane), dried;99%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine hydroiodide

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine hydroiodide

Conditions
ConditionsYield
With hydrogen iodide In water at 0 - 20℃; for 2h;99%
Multi-step reaction with 2 steps
1: ammonium chloride / methanol / 4 h / 20 °C / Inert atmosphere
2: sodium iodide / dichloromethane / 24 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: ammonium chloride / methanol / 1 h / 20 °C
2: sodium iodide / dichloromethane / 16 h / 20 °C
View Scheme
W2Cl2(NMe2)4

W2Cl2(NMe2)4

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

W2(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)4Cl2
280107-73-5, 874340-22-4

W2(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)4Cl2

Conditions
ConditionsYield
In melt byproducts: HNMe2; (N2 or Ar); W2Cl2(NMe2)4 placed together with ligand, finely ground, heated under Ar at 150°C for 15 h; evacuated on cooling, powdered finely, heated at 150°C under 1E-4Torr, recrystd. (CH2Cl2); elem. anal.;98%
carbon dioxide
124-38-9

carbon dioxide

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidin-9-ium-9-carboxylate

2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidin-9-ium-9-carboxylate

Conditions
ConditionsYield
In tetrahydrofuran under 760.051 Torr;98%
In tetrahydrofuran at 20℃; under 760.051 Torr; for 0.0833333h; Inert atmosphere;98%
In tetrahydrofuran at 20℃; under 750.075 Torr; for 1h; Inert atmosphere; Schlenk technique;
(C5Me5)2Ce(η3-CH2CHCH2)(THF)
863223-65-8

(C5Me5)2Ce(η3-CH2CHCH2)(THF)

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

(C5Me5)2Ce(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)

(C5Me5)2Ce(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)

Conditions
ConditionsYield
In toluene byproducts: C3H6, C4H8O; (Ar or N2); soln. of pyrimidine in toluene was added to soln. of cerium complex in toluene, stirred for 12 h; evapd. in vac., elem. anal.;97%
(C5Me5)2Sm(η3-CH2CHCH2)(THF)
1085985-44-9

(C5Me5)2Sm(η3-CH2CHCH2)(THF)

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

(C5Me5)2Sm(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)

(C5Me5)2Sm(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)

Conditions
ConditionsYield
In toluene byproducts: C3H6, C4H8O; (Ar or N2); soln. of pyrimidine in toluene was added to soln. of samarium complex in toluene, stirred for 12 h; evapd. in vac., elem. anal.;97%
dimethylbis(η5-pentamethylcyclopentadienyl)uranium
67605-92-9

dimethylbis(η5-pentamethylcyclopentadienyl)uranium

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

[UMe(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidinato)(pentamethylcyclopentadienyl)2]
1202368-33-9

[UMe(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidinato)(pentamethylcyclopentadienyl)2]

Conditions
ConditionsYield
In toluene byproducts: CH4; (N2); ligand was added with stirring to soln. of U complex in toluene; stirred for 12 h; evapd. (vac.); elem. anal.;97%
[1-(N-pivaloylamino)ethyl]triphenylphosphonium tetrafluoroborate

[1-(N-pivaloylamino)ethyl]triphenylphosphonium tetrafluoroborate

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

5-[1-(N-pivaloylamino)ethyl]-1,7-diaza-5-azoniabicyclo[4.4.0.]dec-5-ene tetrafluoroborate

5-[1-(N-pivaloylamino)ethyl]-1,7-diaza-5-azoniabicyclo[4.4.0.]dec-5-ene tetrafluoroborate

Conditions
ConditionsYield
In acetonitrile at 20℃; for 0.166667h;97%
[1-(N-benzyloxycarbonylamino)ethyl]triphenylphosphonium tetrafluoroborate

[1-(N-benzyloxycarbonylamino)ethyl]triphenylphosphonium tetrafluoroborate

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

5-[1-(N-benzyloxycarbonylamino)ethyl]-1,7-diaza-5-azoniabicyclo[4.4.0.]dec-5-ene tetrafluoroborate

5-[1-(N-benzyloxycarbonylamino)ethyl]-1,7-diaza-5-azoniabicyclo[4.4.0.]dec-5-ene tetrafluoroborate

Conditions
ConditionsYield
In acetonitrile at 20℃; for 0.166667h;97%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

acetic acid
64-19-7

acetic acid

1,5,7-triazabicyclo[4.4.0]dec-5-enium acetate

1,5,7-triazabicyclo[4.4.0]dec-5-enium acetate

Conditions
ConditionsYield
In ethanol at 0 - 20℃; for 1h;97%
In hexane at 0 - 20℃; for 24h; Inert atmosphere;
(C5Me5)2Y(η3-CH2CHCH2)(THF)
378753-31-2

(C5Me5)2Y(η3-CH2CHCH2)(THF)

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

(C5Me5)2Y(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)

(C5Me5)2Y(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine)

Conditions
ConditionsYield
In toluene byproducts: C3H6, C4H8O; (Ar or N2); soln. of pyrimidine in toluene was added to soln. of samarium complex in toluene, stirred for 12 h; evapd. in vac., elem. anal.;96%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

trimethylamine-gallane adduct
19528-13-3

trimethylamine-gallane adduct

(H2Ga(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine(1-))2

(H2Ga(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine(1-))2

Conditions
ConditionsYield
[(κ3-C6H3-1,3-[OPtBu2]2)Ir(H)2] In diethyl ether; toluene standard Schlenk techniques under an inert gas; Ga-compd. in Et2O cooledto 0°C, added to pyrimidine-compd. in toluene at -95°C wi th cannula, stirred for 1.5 h, solid Ir-compd. added at -52°C, stirred for 6 h, warmed to -18°C; kept at -18°C for two weeks, elem. anal.;96%
2,5-dibromopyridine
624-28-2

2,5-dibromopyridine

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

1-(5-bromopyridin-2-yl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine
1537175-34-0

1-(5-bromopyridin-2-yl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
In neat (no solvent) at 90℃; for 3h; Sealed tube; Green chemistry;96%
at 90℃; for 3h; Sealed tube;96%
2-bromo-5-nitropyridine
4487-59-6

2-bromo-5-nitropyridine

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

1-(5-nitropyridin-2-yl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine

1-(5-nitropyridin-2-yl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine

Conditions
ConditionsYield
Stage #1: 2-bromo-5-nitropyridine With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 60℃; Inert atmosphere;
Stage #2: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine With potassium tert-butylate In toluene at 120℃; for 3h; Inert atmosphere;
96%
carbon disulfide
75-15-0

carbon disulfide

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidin-9-ium 2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine-1-carbodithioate

2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidin-9-ium 2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine-1-carbodithioate

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;96%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

C27H30N2O5

C27H30N2O5

C27H30N2O5*2C7H13N3

C27H30N2O5*2C7H13N3

Conditions
ConditionsYield
In methanol at 20℃; for 12h;95.3%
Mo2Cl2(NMe2)4

Mo2Cl2(NMe2)4

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Mo2(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidinato)4Cl2
603952-68-7, 645402-76-2

Mo2(1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidinato)4Cl2

Conditions
ConditionsYield
In melt byproducts: HNMe2; (N2 or Ar); Mo2Cl2(NMe2)4 placed together with ligand, finely ground, heated under Ar at 150°C for 12 h; evacuated on cooling, powdered finely, heated at 150°C under 1E-4Torr, recrystd. (CH2Cl2); elem. anal.;95%
3-imidazolyl-3-(4-methoxyphenyl)propionic acid

3-imidazolyl-3-(4-methoxyphenyl)propionic acid

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

C13H14N2O3*C7H13N3

C13H14N2O3*C7H13N3

Conditions
ConditionsYield
In methanol at 60℃; for 0.5h; Inert atmosphere;95%
In methanol at 60℃; for 0.5h; Inert atmosphere;95%
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

C25H26N2O5

C25H26N2O5

C25H26N2O5*2C7H13N3

C25H26N2O5*2C7H13N3

Conditions
ConditionsYield
In methanol at 30℃; for 1h;94.4%
1-chloro-2,3,4,5,6-pentafluorobenzene
344-07-0

1-chloro-2,3,4,5,6-pentafluorobenzene

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
5807-14-7

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

12-chloro-11,13,14-trifluoro-1,5,9-triaza-tricyclo[7.6.1.010,15]hexadeca-10,12,14-trien-16-one

12-chloro-11,13,14-trifluoro-1,5,9-triaza-tricyclo[7.6.1.010,15]hexadeca-10,12,14-trien-16-one

Conditions
ConditionsYield
With water In acetonitrile for 0.5h; Heating;94%
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