CAS No.58-08-2,Caffeine Suppliers,MSDS download

: 74-83-9
methyl bromide

: 69-89-6
xanthin

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With solution aqueuse d'hydroxide de sodium; tetrabutylammomium bromide In dichloromethane 1)room temp. 12h 2)reflux 3h;	100%

: 2,6-dimethoxy-7,9-dimethylpurinium iodide

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
In xylene at 140℃; for 0.75h; Rearrangement;	100%

: 3485-82-3
theophylline sodium salt

: 616-38-6
carbonic acid dimethyl ester

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; ethylene glycol at 135℃; for 4h; Autoclave; Green chemistry;	98.4%
With PEG 400 In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 12h; Solvent; Concentration; Temperature; Reagent/catalyst;	94.9%
With NaY (Y-type sodium zeolite catalyst); turkey red oil In water for 5h; Reflux;

: 74-83-9
methyl bromide

: 58-55-9
theophylline

A: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

B: 7280-81-1
3-benzyladenine

Conditions

Conditions	Yield
With solution aqueuse d'hydroxide de sodium; tetrabutylammomium bromide In dichloromethane 1)20 deg C, 12h 2)40 deg C, 3h;	A 98% B n/a

...Expand

: 107-31-3
Methyl formate

: 57533-87-6
1,3-Dimethylxanthine potassium salt

A: 58-55-9
theophylline

B: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
In methanol	A 97.5% B n/a

...Expand

: 67-56-1
methanol

: 57533-87-6
1,3-Dimethylxanthine potassium salt

A: 107-31-3
Methyl formate

B: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With carbon monoxide at 140℃; under 37503 Torr; for 20h;	A n/a B 97%

...Expand

: 58-55-9
theophylline

: 74-88-4
methyl iodide

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide for 0.75h;	95%
With sodium hydride In dimethyl sulfoxide at 20℃; for 24h; Reagent/catalyst;	90%

: 74-83-9
methyl bromide

: 83-67-0
theobromine /

A: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

B: 7280-81-1
3-benzyladenine

Conditions

Conditions	Yield
With solution aqueuse d'hydroxide de sodium; tetrabutylammomium bromide In dichloromethane 1)20 deg C, 12h 2)40 deg C, 3h;	A 94% B n/a

...Expand

: 1076-22-8
3-methylxanthine

: 77-78-1
dimethyl sulfate

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With tetramethyl ammoniumhydroxide; potassium carbonate In methanol; water at 65 - 70℃;	92.5%

: 83-67-0
theobromine /

: 77-78-1
dimethyl sulfate

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
potassium fluoride on basic alumina In acetonitrile for 24h; Ambient temperature;	92%
With sodium hydroxide

: 58-55-9
theophylline

: 616-38-6
carbonic acid dimethyl ester

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With cetyltrimethylammonium bromide; N-ethyl-N,N-diisopropylamine In toluene at 140℃; for 9h; Solvent; Concentration; Reagent/catalyst; Temperature;	90.7%
With 18-crown-6 ether In N,N-dimethyl-formamide at 90℃; for 12h;	67%
With DABCO-NaY (1:1 DABCO Y-type sodium zeolite catalyst); turkey red oil In water for 5h; Reagent/catalyst; Reflux;

: 58-55-9
theophylline

: 74-88-4
methyl iodide

A: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

B: 7280-81-1
3-benzyladenine

Conditions

Conditions	Yield
With solution aqueuse d'hydroxide de sodium; tetrabutylammomium bromide In dichloromethane 1)20 deg C, 12h 2)40 deg C, 3h;	A 90% B n/a

...Expand

: 58-55-9
theophylline

: 77-78-1
dimethyl sulfate

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
potassium fluoride on basic alumina In acetonitrile for 24h; Ambient temperature;	88%
With sodium hydroxide
With sodium hydroxide
With potassium hydroxide; Aliquat 336 1.) 20 deg C, 2 h, 2.) 1 h; Yield given. Multistep reaction;

: 58-55-9
theophylline

: 10504-60-6
diphenylmethylsulfonium tetrafluoroborate

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With potassium hydroxide In water; N,N-dimethyl-formamide at 20℃; for 3h;	88%

: 353-39-9
Trimethylsulfonium Fluoride

: 58-55-9
Theophylline

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 1h;	86%

: 69-89-6
xanthin

: 6257-10-9
N,N'-dicyclohexyl-O-methyl isourea

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 48h;	85%

: 58-55-9
theophylline

: 64-19-7
acetic acid

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With copper(I) thiophene-2-carboxylate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(5-methyl-2-(4-fluorophenyl)pyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; bathophenanthroline; iodomesitylene diacetate In 1,4-dioxane at 20℃; for 1h; Inert atmosphere; Irradiation; regioselective reaction;	82%

: 107605-83-4
4--1-methyl-5-methylaminocarbonylimidazole

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With sodium hydride In ethanol for 1.5h; Heating;	81%

: 83-67-0
theobromine /

: 616-38-6
carbonic acid dimethyl ester

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With 18-crown-6 ether In N,N-dimethyl-formamide at 90℃; for 12h;	78%

: 113613-79-9
1-methyl-9-aminoxanthine potassium salt

: 74-88-4
methyl iodide

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 3h;	76%

: 616-38-6
carbonic acid dimethyl ester

: 69-89-6
xanthin

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With 18-crown-6 ether In N,N-dimethyl-formamide at 90℃; for 12h;	74%

: 10381-82-5
8-bromocaffeine

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With copper In N,N-dimethyl-formamide for 2h; Heating;	72%

: 113613-76-6
1-methyl-9-aminoxanthine

: 74-88-4
methyl iodide

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 1h;	71%

: 107605-87-8
4-(N-trichloroacetyl-N-methylamino)-1-methyl-5-methylaminocarbonylimidazole

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With sodium hydride In ethanol for 2h; Heating;	66%

: 519-37-9
7-(2-hydroxyethyl)theophylline

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With cerium(III) chloride; 9,10-diphenylanthracene; 1,2-bis(2,4,6-triisopropylphenyl)disulfane; tetrabutyl-ammonium chloride In acetonitrile for 168h; Irradiation; Inert atmosphere;	63%

: 77-78-1
dimethyl sulfate

: 69-89-6
xanthin

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
potassium fluoride on basic alumina In acetonitrile for 24h; Ambient temperature;	61%
With alkaline solution
With sodium hydroxide

: 83-67-0
theobromine /

: 74-88-4
methyl iodide

A: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

B: 7280-81-1
3-benzyladenine

Conditions

Conditions	Yield
With solution aqueuse d'hydroxide de sodium; tetrabutylammomium bromide In dichloromethane 1)20 deg C, 12h 2)40 deg C, 3h;	A 56% B n/a

...Expand

: 18623-34-2
1,3,7,9-tetramethylxanthinium methyl sulfate

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
at 260℃; for 15h;	25%

: 58-55-9
theophylline

: 80-48-8
methyl p-toluene sulfonate

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
With sodium hydroxide

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 4921-49-7
8-chlorocaffeine

Conditions

Conditions	Yield
With chlorine In chloroform	100%
With chlorine In chloroform at 50℃; for 2h;	100%
With trichloroisocyanuric acid; brilliant green carbocation In acetonitrile at 20℃; for 2h; Irradiation; regioselective reaction;	78%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 10381-82-5
8-bromocaffeine

Conditions

Conditions	Yield
With N-Bromosuccinimide In dichloromethane; water for 120h;	100%
With N-Bromosuccinimide In dichloromethane; water for 120h;	99%
With N-Bromosuccinimide In dichloromethane; water for 120h;	99%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 8-deuterio-1,3,7-trimethylxanthine

Conditions

Conditions	Yield
With [(N,N’-bis(1R,2R,3R,5S)-(−)-isopinocampheyl-1,2-ethanediimine-radical)NiI(μ2-H)]2; deuterium In tetrahydrofuran at -196 - 45℃; under 760.051 Torr; for 24h; Sealed tube;	100%
With deuteromethanol; silver carbonate; johnphos In dichloromethane at 50 - 80℃;	98%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; deuterium In tetrahydrofuran at 55℃; under 750.075 Torr; for 22h; Inert atmosphere;	92%
With palladium 10% on activated carbon; hydrogen; water-d2 at 90℃; for 1.5h;	86.9%
With water-d2 at 150℃; for 0.25h; Microwave irradiation;

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 106-43-4
para-chlorotoluene

: 1,3,7-trimethyl-8-(4-methylphenyl)-1H-purine-3,7-dihydro-2,6-dione

Conditions

Conditions	Yield
With palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate In toluene at 20 - 130℃; for 24h; Inert atmosphere;	99%
With potassium phosphate; palladium diacetate In 1-methyl-pyrrolidin-2-one at 125℃; for 24h;	86%

: 104-92-7
1-bromo-4-methoxy-benzene

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 439927-43-2
1,3,7-trimethyl-8-(p-methoxyphenyl)-xanthine

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 20 - 120℃; for 7.16667h; Inert atmosphere;	99%
With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide at 20 - 140℃; for 36.1667h; Inert atmosphere; regioselective reaction;	98%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 501-65-5
diphenyl acetylene

: 99765-12-5
(E)-8-(1,2-Diphenylethenyl)-3,7-dihydro-1,3,7-trimethyl-1H-purin-2,6-dion

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; cesium acetate; 1,2-bis-(diphenylphosphino)ethane In toluene at 120℃; for 24h; Sealed vial; optical yield given as %de; stereoselective reaction;	99%
With bis(dibenzylideneacetone)-palladium(0); tricyclohexylphosphine; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 14h; Inert atmosphere; Glovebox; stereoselective reaction;	69%

: 401485-19-6
tert-butyl N-(thiophen-2-ylmethyl)carbamate

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 1403938-43-1
tert-butyl N-((5-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl) thiophen-2-yl)methyl)carbamate

Conditions

Conditions	Yield
With pyridine; palladium diacetate; copper(II) acetate monohydrate; copper(l) chloride In 1,4-dioxane at 120℃; for 20h; Schlenk technique; Inert atmosphere;	99%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 612-55-5
2-iodonaphthalene

: 1257390-78-5
1,3,7-trimethyl-8-(naphthalen-2-yl)-xanthine

Conditions

Conditions	Yield
With (1-(2-(tert-butylamino)ethyl)-3-mesityl-2,3-dihydro-1H-imidazol-2-yl)copper(I) iodide; lithium tert-butoxide In N,N-dimethyl-formamide at 140℃; for 8h; Glovebox;	99%

: 288-13-1
NH-pyrazole

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 1,3,7-trimethyl-4,5,8-tri(1H-pyrazol-1-yl)-3,4,5,7-tetrahydro-1H-purine-2,6-dione

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate In acetonitrile at 45℃; for 10h; Temperature; Inert atmosphere; Electrochemical reaction; Green chemistry; diastereoselective reaction;	99%

: 2075-45-8
4-bromo-1H-pyrazole

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 4,5,8-tris(4-bromo-1H-pyrazol-1-yl)-1,3,7-trimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate In acetonitrile at 45℃; for 10h; Inert atmosphere; Electrochemical reaction; Green chemistry; diastereoselective reaction;	99%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 13808-64-5
4-bromo-3-methyl-1H-pyrazole

: 4,5,8-tris(4-bromo-3-methyl-1H-pyrazol-1-yl)-1,3,7-trimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate In acetonitrile at 45℃; for 10h; Inert atmosphere; Electrochemical reaction; Green chemistry; diastereoselective reaction;	99%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 144-62-7
oxalic acid

: oxalic acid caffeine, oxalic acid

Conditions

Conditions	Yield
In methanol; cyclohexane at 17 - 22℃; under 724.572 - 782.178 Torr; for 0.5h;	98.3%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 32061-73-7
2,6-dithiocaffeine

Conditions

Conditions	Yield
With Lawessons reagent; aluminum oxide for 0.1h; microwave irradiation;	98%
With Lawessons reagent In toluene for 25h; Reflux;	75%
With bis(1,5-cyclooctadiylboryl)sulfide In 1,3,5-trimethyl-benzene for 336h; Heating;	62%
With kerosine

: 15199-43-6
d6-dimethyl sulfate

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: C9H10(2)H3N4O2(1+)*C(2)H3O4S(1-)

Conditions

Conditions	Yield
In nitrobenzene at 90 - 100℃; for 25h;	98%

: 64-17-5
ethanol

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 32086-89-8
8-(1-hydroxyethyl)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In decane at 120℃; for 0.333333h; Reagent/catalyst; Solvent; Temperature; Time; Microwave irradiation; Green chemistry;	98%
With di-tert-butyl peroxide In water at 20℃; Inert atmosphere; UV-irradiation;	96%
With benzophenone Ambient temperature; Irradiation;

: 108-86-1
bromobenzene

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 6439-88-9
1,3,7-trimethyl-8-phenylxanthine

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 20 - 120℃; for 7.16667h; Inert atmosphere;	98%
With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide at 20 - 140℃; for 36.1667h; Inert atmosphere; regioselective reaction;	93%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 573-17-1
9-bromophenanthrene

: 99765-06-7
3,7-Dihydro-1,3,7-trimethyl-8-(9-phenanthryl)-1H-purin-2,6-dion

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 20 - 120℃; for 7.16667h; Inert atmosphere;	98%
With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide at 20 - 140℃; for 36.1667h; Inert atmosphere; regioselective reaction;	95%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 1220356-33-1
8-deuterio-1,3,7-tris(trideuteriomethyl)xanthine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; water-d2 at 160℃; for 24h;	98%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 420-37-1
trimethoxonium tetrafluoroborate

: 1,3,7,9-tetramethylxanthinium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione; trimethoxonium tetrafluoroborate In acetonitrile at 20℃; for 0.0833333h; Inert atmosphere; Schlenk technique; Stage #2: With sodium carbonate In acetonitrile at 20℃; for 0.916667h;	97%
In 1,2-dichloro-ethane at 100℃; for 1h;	66%
In 1,2-dichloro-ethane Inert atmosphere; Schlenk technique; Reflux;

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 696-62-8
para-iodoanisole

: 439927-43-2
1,3,7-trimethyl-8-(p-methoxyphenyl)-xanthine

Conditions

Conditions	Yield
With (1-(2-(tert-butylamino)ethyl)-3-mesityl-2,3-dihydro-1H-imidazol-2-yl)copper(I) iodide; lithium tert-butoxide In N,N-dimethyl-formamide at 140℃; for 8h; Glovebox;	97%
With potassium phosphate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 20 - 120℃; for 7.16667h; Inert atmosphere;	92%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 15802-75-2
4-iodo-3-methyl-1H-pyrazole

: 4,5,8-tris(4-iodo-3-methyl-1H-pyrazol-1-yl)-1,3,7-trimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate In acetonitrile at 45℃; for 10h; Inert atmosphere; Electrochemical reaction; Green chemistry; diastereoselective reaction;	97%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 106-38-7
para-bromotoluene

: 1,3,7-trimethyl-8-(4-methylphenyl)-1H-purine-3,7-dihydro-2,6-dione

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 20 - 120℃; for 7.16667h; Inert atmosphere;	96%
With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide at 20 - 140℃; for 36.1667h; Inert atmosphere; regioselective reaction;	96%
With 2-ethyl-[1,2,4] triazolo[4,3-a]pyridin-2-ium tetrafluoroborate; palladium diacetate; potassium carbonate In N,N-dimethyl-formamide at 115℃; for 22h; Inert atmosphere;	94%

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 95-46-5
2-methylphenyl bromide

: 1137486-72-6
1,3,7-trimethyl-8-(o-tolyl)-xanthine

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 20 - 120℃; for 7.16667h; Inert atmosphere;	96%
With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide at 20 - 140℃; for 36.1667h; Inert atmosphere; regioselective reaction;	88%

: 554-14-3
2-Methylthiophene

: 58-08-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 1207995-92-3
1,3,7-trimethyl-8-(5-methylthiophen-2-yl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione

Conditions

Conditions	Yield
Stage #1: 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione With pyridine; palladium diacetate; copper(II) acetate monohydrate In 1,4-dioxane at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 2-Methylthiophene In 1,4-dioxane at 120℃; for 20h; Inert atmosphere;	96%
With pyridine; palladium diacetate; copper(II) acetate monohydrate In 1,4-dioxane at 120℃; for 24h; Schlenk technique; Inert atmosphere;	92%
With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxygen; copper(II) acetate monohydrate In 1,4-dioxane at 140℃; under 760.051 Torr; for 30h; Schlenk technique; Green chemistry;	89%

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