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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,6-Dihydroxy-3-methylpurine Manufacturer/High quality/Best price/In stock

Cas:1076-22-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Light yellow powder Light yellow powder Identification IR

High quality 3-Methylxanthine with best price cas:1076-22-8

Cas:1076-22-8

Min.Order:1 Kilogram

FOB Price: $250.0 / 350.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product Name 2,6-Dihydroxy-3-methylpurine CAS No. 1076-22-8 Appearance White to yellowish powder Assay ≥99% Capacity 100mt/year Min.packin

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of 2,6-Dihydroxy-3-methylpurine Cas 1076-22-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:White powder Package:25kg/drum Application:bioch

Manufacturer high quality 2,6-Dihydroxy-3-methylpurine Cas 1076-22-8 with good price

Cas:1076-22-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3,7-dihydro-3-methyl-1H-purine-2,6-dione

Cas:1076-22-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 2,6-Dihydroxy-3-methylpurine 1076-22-8 GMP Manufacturer

Cas:1076-22-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

2,6-Dihydroxy-3-methylpurine -- CHemwill

Cas:1076-22-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2, 6-Dihydroxy-3-Methylpurine CAS 1076-22-8

Cas:1076-22-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Pure CAS 1076-22-8 with competitive price

Cas:1076-22-8

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to Pale Beige powder Storage:2-8°C Package:25kg/drum Application:chemicals Transportation:Express/Sea/Air Port:any port in china

3-Methylxanthine factory price

Cas:1076-22-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

Linagliptin Intermediate 2,6-Dihydroxy-3-methylpurine CAS NO1076-22-8

Cas:1076-22-8

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Purine-2,6-dione,3,9-dihydro-3-methyl- 1076-22-8

Cas:1076-22-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2,6-Dihydroxy-3-methylpurine CAS:1076-22-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ

2,6-Dihydroxy-3-methylpurine CAS:1076-22-8

Cas:1076-22-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

1H-Purine-2,6-dione,3,9-dihydro-3-methyl-/ LIDE PHARMA- Factory supply / Best price

Cas:1076-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Purine-2,6-dione,3,9-dihydro-3-methyl-

Cas:1076-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

3-Methylxanthine

Cas:1076-22-8

Min.Order:10 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-Methyl Xanthine

Cas:1076-22-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS1076-22-8 2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

1H-?Purine-?2,?6-?dione,3,?9-?dihydro-?3-?methyl-

Cas:1076-22-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Methylxanthine

Cas:1076-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Lonwin Industry group limited as a professional manufactor & exporter of chemical materials ,we totally haver more than 230 stuffs, we have been on this line for more than 9 years. Our chemical materials are exported to lot of countries and re

Low price with good quality 3-Methylxanthine

Cas:1076-22-8

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,6-Dihydroxy-3-methylpurine

Cas:1076-22-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

4-(N-methylamino)-1H-imidazole-5-carboxamide
90801-87-9

4-(N-methylamino)-1H-imidazole-5-carboxamide

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With formic acid; perchloric acid adsorbed on silica gel In ethanol at 20℃; for 0.333333h; Solvent;95.12%
formic acid
64-18-6

formic acid

5,6-diamino-1-methyluracil
6972-82-3

5,6-diamino-1-methyluracil

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
Stage #1: formic acid; 5,6-diamino-1-methyluracil In water at 105℃; for 3h;
Stage #2: With sodium hydroxide In water at 105℃; for 1h;
94.1%
Stage #1: formic acid; 5,6-diamino-1-methyluracil In water for 3h; Reflux; Inert atmosphere;
Stage #2: With sodium hydroxide In water for 1h; Reflux; Inert atmosphere;
80%
Stage #1: formic acid; 5,6-diamino-1-methyluracil In water for 3h; Reflux; Inert atmosphere;
Stage #2: With sodium hydroxide In water at 20℃; for 1h; Inert atmosphere; Reflux;
78%
7-benzyl-3-methylxanthine
56025-86-6

7-benzyl-3-methylxanthine

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With 20 % Pd(OH)2/C; hydrogen In acetic acid; ethyl acetate at 90℃; under 75007.5 Torr; for 0.416667h; H-Cube reactor;90%
3-methylxanthine
3080-28-2

3-methylxanthine

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With hydrogenchloride In water for 0.5h; Ambient temperature;84%
With hydrogenchloride In water at 25℃; Rate constant; hydrolytic cleavage of the glycosidic bond in several HCl solutions;
1-methyl-2,4-dioxo-5,6-diaminopyrimidine hydrochloride
50996-13-9

1-methyl-2,4-dioxo-5,6-diaminopyrimidine hydrochloride

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 70℃; for 3.5h;53%
formaldehyd
50-00-0

formaldehyd

5,6-diamino-1-methyluracil
6972-82-3

5,6-diamino-1-methyluracil

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With acetic acid nachfolgenden Behandeln mit Eisenchlorid;
5,6-diamino-1-methyluracil
6972-82-3

5,6-diamino-1-methyluracil

3-methylxanthine
1076-22-8

3-methylxanthine

6-amino-1-methyl-5-nitrosouracil
6972-78-7

6-amino-1-methyl-5-nitrosouracil

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With palladium on activated charcoal; formic acid; isopropyl alcohol Erwaermen des Reaktionsprodukts mit wss.NaOH;
Multi-step reaction with 3 steps
1: 98 percent / H2 / 10percent Pd/C / H2O / 3750.3 Torr / Ambient temperature
2: 96 percent / 10percent Pd/C / 39.9 °C
3: NaOH
View Scheme
Multi-step reaction with 2 steps
1: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C
2: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min
View Scheme
5-acetylamino-6-amino-1-methyl-1H-pyrimidine-2,4-dione
10184-42-6

5-acetylamino-6-amino-1-methyl-1H-pyrimidine-2,4-dione

3-methylxanthine
1076-22-8

3-methylxanthine

(1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amidosulfuric acid
874495-58-6

(1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amidosulfuric acid

3-methylxanthine
1076-22-8

3-methylxanthine

formic acid
64-18-6

formic acid

6-amino-1-methyl-5-nitrosouracil
6972-78-7

6-amino-1-methyl-5-nitrosouracil

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
1.) electrolyse: formamide, platinum mesh as anode, tin plate as cathode, 30-35 deg C, current density 12.5 A/dm2, 2.) 180-200 deg C; Yield given. Multistep reaction;
theobromine /
83-67-0

theobromine /

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With sodium thiophenolate at 280℃; for 1.5h; Yield given;
3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine
14785-95-6

3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With sodium hydroxide
theophylline
58-55-9

theophylline

A

1-methylxanthine
6136-37-4

1-methylxanthine

B

3-methylxanthine
1076-22-8

3-methylxanthine

C

1,3-dimethyluric acid
944-73-0

1,3-dimethyluric acid

Conditions
ConditionsYield
With rat liver microsome; NADPH In phosphate buffer Enzyme kinetics; Further Variations:; inhibition by mexiletine and its metabolites; Oxidation;
3-methyl-8-chloro-xanthine

3-methyl-8-chloro-xanthine

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With phosphonium iodide; hydrogen iodide
With phosphonium iodide; hydrogen iodide
3-methyl-xanthine-carboxylic acid-(8)

3-methyl-xanthine-carboxylic acid-(8)

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
at 260℃;
sodium salt of 3-methyl-4-amino-formylamino-uracil

sodium salt of 3-methyl-4-amino-formylamino-uracil

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
at 220℃;
5,6-diamino-1-methyluracil
6972-82-3

5,6-diamino-1-methyluracil

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 96 percent / 10percent Pd/C / 39.9 °C
2: NaOH
View Scheme
1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-5-<(ethoxycarbonyl)methylamino>imidazole-4-carboxamide
81812-69-3

1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-5-<(ethoxycarbonyl)methylamino>imidazole-4-carboxamide

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 69 percent / 1N NaOH / H2O / 3 h / Ambient temperature
2: 0.1N HCl / H2O / 25 °C / hydrolytic cleavage of the glycosidic bond in several HCl solutions
View Scheme
1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-5-(methylamino)imidazole-4-carboxamide
68768-26-3

1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-5-(methylamino)imidazole-4-carboxamide

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 36 percent / AcONa / acetic acid / 5 h / 30 °C
2: 69 percent / 1N NaOH / H2O / 3 h / Ambient temperature
3: 0.1N HCl / H2O / 25 °C / hydrolytic cleavage of the glycosidic bond in several HCl solutions
View Scheme
theophylline
58-55-9

theophylline

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 10 percent / sodium thiophenolate / 1.5 h / 280 °C
2: sodium thiophenolate / 1.5 h / 280 °C
View Scheme
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
58-08-2

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 37 percent / sodium thiophenolate / 1.5 h / 250 °C
2: 10 percent / sodium thiophenolate / 1.5 h / 280 °C
3: sodium thiophenolate / 1.5 h / 280 °C
View Scheme
Multi-step reaction with 2 steps
1: 21 percent / sodium thiophenolate / 1.5 h / 250 °C
2: sodium thiophenolate / 1.5 h / 280 °C
View Scheme
6-amino-1-methyluracil
2434-53-9

6-amino-1-methyluracil

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaNO2, AcOH / H2O / 2 h / Ambient temperature
2: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C
3: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; sodium nitrite / water / 1.5 h / 20 - 50 °C
2.1: ammonium hydroxide; sodium dithionite / 7 h / 25 - 60 °C
3.1: water / 3 h / 105 °C
3.2: 1 h / 105 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium dithionite; ammonium hydroxide / 1 h / 50 °C
2.1: water / 3 h / Reflux; Inert atmosphere
2.2: 1 h / Reflux; Inert atmosphere
View Scheme
theophylline
58-55-9

theophylline

A

5,6-diaminouracil
3240-72-0

5,6-diaminouracil

B

3-methylxanthine
1076-22-8

3-methylxanthine

C

1,3-dimethyluric acid
127091-92-3

1,3-dimethyluric acid

D

1-methylxanthine

1-methylxanthine

E

1-methyluric acid

1-methyluric acid

F

3-methyluric acid

3-methyluric acid

G

3-methyltetrahydro-1H-purine-2,6-dione

3-methyltetrahydro-1H-purine-2,6-dione

H

1-methyltetrahydro-1H-purine-2,6-dione

1-methyltetrahydro-1H-purine-2,6-dione

I

xanthin
69-89-6

xanthin

Conditions
ConditionsYield
With dihydrogen peroxide at 20℃; for 0.133333h; pH=6; Kinetics; UV-irradiation;
5,6-diamino-1-methyluracil
6972-82-3

5,6-diamino-1-methyluracil

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 70℃; for 3.5h; Inert atmosphere;
C6H8N4O4

C6H8N4O4

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
With sodium hydroxide In water at 70 - 95℃; for 1h; pH=1.5; pH-value; Temperature;
N-cyanoacetyl-N'-methyl-urea
6972-77-6

N-cyanoacetyl-N'-methyl-urea

3-methylxanthine
1076-22-8

3-methylxanthine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 0.5 h / 95 °C / pH 8
2.1: sodium nitrite / 2.5 h / 20 °C / pH 8
2.2: 3 h / 50 °C
3.1: sodium hydroxide / water / 1 h / 70 - 95 °C / pH 1.5
View Scheme
3-methylxanthine
1076-22-8

3-methylxanthine

3-methyl-8-bromoxanthine
93703-24-3

3-methyl-8-bromoxanthine

Conditions
ConditionsYield
With bromine; sodium acetate In acetic acid at 50 - 65℃; for 3h;96.6%
With bromine; acetic acid at 100℃; for 6h;95%
With bromine; sodium acetate; acetic acid at 65℃; for 3h;94.17%
3-methylxanthine
1076-22-8

3-methylxanthine

but-2-yn-1-yl methanesulfonate
61493-85-4

but-2-yn-1-yl methanesulfonate

7-but-2-ynyl-3-methyl-3,7-dihydro-purine-2,6-dione

7-but-2-ynyl-3-methyl-3,7-dihydro-purine-2,6-dione

Conditions
ConditionsYield
With potassium hydrogencarbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 7.75h;94%
3-methylxanthine
1076-22-8

3-methylxanthine

dimethyl sulfate
77-78-1

dimethyl sulfate

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
58-08-2

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Conditions
ConditionsYield
With tetramethyl ammoniumhydroxide; potassium carbonate In methanol; water at 65 - 70℃;92.5%
3-methylxanthine
1076-22-8

3-methylxanthine

ethyl iodide
75-03-6

ethyl iodide

1,7-diethyl-3-methylxanthine
54889-96-2

1,7-diethyl-3-methylxanthine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide for 4h;92%
3-methylxanthine
1076-22-8

3-methylxanthine

p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

3,7-dihydro-7-(4-methoxybenzyl)-3-methyl-1H-purine-2,6-dione
143958-73-0

3,7-dihydro-7-(4-methoxybenzyl)-3-methyl-1H-purine-2,6-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 2h;90%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1.5h;
3-methylxanthine
1076-22-8

3-methylxanthine

7-(6-hydroxy-hexyl)-3-methyl-3,7-dihydro-purine-2,6-dione
56395-72-3

7-(6-hydroxy-hexyl)-3-methyl-3,7-dihydro-purine-2,6-dione

Conditions
ConditionsYield
With sodium hydroxide In methanol; water90%
3-methylxanthine
1076-22-8

3-methylxanthine

(bromomethylcyclohexane)
2550-36-9

(bromomethylcyclohexane)

7-(cyclohexylmethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

7-(cyclohexylmethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

Conditions
ConditionsYield
Stage #1: 3-methylxanthine With sodium hydride In dimethyl sulfoxide; mineral oil at 0 - 80℃; for 0.5h;
Stage #2: Cyclohexylmethyl bromide In dimethyl sulfoxide; mineral oil at 80℃; for 12h; Inert atmosphere;
89%
3-methylxanthine
1076-22-8

3-methylxanthine

benzyl bromide
100-39-0

benzyl bromide

7-benzyl-3-methylxanthine
56025-86-6

7-benzyl-3-methylxanthine

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 60℃; for 12h;88%
In methanol; sodium hydroxide; water
In methanol; sodium hydroxide; water
3-methylxanthine
1076-22-8

3-methylxanthine

dimethyl sulfate
77-78-1

dimethyl sulfate

theobromine /
83-67-0

theobromine /

Conditions
ConditionsYield
Stage #1: 3-methylxanthine; dimethyl sulfate With sodium hydrogencarbonate In water; acetone at 55 - 60℃; for 4h;
Stage #2: With hydrogenchloride In water at 80℃; pH=5 - 6; Product distribution / selectivity;
87%
2-iodo-propane
75-30-9

2-iodo-propane

3-methylxanthine
1076-22-8

3-methylxanthine

1,7-diisopropyl-3-methylxanthine

1,7-diisopropyl-3-methylxanthine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide for 4h;87%
3-methylxanthine
1076-22-8

3-methylxanthine

ethyl iodide
75-03-6

ethyl iodide

3-methyl-7-ethyl-xanthine
55242-68-7

3-methyl-7-ethyl-xanthine

Conditions
ConditionsYield
Stage #1: 3-methylxanthine With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 0.5h;
Stage #2: ethyl iodide In N,N-dimethyl-formamide for 5h;
86%
3-methylxanthine
1076-22-8

3-methylxanthine

2-chloro-N-(2-(6-bromo)pyridinyl)acetamide
629616-88-2

2-chloro-N-(2-(6-bromo)pyridinyl)acetamide

N-(6-bromopyridin-2-yl)-2-(3-methyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)acetamide

N-(6-bromopyridin-2-yl)-2-(3-methyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;83.7%
3-methylxanthine
1076-22-8

3-methylxanthine

3-methyl-8-nitroxanthine
93703-23-2

3-methyl-8-nitroxanthine

Conditions
ConditionsYield
With nitric acid In acetic acid at 120℃; for 1.5h;83%
With nitric acid; acetic acid 1.) 100 deg C, 30 min, 2.) reflux, 15 min;63%
3-methylxanthine
1076-22-8

3-methylxanthine

2-chloro-N-(2-(6-methyl-5-(trifluoromethyl)pyridin-3-yl)-1,3-thiazol-4-yl)acetamide

2-chloro-N-(2-(6-methyl-5-(trifluoromethyl)pyridin-3-yl)-1,3-thiazol-4-yl)acetamide

2-(3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)-N-(2-(6-methyl-5-(trifluoromethyl)pyridin-3-yl)-1,3-thiazol-4-yl)acetamide

2-(3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)-N-(2-(6-methyl-5-(trifluoromethyl)pyridin-3-yl)-1,3-thiazol-4-yl)acetamide

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 50℃; for 2h; Inert atmosphere;83%
3-methylxanthine
1076-22-8

3-methylxanthine

3,4-dibenzyloxybenzyl chloride
1699-59-8

3,4-dibenzyloxybenzyl chloride

C48H42N4O6

C48H42N4O6

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; sodium hydride In N,N-dimethyl-formamide at 60℃; for 12h;78%
With tetra-(n-butyl)ammonium iodide; sodium hydride In N,N-dimethyl-formamide at 60℃; for 12h;78%
3-methylxanthine
1076-22-8

3-methylxanthine

A

3-methyl-7-aminoxanthine
120642-74-2

3-methyl-7-aminoxanthine

B

3-methyl-1,7-diaminoxanthine
120642-75-3

3-methyl-1,7-diaminoxanthine

Conditions
ConditionsYield
With potassium hydroxide; sodium hydrogencarbonate; hydroxylamine-O-sulfonic acid In water at 50 - 60℃; for 0.666667h;A 67%
B 7%
With potassium hydroxide; sodium hydrogencarbonate; hydroxylamine-O-sulfonic acid In water at 50℃; for 0.166667h;A 67%
B 7%
3-methylxanthine
1076-22-8

3-methylxanthine

methyl iodide
74-88-4

methyl iodide

A

theobromine /
83-67-0

theobromine /

B

1,7,9-trimethylxanthinium iodide
86180-33-8

1,7,9-trimethylxanthinium iodide

Conditions
ConditionsYield
at 110℃; for 1.5h; closed Kjeldahl flask;A 61%
B 28%
3-methylxanthine
1076-22-8

3-methylxanthine

1,6-dichlorohexane
2163-00-0

1,6-dichlorohexane

1,7-Bis(ω-chlorohexyl)-3-methyl-xanthine
125663-71-0

1,7-Bis(ω-chlorohexyl)-3-methyl-xanthine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 85 - 105℃;60%
1,5-dichloropentane
628-76-2

1,5-dichloropentane

3-methylxanthine
1076-22-8

3-methylxanthine

1,7-Bis(ω-chloropentyl)-3-methyl-xanthine
125663-70-9

1,7-Bis(ω-chloropentyl)-3-methyl-xanthine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 85 - 105℃;58%
3-methylxanthine
1076-22-8

3-methylxanthine

1,4-dichlorobutane
110-56-5

1,4-dichlorobutane

1,7-Bis(ω-chlorobutyl)-3-methyl-xanthine
125663-69-6

1,7-Bis(ω-chlorobutyl)-3-methyl-xanthine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 85 - 105℃;55%
3-methylxanthine
1076-22-8

3-methylxanthine

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-(3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetate

ethyl 2-(3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetate

Conditions
ConditionsYield
Stage #1: 3-methylxanthine With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h; Inert atmosphere;
Stage #2: ethyl bromoacetate In N,N-dimethyl-formamide at 20℃; for 19h;
55%
2-(Bromomethyl)pyridine
55401-97-3

2-(Bromomethyl)pyridine

3-methylxanthine
1076-22-8

3-methylxanthine

N-(2-bromo-1,3-thiazol-4-yl)-2-chloroacetamide

N-(2-bromo-1,3-thiazol-4-yl)-2-chloroacetamide

N-(2-bromo-1,3-thiazol-4-yl)-2-(3-methyl-2,6-dioxo-1-(pyridin-2-ylmethyl)-2,3-dihydro-1H-purin-7(6H)-yl)acetamide

N-(2-bromo-1,3-thiazol-4-yl)-2-(3-methyl-2,6-dioxo-1-(pyridin-2-ylmethyl)-2,3-dihydro-1H-purin-7(6H)-yl)acetamide

Conditions
ConditionsYield
Stage #1: 3-methylxanthine; N-(2-bromo-1,3-thiazol-4-yl)-2-chloroacetamide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;
Stage #2: 2-(Bromomethyl)pyridine With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 2h; Inert atmosphere;
54%
3-methylxanthine
1076-22-8

3-methylxanthine

1,3-Dichloropropane
142-28-9

1,3-Dichloropropane

1,7-Bis(γ-chloropropyl)-3-methyl-xanthine
125663-68-5

1,7-Bis(γ-chloropropyl)-3-methyl-xanthine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 85 - 105℃;53%
1-iodo-butane
542-69-8

1-iodo-butane

3-methylxanthine
1076-22-8

3-methylxanthine

7-butyl-3-methyl-1H-purine-2,6(3H,7H)-dione
55242-69-8

7-butyl-3-methyl-1H-purine-2,6(3H,7H)-dione

Conditions
ConditionsYield
Stage #1: 3-methylxanthine With potassium hydroxide In methanol; water at 80℃; for 1.5h;
Stage #2: 1-iodo-butane In methanol; water at 50℃; for 24h;
52%
1,10-dichlorodecane
2162-98-3

1,10-dichlorodecane

3-methylxanthine
1076-22-8

3-methylxanthine

1,7-Bis(ω-chlorodecyl)-3-methyl-xanthine
125663-72-1

1,7-Bis(ω-chlorodecyl)-3-methyl-xanthine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 85 - 105℃;51%
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