Product Name

  • Name

    Etilefrine hydrochloride

  • EINECS 213-398-8
  • CAS No. 943-17-9
  • Density 1.127g/cm3
  • Solubility
  • Melting Point 122 °C
  • Formula C10H16ClNO2
  • Boiling Point 351.7 °C at 760 mmHg
  • Molecular Weight 217.696
  • Flash Point 155.5 °C
  • Transport Information
  • Appearance white
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 943-17-9 (Etilefrine hydrochloride)
  • Hazard Symbols
  • Synonyms Benzenemethanol,a-[(ethylamino)methyl]-3-hydroxy-,hydrochloride (9CI);Benzyl alcohol, a-[(ethylamino)methyl]-m-hydroxy-, hydrochloride(6CI,8CI);Apocretin;Circupon;Effontil;Effortilvet;Ethyl adrianol;Ethylephrine hydrochloride;Eti-Puren;Funasol;Kertasin;Phetanol;Pulsamin;Tonus-Forte;Updormin;dl-1-(3-Hydroxyphenyl)-1-hydroxy-2-ethylaminoethane hydrochloride;dl-Ethylphenylephrine hydrochloride;
  • PSA 57.07000
  • LogP -2.98710

Synthetic route

Apocretin
943-17-9

Apocretin

(+)-<(R)-Tetrahydrofurfuryl-(1S)-campher-sulfonat>

(+)-<(R)-Tetrahydrofurfuryl-(1S)-campher-sulfonat>

N-<(R)-Tetrahydrofurfuryl>-(+/-)-etilefrin

N-<(R)-Tetrahydrofurfuryl>-(+/-)-etilefrin

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 100℃; for 10h;94%
Apocretin
943-17-9

Apocretin

N-Ethyl-2-chloro-2-(3-hydroxyphenyl)ethylamine hydrochloride
119610-62-7

N-Ethyl-2-chloro-2-(3-hydroxyphenyl)ethylamine hydrochloride

Conditions
ConditionsYield
With thionyl chloride In benzene at 40 - 45℃; for 1h;46%
Apocretin
943-17-9

Apocretin

1-(3-Hydroxyphenyl)-2-ethylaminoethylthiophosphoric acid
119610-65-0

1-(3-Hydroxyphenyl)-2-ethylaminoethylthiophosphoric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 46 percent / SOCl2 / benzene / 1 h / 40 - 45 °C
2: 18 percent / Na3SPO3*12H2O / H2O / 4 h
View Scheme
Apocretin
943-17-9

Apocretin

1-(3-Hydroxyphenyl)-2-ethylaminoethylthiosulfuric acid
119610-63-8

1-(3-Hydroxyphenyl)-2-ethylaminoethylthiosulfuric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 46 percent / SOCl2 / benzene / 1 h / 40 - 45 °C
2: 57 percent / Na2S2O3*5H2O / H2O / 1.) 40 deg C, 3 h, 2.) 60 deg C, 4 h
View Scheme
copper(II) choride dihydrate

copper(II) choride dihydrate

Apocretin
943-17-9

Apocretin

Cu(α-[(etylamino)methyl]-3-hydroxy-benzenemethanol)2
307975-81-1

Cu(α-[(etylamino)methyl]-3-hydroxy-benzenemethanol)2

Conditions
ConditionsYield
In water at excess of ligand (1:2-1:10) and pH=10.5;
methanol
67-56-1

methanol

copper(II) choride dihydrate

copper(II) choride dihydrate

Apocretin
943-17-9

Apocretin

Cu2(α-[(etylamino)methyl]-3-hydroxy-benzenemethanol)2Cl2
307975-83-3

Cu2(α-[(etylamino)methyl]-3-hydroxy-benzenemethanol)2Cl2

Conditions
ConditionsYield
With NaOH In methanol ligand dissolved in MeOH, added methanolic solns. of CuCl2*2H2O and NaOHat molar ratio Cu-ligand-NaOH=1:2:2, allowed to stand for 3 d; filtered, washed with MeOH, dried over P2O5, elem. anal.;
methanol
67-56-1

methanol

copper(II) choride dihydrate

copper(II) choride dihydrate

Apocretin
943-17-9

Apocretin

Cu(α-[(ethylamino)methyl]-3-hydroxy-benzenemethanol)2*2MeOH

Cu(α-[(ethylamino)methyl]-3-hydroxy-benzenemethanol)2*2MeOH

Conditions
ConditionsYield
With NaOH In methanol ligand dissolved in MeOH, added methanolic solns. of CuCl2*2H2O and NaOHat molar ratio Cu-ligand-NaOH=1:10:20, allowed to stand for 4 mo; filtered, washed, dried over P2O5, elem. anal.;

Etilefrine hydrochloride Chemical Properties

Product Name: Etilefrine hydrochloride (CAS NO.943-17-9)

MF: C10H16ClNO2
MW: 217.69
Melting Point: 122 °C
EINECS: 213-398-8
Flash Point: 155.5 °C
Enthalpy of Vaporization: 62.94 kJ/mol 
Boiling Point: 351.7 °C at 760 mmHg 
Vapour Pressure: 1.5E-05 mmHg at 25°C 
H-Bond Donor: 4
H-Bond Acceptor: 3
Structure Descriptors of Etilefrine hydrochloride (CAS NO.943-17-9):
  IUPAC Name: 3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride
  Canonical SMILES: CCNCC(C1=CC(=CC=C1)O)O.Cl
  InChI: InChI=1S/C10H15NO2.ClH/c1-2-11-7-10(13)8-4-3-5-9(12)6-8;/h3-6,10-13H,2,7H2,1H3;1H 
  InChIKey: KTNROWWHOBZQGK-UHFFFAOYSA-N
Classification Code: Drug / Therapeutic Agent

Etilefrine hydrochloride Toxicity Data With Reference

1.    

orl-rat LDLo:187 mg/kg

    DRFUD4    Drugs of the Future. 4 (1979),413.
2.    

ivn-rat LDLo:5 mg/kg

    DRFUD4    Drugs of the Future. 4 (1979),413.
3.    

orl-mus LDLo:345 mg/kg

    DRFUD4    Drugs of the Future. 4 (1979),413.
4.    

ivn-mus LDLo:11 mg/kg

    DRFUD4    Drugs of the Future. 4 (1979),413.

Etilefrine hydrochloride Safety Profile

Poison by ingestion and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also ALCOHOL, DENATURED; ALCOHOLS, C6-12; ALCOHOLS, C9-11; ALCOHOLS, C12-13, ETHOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED; ALCOHOLS, C12-16, ETHOXYLATED; ALCOHOLS, C14-15, ETHOXYLATED; ALCOHOLS, C16-18, ETHOXYLATED; ALCOHOLS, C8-10, ETHOXYLATED PROPOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED PROPOXYLATED; ALCOHOLS, N.O.S.
Safety information of Etilefrine hydrochloride (CAS NO.943-17-9):
RTECS  DO5618000

Etilefrine hydrochloride Specification

 Etilefrine hydrochloride , its CAS NO. is 943-17-9, the synonyms are alpha.-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride ; 3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride ; Effortil ; Efortil ; Etilefrin dl-form hydrochloride ; ( -)-Ethylphenylephrine hydrochloride ; ( -)-N-Ethylnorphenylephrine hydrochloride ; 1-(3-Hydroxyphenyl)-2-ethylaminoethanol hydrochloride .  

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