-
Name
(59S)-57-Demethyl-45-de(2-methyl-1-oxopropyloxy)-59-deoxo-59-methoxy-45-methoxy-12-O-(3-C,4-O-dimethyl-3-nitro-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)flambamycin
- EINECS
- CAS No. 53296-30-3
- Density 1.49g/cm3
- Solubility
- Melting Point 184.5°C
- Formula C66H99Cl2NO36
- Boiling Point °Cat760mmHg
- Molecular Weight 1553.56
- Flash Point °C
- Transport Information
- Appearance
- Safety Moderately toxic by intraperitoneal, subcutaneous and intravenous routes. When heated to decomposition it emits toxic fumes of Cl− and NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms R-451-B;Everninomycin-B;
- PSA 433.48000
- LogP 1.26020
Everninomycin-B Chemical Properties
IUPAC Name: [6-[4',7-dihydroxy-6-[3-hydroxy-2-[4-hydroxy-6-[7'-hydroxy-7-methoxy-7'-(1-methoxyethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,4'-6,7a-dihydro-3aH-[1,3]dioxolo[4,5-c]pyran]-6-yl]oxy-5-methoxy-2-(methoxymethyl)oxan-3-yl]oxy-5-methoxy-6-methyloxan-4-yl]oxy-2',4,7a-trimethylspiro[3a,4,6,7-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2,6'-oxane]-3'-yl]oxy-4-(5-methoxy-4,6-dimethyl-4-nitrooxan-2-yl)oxy-2-methyloxan-3-yl] 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate
Synonyms of Everninomycin-B (CAS NO.53296-30-3): R-451-B ; beta-D-Mannopyranoside, O-4-C-(1-methoxyethyl)-2,3-O-methylenepentopyranosylidene-(1-3-4)-2-O-methyl-alpha-L-lyxopyranosyl O-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitro-alpha-L-arabino-hexopyranosyl-(1-3)-O-2,6-dideoxy-4-O-(3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoyl)-beta-D-arabino-hexopyranosyl-(1-4)-0-2,6-dideoxy-D-ribo-hexopyranosylidene-(1-3-4)-O-6-deoxy-3-C-methyl-beta-D-mannopyranosyl-(1-3)-O-6-deoxy-4-O-methyl-beta-D-galactopyranosyl-(1-4)-2,6-di-O-methyl-
CAS NO: 53296-30-3
Molecular Formula: C66H99Cl2NO36
Molecular Weight : 1553.3834
Molecular Structure: .png)
H bond acceptors: 37
H bond donors: 6
Freely Rotating Bonds: 29
Polar Surface Area: 367.48 Å2
Index of Refraction: 1.596
Molar Refractivity: 353.5 cm3
Molar Volume: 1037.7 cm3
Surface Tension: 68.5 dyne/cm
Density: 1.49 g/cm3
Everninomycin-B Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 880mg/kg (880mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 354, 1980. | |
| mouse | LD50 | intravenous | 875mg/kg (875mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 354, 1980. | |
| mouse | LD50 | subcutaneous | 1700mg/kg (1700mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 354, 1980. |
Everninomycin-B Safety Profile
Moderately toxic by intraperitoneal, subcutaneous and intravenous routes. When Everninomycin-B (CAS NO.53296-30-3) is heated to decomposition, it emits toxic fumes of Cl− and NOx.
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