Product Name

  • Name

    Fludarabine phosphate

  • EINECS 616-242-0
  • CAS No. 75607-67-9
  • Article Data9
  • CAS DataBase
  • Density 2.39 g/cm3
  • Solubility Soluble in DMSO or water at 5mg/ml
  • Melting Point 203°C(dec.)(lit.)
  • Formula C10H13FN5O7P
  • Boiling Point 864.2 °C at 760 mmHg
  • Molecular Weight 365.215
  • Flash Point 476.4 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes R25
  • Molecular Structure Molecular Structure of 75607-67-9 (Fludarabine phosphate)
  • Hazard Symbols T
  • Synonyms Fludarabine phosphate (JAN/USP);Fludarabine 5-monophosphate;9-beta-D-Arabinofuranosyl-2-fluoroadenine 5-(dihydrogen phosphate);Trimeric Sodium Phosphate;[(2R,3R,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid;2-Fluoro-ARA AMP;Fludarabine phosphate [USAN:BAN];Fludarabine monophosphate;9-beta-Arabinofuranosyl-2-fluoroadenine-5-phosphate;Fludura;9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-;2-Fluoroadenine arabinoside 5-monophosphate;fludarabine hcl;
  • PSA 195.88000
  • LogP -1.14270

Fludarabine phosphate Chemical Properties


IUPAC Name: [5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Molecular Formula: C10H13FN5O7P
Molecular Weight: 365.21 g/mol
Classification Code: Antimetabolites; Antimetabolites, antineoplastic; Antineoplastic; Antineoplastic Agents; Drug / Therapeutic Agent; Human Data; Immunologic Factors; Immunosuppressive agents; Noxae
Product Categories: Active Pharmaceutical Ingredients; Antineoplastics; Antineoplastic; API
XLogP3: -3.1
H-Bond Donor: 5
H-Bond Acceptor: 12
Surface Tension: 130.7 dyne/cm
Density: 2.39 g/cm3
Flash Point: 476.4 °C
Enthalpy of Vaporization: 131.58 kJ/mol
Boiling Point: 864.2 °C at 760 mmHg
Vapour Pressure of Fludarabine phosphate (CAS NO.75607-67-9): 7.38E-32 mmHg at 25 °C

Fludarabine phosphate Uses

 Fludarabine phosphate (CAS NO.75607-67-9) is a chemotherapy drug used in the treatment of hematological malignancies. It is highly effective in the treatment of chronic lymphocytic leukemia.

Fludarabine phosphate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 18750mg/kg/5D (18750mg/kg) BRAIN AND COVERINGS: ENCEPHALITIS
SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE		 Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986.
man TDLo intravenous 11655mg/kg/5D (11655mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Cancer Treatment Reports. Vol. 70, Pg. 1449, 1986.
man TDLo intravenous 17760mg/kg/5D (17760mg/kg) BRAIN AND COVERINGS: DEMYELINATION
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: COMA		 Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986.
mouse LD50 intravenous 1236mg/kg (1236mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) National Technical Information Service. Vol. PB83-195685,
women LDLo intravenous 14245mg/kg/5D (14245mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: EXCITEMENT
SKIN AND APPENDAGES (SKIN): SWEATING: OTHER		 Cancer Treatment Reports. Vol. 70, Pg. 1449, 1986.
women TDLo intravenous 23125mg/kg/5D (23125mg/kg) BRAIN AND COVERINGS: ENCEPHALITIS
SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986

Fludarabine phosphate Specification

  Fludarabine phosphate (CAS NO.75607-67-9), its Synonyms are Fludarabine monophosphate ; 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine ; 2-Fluoro-ARA AMP ; 2-Fluoroadenine arabinoside 5'-monophosphate ; 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate ; 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate) ; 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate ; Fludara ; 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)- .

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