Product Name

  • Name

    Fludrocortisone acetate

  • EINECS 208-180-4
  • CAS No. 514-36-3
  • Density 1.3 g/cm3
  • Solubility 54mg/L(25 oC)
  • Melting Point 233-234 °C
  • Formula C23H31FO6
  • Boiling Point 575.1 °C at 760 mmHg
  • Molecular Weight 422.494
  • Flash Point 301.6 °C
  • Transport Information
  • Appearance Crystalline solid
  • Safety 22-26-36
  • Risk Codes 63
  • Molecular Structure Molecular Structure of 514-36-3 (Fludrocortisone acetate)
  • Hazard Symbols HarmfulXn
  • Synonyms Fludrocortisone Acetate;Corticosterone,9-fluoro-17-hydroxy-, 21-acetate (6CI);Pregn-4-ene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-, 21-acetate(7CI,8CI);9-Fluorohydrocortisone acetate;9a-Fluoro-11b,17a,21-trihydroxypregn-4-ene-3,20-dione21-acetate;9a-Fluorocortisol21-acetate;9a-Fluorocortisolacetate;9a-Fluorohydrocortisone 21-acetate;9a-Fluorohydrocortisone acetate;Alflorone acetate;Cortineff;Fludrocortisone 21-acetate;Fludrocortisoneacetate;NSC 15186;Scherofluron;U 4845;
  • PSA 100.90000
  • LogP 2.44450

Synthetic route

9β,11β-epoxy-17α-hydroxypregna-4‐ene-3,20-dione-21-acetate
4383-30-6

9β,11β-epoxy-17α-hydroxypregna-4‐ene-3,20-dione-21-acetate

fludrocortisone acetate
514-36-3

fludrocortisone acetate

Conditions
ConditionsYield
With pyridine hydrogenfluoride In dichloromethane at 0 - 10℃; for 2h; Reagent/catalyst; Solvent;57.4%
21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione
4383-30-6, 96843-90-2

21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione

fludrocortisone acetate
514-36-3

fludrocortisone acetate

Conditions
ConditionsYield
With hydrogen fluoride
chloroform
67-66-3

chloroform

hydrogen fluoride
7664-39-3

hydrogen fluoride

21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione
4383-30-6, 96843-90-2

21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione

A

fludrocortisone acetate
514-36-3

fludrocortisone acetate

B

21-acetoxy-11β,17-dihydroxy-pregna-4,8(14)-diene-3,20-dione
96843-89-9

21-acetoxy-11β,17-dihydroxy-pregna-4,8(14)-diene-3,20-dione

...Expand
Epicortisol
566-35-8

Epicortisol

fludrocortisone acetate
514-36-3

fludrocortisone acetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dann mit Methansulfonylchlorid
2: sodium acetate; acetic acid
3: HClO4; aqueous dioxane
4: dioxane; potassium acetate; ethanol
5: HF
View Scheme
anecortave
7753-60-8

anecortave

fludrocortisone acetate
514-36-3

fludrocortisone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: HClO4; aqueous dioxane
2: dioxane; potassium acetate; ethanol
3: HF
View Scheme
21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione
50733-54-5

21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione

fludrocortisone acetate
514-36-3

fludrocortisone acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dioxane; potassium acetate; ethanol
2: HF
View Scheme
21-acetoxy-17-hydroxy-11α-methanesulfonyloxy-pregn-4-ene-3,20-dione
113862-93-4

21-acetoxy-17-hydroxy-11α-methanesulfonyloxy-pregn-4-ene-3,20-dione

fludrocortisone acetate
514-36-3

fludrocortisone acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium acetate; acetic acid
2: HClO4; aqueous dioxane
3: dioxane; potassium acetate; ethanol
4: HF
View Scheme
methanol
67-56-1

methanol

fludrocortisone acetate
514-36-3

fludrocortisone acetate

9-fluoro-11β-hydroxy-21,21-dimethoxy-pregn-4-ene-3,20-dione
125544-23-2

9-fluoro-11β-hydroxy-21,21-dimethoxy-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
With hydrogenchloride; chloroform
formaldehyd
50-00-0

formaldehyd

fludrocortisone acetate
514-36-3

fludrocortisone acetate

(20Ξ)-9-fluoro-11β-hydroxy-17,20;20,21-bis-methylenedioxy-pregn-4-en-3-one
2821-53-6

(20Ξ)-9-fluoro-11β-hydroxy-17,20;20,21-bis-methylenedioxy-pregn-4-en-3-one

Conditions
ConditionsYield
With hydrogenchloride; chloroform
fludrocortisone acetate
514-36-3

fludrocortisone acetate

9-fluoro-1ξ,11β,17,21-tetrahydroxy-pregn-4-ene-3,20-dione
805-91-4

9-fluoro-1ξ,11β,17,21-tetrahydroxy-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
mit Hilfe von Streptomyces-Kulturen;
fludrocortisone acetate
514-36-3

fludrocortisone acetate

Fludrocortisone
127-31-1

Fludrocortisone

Conditions
ConditionsYield
With potassium carbonate
fludrocortisone acetate
514-36-3

fludrocortisone acetate

21-acetoxy-9-fluoro-17-hydroxy-pregn-4-ene-3,11,20-trione
382-63-8

21-acetoxy-9-fluoro-17-hydroxy-pregn-4-ene-3,11,20-trione

Conditions
ConditionsYield
With chromium(VI) oxide
fludrocortisone acetate
514-36-3

fludrocortisone acetate

isoflupredone
338-95-4

isoflupredone

Conditions
ConditionsYield
With didymella lycopersicin
Multi-step reaction with 3 steps
1: palladium / Hydrogenation
2: bromine; acetic acid / Erhitzen des Reaktionsprodukts mit 2,4,6-Trimethyl-pyridin
3: aqueous methanol.K2CO3
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

21-acetoxy-9-fluoro-11β,17-dihydroxy-5α-pregnane-3,20-dione
1812-91-5

21-acetoxy-9-fluoro-11β,17-dihydroxy-5α-pregnane-3,20-dione

Conditions
ConditionsYield
With palladium Hydrogenation;
fludrocortisone acetate
514-36-3

fludrocortisone acetate

isoflupredone acetate
338-98-7

isoflupredone acetate

Conditions
ConditionsYield
With selenium(IV) oxide
With periodic acid
Multi-step reaction with 2 steps
1: didymella lycopersicin
2: pyridine
View Scheme
Multi-step reaction with 2 steps
1: palladium / Hydrogenation
2: bromine; acetic acid / Erhitzen des Reaktionsprodukts mit 2,4,6-Trimethyl-pyridin
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

acetyl chloride
75-36-5

acetyl chloride

11β,17,21-Triacetoxy-3-chlor-9α-fluor-pregna-3,5-dien-20-on
864-24-4

11β,17,21-Triacetoxy-3-chlor-9α-fluor-pregna-3,5-dien-20-on

Conditions
ConditionsYield
With trichlorophosphate
fludrocortisone acetate
514-36-3

fludrocortisone acetate

1ξ,21-diacetoxy-9-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione
2991-63-1

1ξ,21-diacetoxy-9-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: mit Hilfe von Streptomyces-Kulturen
2: pyridine
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

21-acetoxy-9-fluoro-11β,17-dihydroxy-5α-pregn-1-ene-3,20-dione
338-97-6

21-acetoxy-9-fluoro-11β,17-dihydroxy-5α-pregn-1-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium / Hydrogenation
2: bromine / dann mit Semicarbazid und anschliessend mit Brenztraubensaeure
View Scheme
Multi-step reaction with 2 steps
1: palladium / Hydrogenation
2: bromine; 2,4,6-trimethyl-pyridine
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

21-acetoxy-9-fluoro-11β,17-dihydroxy-pregna-4,6-diene-3,20-dione
564-57-8

21-acetoxy-9-fluoro-11β,17-dihydroxy-pregna-4,6-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium / Hydrogenation
2: bromine / Erhitzen des Reaktionsprodukts mit 2,4,6-Trimethyl-pyridin
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

9-fluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione
426-20-0

9-fluoro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: palladium / Hydrogenation
2: bromine; acetic acid / Erhitzen des Reaktionsprodukts mit 2,4,6-Trimethyl-pyridin
3: aqueous methanol.K2CO3
5: NaI; acetic acid
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

9α-Fluoro-11β,17α,21-trihydroxypregna-4,6-diene-3,20-dione
599-21-3

9α-Fluoro-11β,17α,21-trihydroxypregna-4,6-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium / Hydrogenation
2: bromine / Erhitzen des Reaktionsprodukts mit 2,4,6-Trimethyl-pyridin
3: aqueous methanol.K2CO3
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

21-acetoxy-2ξ-bromo-9-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione
631-76-5

21-acetoxy-2ξ-bromo-9-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium / Hydrogenation
2: bromine / dann mit 2,4,6-Trimethyl-pyridin
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

21-acetoxy-2-bromo-9-fluoro-11β,17-dihydroxy-5α-pregn-1-ene-3,20-dione
564-51-2

21-acetoxy-2-bromo-9-fluoro-11β,17-dihydroxy-5α-pregn-1-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium / Hydrogenation
2: bromine; 2,4,6-trimethyl-pyridine
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

9α-fluoroprednisolone acetate
338-99-8

9α-fluoroprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium / Hydrogenation
2: bromine; acetic acid / Erhitzen des Reaktionsprodukts mit 2,4,6-Trimethyl-pyridin
3: CrO3
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

9-fluoro-11β,17-dihydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione
382-66-1

9-fluoro-11β,17-dihydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium / Hydrogenation
2: bromine; acetic acid / Erhitzen des Reaktionsprodukts mit 2,4,6-Trimethyl-pyridin
3: aqueous methanol.K2CO3
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

9α-fluoro-11β-hydroxy-4-androstene-3,17-dione
357-09-5

9α-fluoro-11β-hydroxy-4-androstene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous methanol.K2CO3
2: NaBiO3
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

9α-fluorocortisone
79-60-7

9α-fluorocortisone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CrO3
2: aqueous methanol. K2CO3
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

9-fluoro-21-heptanoyloxy-11β,17-dihydroxy-pregn-4-ene-3,20-dione
599-22-4

9-fluoro-21-heptanoyloxy-11β,17-dihydroxy-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous methanol.K2CO3
View Scheme
fludrocortisone acetate
514-36-3

fludrocortisone acetate

succinic acid mono-(9-fluoro-11β,17-dihydroxy-3,20-dioxo-pregn-4-en-21-yl ester)
339-01-5

succinic acid mono-(9-fluoro-11β,17-dihydroxy-3,20-dioxo-pregn-4-en-21-yl ester)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous methanol.K2CO3
View Scheme

Fludrocortisone acetate Specification

The CAS register number of Fludrocortisone acetate is 514-36-3. It also can be called as [2-[(9S)-9-Fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate and the IUPAC name about this chemical is [2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate. The molecular formula about this chemical is C23H31FO6 and the molecular weight is 422.49. It belongs to the following product categories, such as Intermediates & Fine Chemicals; Pharmaceuticals; Steroids and so on. This chemical can be used as a mineralocorticoid. If you want to store this chemical, please keep it in a closed container and store it in a cool, dry, well ventilated warehouse, it should be away from fire and heat, it also should be separate from acid, food chemicals.

Physical properties about Fludrocortisone acetate are: (1)ACD/LogP: 2.32; (2)#H bond acceptors: 6; (3)#H bond donors: 2; (4)#Freely Rotating Bonds: 6; (5)Polar Surface Area: 78.9Å2; (6)Index of Refraction: 1.563; (7)Molar Refractivity: 105.3 cm3; (8)Molar Volume: 323.9 cm3; (9)Polarizability: 41.74x10-24cm3; (10)Surface Tension: 53.3 dyne/cm; (11)Enthalpy of Vaporization: 98.94 kJ/mol; (12)Boiling Point: 575.1 °C at 760 mmHg; (13)Vapour Pressure: 1.27E-15 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical has possible risk of harm to the unborn child. When you are using it, wear suitable protective clothing and do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OCC(=O)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]1(/C(=C\C(=O)CC1)CC[C@H]4[C@@H]2CC3)C)C)C
(2)InChI: InChI=1/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
(3)InChIKey: SYWHXTATXSMDSB-GSLJADNHBU
(4)Std. InChI: InChI=1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
(5)Std. InChIKey: SYWHXTATXSMDSB-GSLJADNHSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 240mg/kg (240mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
rat LD50 oral > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.

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