• Name

  Flupentiol

• EINECS 220-304-9
• CAS No. 2709-56-0
• Article Data4
• CAS DataBase
• Density 1.2118 (estimate)
• Solubility
• Melting Point
• Formula C₂₃H₂₅F₃N₂OS
• Boiling Point 554.7±50.0 °C(Predicted)
• Molecular Weight 434.526
• Flash Point 289.3oC
• Transport Information UN 2811 6.1/PG 3
• Appearance white or off-white solid
• Safety 36/37/39
• Risk Codes 20/21/22
• Molecular Structure
• Hazard Symbols Xn
• Synonyms 1-Piperazineethanol,4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]- (7CI,8CI);2-(Trifluoromethyl)-9-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propylidene]thiaxanthen;2-Trifluoromethyl-9-(3-[4-(2-hydroxyethyl)-1-piperazinyl]propylidene)thioxanthene;4-[3-[2-(Trifluoromethyl)thioxanthen-9-ylidene]propyl]-1-piperazineethanol;Fluanxol;Flupenthixol;Flupentixol;Fluxanxol;LC 44;N 7009;Siplaril;
• PSA 52.01000
• LogP 4.47750

Synthetic route

(Z)-flupentixol p-chlorobenzoate dihydrochloride

2709-56-0

cis-(Z)-flupenthixol

Conditions

Conditions	Yield
Stage #1: (Z)-flupentixol p-chlorobenzoate dihydrochloride With potassium hydroxide In methanol; water at 55℃; for 1h; Stage #2: In water; toluene at 70℃; Stage #3: With cyclohexane at 60℃;	70%

103-76-4

1-(2-hydroxyethyl)piperazine

28973-34-4

2-trifluoromethyl-9-(2-propenylidene)thioxanthene

A

2709-56-0

cis-(Z)-flupenthixol

B

53772-85-3

flupenthixol

Conditions

Conditions	Yield
Stage #1: 1-(2-hydroxyethyl)piperazine; 2-trifluoromethyl-9-(2-propenylidene)thioxanthene at 100℃; under 0.2 - 1 Torr; for 7h; Stage #2: In water; toluene at 70℃; for 0.25h; Stage #3: With sulfuric acid; ammonia more than 3 stages;

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112-13-0

n-decanoyl chloride

2709-56-0

cis-(Z)-flupenthixol

(Z)-flupentixol decanoate dihydrochloride

Conditions

Conditions	Yield
Stage #1: n-decanoyl chloride; cis-(Z)-flupenthixol In acetone for 1.5h; Heating / reflux; Stage #2: With hydrogenchloride In ethyl acetate at 5 - 25℃;	85%

122-01-0

4-chloro-benzoyl chloride

2709-56-0

cis-(Z)-flupenthixol

53772-85-3

flupenthixol

A

(Z)-flupentixol p-chlorobenzoate dihydrochloride

B

(E)-flupentixol p-chlorobenzoate hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-chloro-benzoyl chloride; cis-(Z)-flupenthixol; flupenthixol In ethyl acetate at 40 - 70℃; for 1h; Stage #2: With hydrogenchloride In water at 40℃; for 0.25h;	A 33% B n/a

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