Product Name

  • Name

    ASTROMICINSULFATE

  • EINECS
  • CAS No. 72275-67-3
  • Article Data2
  • CAS DataBase
  • Density 1.31 g/cm3
  • Solubility
  • Melting Point
  • Formula C17H35N5O6•2H2O4S
  • Boiling Point 621.1oC at760mmHg
  • Molecular Weight 503.574
  • Flash Point 329.4oC
  • Transport Information
  • Appearance
  • Safety Poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of SOx and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 72275-67-3 (ASTROMICINSULFATE)
  • Hazard Symbols
  • Synonyms ASTROMICINSULFATE;2-amino-N-[(1R,2R,3R,4R,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-(1-amin oethyl)oxan-2-yl]oxy-2,5-dihydroxy-6-methoxy-cyclohexyl]-N-methyl-acet amide: sulfuric acid;Abbott 44747;Fortimicin A disulfate;Fortimicin A sulfate;L-chiro-Inositol, 4-amino-1-[(aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-, sulfate (1:2) (salt)
  • PSA 192.54000
  • LogP -0.78420

Fortimicin a sulfate Chemical Properties

IUPAC Name: 2-Amino-N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylacetamide; sulfuric acid
Synonyms of Fortimicin a sulfate (CAS NO.72275-67-3) : 4-Amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol sulfate (1:2) (salt) Astromicin sulfate ; Fortimicin A sulfate ; L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-, disulfate ; L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methylsulfate (1:2) (salt)
CAS NO:72275-67-3
Molecular Formula:C17H39N5O14S2
Molecular Weight :601.6467
Molecular Structure :

Fortimicin a sulfate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular 750mg/kg (750mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Chemotherapy Vol. 29(Suppl,
dog LD50 intravenous 214mg/kg (214mg/kg)   Chemotherapy Vol. 29(Suppl,
guinea pig LD50 intramuscular 611mg/kg (611mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980.
mouse LD50 intramuscular 427mg/kg (427mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA		 Chemotherapy Vol. 29(Suppl,
mouse LD50 intraperitoneal 533mg/kg (533mg/kg)   Chemotherapy Vol. 29(Suppl,
mouse LD50 intravenous 94mg/kg (94mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980.
mouse LD50 oral 13600mg/kg (13600mg/kg)   Chemotherapy Vol. 29(Suppl,
mouse LD50 subcutaneous 546mg/kg (546mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 967, 1985.
rabbit LD50 intravenous 654mg/kg (654mg/kg)   Drugs in Japan Vol. -, Pg. 19, 1995.
rat LD50 intramuscular 1009mg/kg (1009mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980.
rat LD50 intraperitoneal 913mg/kg (913mg/kg)   Chemotherapy Vol. 29(Suppl,
rat LD50 intravenous 86mg/kg (86mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980.
rat LD50 oral > 10gm/kg (10000mg/kg)   Chemotherapy Vol. 29(Suppl,
rat LD50 subcutaneous 1364mg/kg (1364mg/kg)   Chemotherapy Vol. 29(Suppl,

Fortimicin a sulfate Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Mildly toxic by ingestion. An experimental teratogen. When Fortimicin a sulfate (CAS NO.72275-67-3) is heated to decomposition ,it emits very toxic fumes of SOx and NOx.

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