Product Name

  • Name

    Fotemustine

  • EINECS
  • CAS No. 92118-27-9
  • Density 1.37 g/cm3
  • Solubility
  • Melting Point 85°
  • Formula C9H19 Cl N3 O5 P
  • Boiling Point °Cat760mmHg
  • Molecular Weight 315.694
  • Flash Point °C
  • Transport Information
  • Appearance
  • Safety 36/37
  • Risk Codes 40
  • Molecular Structure Molecular Structure of 92118-27-9 (Fotemustine)
  • Hazard Symbols Xn
  • Synonyms Phosphonicacid, [1-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-, diethyl ester(9CI); Fotemustine; Muphoran; Mustophorane; S 10036
  • PSA 107.11000
  • LogP 2.92120

Fotemustine Chemical Properties

Molecular Structure of Fotemustine (CAS NO.92118-27-9):

IUPAC Name: 1-(2-Chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea 
Molecular Formula: C9H19ClN3O5P
Molecular Weight: 315.69
CAS Registry Number: 92118-27-9 
Index of Refraction: 1.524
Molar Refractivity: 70.32 cm3
Molar Volume: 229.7 cm3
Surface Tension: 49.4 dyne/cm
Density: 1.37 g/cm3
Classification Code: Antineoplastic agents; Drug / Therapeutic Agent; Mutation data 
Canonical SMILES: CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC
InChI: InChI=1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14)
InChIKey: YAKWPXVTIGTRJH-UHFFFAOYSA-N

Fotemustine Uses

 Fotemustine (CAS NO.92118-27-9) is used in the treatment of metastasising melanoma. A study has shown that Fotemustine produces over dacarbazine which improved response rates and increased survival in the treatment of disseminated cutaneous melanoma.

Fotemustine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 60mg/kg (60mg/kg)   Cancer Research. Vol. 47, Pg. 6782, 1987.
 

Fotemustine Specification

 Fotemustine (CAS NO.92118-27-9), its Synonyms are (+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate ; Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate ; Fotemustina ; Fotemustinum ; Phosphonic acid, (1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester . Fotemustine is a nitrosourea alkylating agent.

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