IUPAC Name: [ Ethyl 1-[2-(oxolan-2-ylmethoxy)ethyl]-4-phenylpiperidine-4-carboxylate
Synonyms of Furethidine (CAS NO.2385-81-1) : Ethyl 4-phenyl-1-(2-tetrahydrofurfuryloxyethyl)piperidine-4-carboxylate ; Furethidine ; Furethidinum ; Furetidina ; 1-(2-Tetrahydrofurfuryloxyethyl)-4-phenylpiperidine-4-carboxylic acid ethyl ester ; Isonipecotic acid, 4-phenyl-1-(2-((tetrahydrofurfuryl)oxy)ethyl)-, ethyl ester
InChI: InChI=1/C21H31NO4/c1-2-25-20(23)21(18-7-4-3-5-8-18)10-12-22(13-11-21)14-16-24-17-19-9-6-15-26-19/h3-5,7-8,19H,2,6,9-17H2,1H3
CAS NO:2385-81-1
Molecular Formula:C21H31NO4
Molecular Weight :361.4751
Molecular Structure :
EINECS: 219-195-0
Index of Refraction:1.519
Surface Tension: 40.2 dyne/cm
Density: 1.093 g/cm3
Flash Point: 238.2 °C
Enthalpy of Vaporization: 73.29 kJ/mol
Boiling Point: 470.3 °C at 760 mmHg
Vapour Pressure: 5.11E-09 mmHg at 25°C
Furethidine (CAS NO.2385-81-1) is a Class A/Schedule I drug which is controlled under UN drug conventions. It has similar effects to other opioid derivatives, such as analgesia, sedation, nausea and respiratory depression.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 15500ug/kg (15.5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Pharmacology and Chemotherapy. Vol. 15, Pg. 254, 1960. |
rat | LD50 | oral | 135mg/kg (135mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Pharmacology and Chemotherapy. Vol. 15, Pg. 254, 1960. |
rat | LD50 | subcutaneous | 26mg/kg (26mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Pharmacology and Chemotherapy. Vol. 15, Pg. 254, 1960. |
Poison by ingestion, subcutaneous, and intravenous routes. When Furethidine (CAS NO.2385-81-1) is heated to decomposition, it emits toxic fumes of NOx. Can be habit forming. This is a controlled substance (opiate) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.11 (1985). When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.
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