Galanthamine supplier | CasNO.357-70-0

Name
Galanthamine
EINECS 609-175-3
CAS No. 357-70-0
Article Data44
CAS DataBase
Density 1.28 g/cm³
Solubility
Melting Point 119-121 °C
Formula C₁₇H₂₁NO₃
Boiling Point 439.3 °C at 760 mmHg
Molecular Weight 287.359
Flash Point 219.5 °C
Transport Information
Appearance Off-white sSolid
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl- (7CI);Galanthamine (6CI,8CI);(-)-Galantamine;(-)-Galanthamine;6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, [4aS-(4aa,6b,8aR*)]-;BRN 0093736;Galantamin;Galantamina;Jilkon;Lycoremin;Lycoremine;NSC 100058;(+)Galanthamine;736-79-8;
PSA 41.93000
LogP 1.78820

Galanthamine Specification

The Galantamine is an organic compound with the formula C₁₇H₂₁NO₃. The systematic name of this chemical is galanthamine. With the CAS registry number 357-70-0, it is also named as 3,4-Dihydrogalanthamine. The product's categories are All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it is an off-white solid, which is used for the treatment of mild to moderate Alzheimer's disease and various memory impairments. Galantamine is indicated for mild to moderate Vascular Dementia and Alzheimer.

Physical properties about Galantamine are: (1)ACD/LogP: 1.75; (2)ACD/LogD (pH 5.5): -0.59; (3)ACD/LogD (pH 7.4): 1.12; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 2.94; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 49.83; (8)#H bond acceptors: 4; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 30.93 Å²; (12)Index of Refraction: 1.636; (13)Molar Refractivity: 80.31 cm³; (14)Molar Volume: 223.9 cm³; (15)Polarizability: 31.83×10^-24cm³; (16)Surface Tension: 56.6 dyne/cm; (17)Density: 1.28 g/cm³; (18)Flash Point: 219.5 °C; (19)Enthalpy of Vaporization: 73.39 kJ/mol; (20)Boiling Point: 439.3 °C at 760 mmHg; (21)Vapour Pressure: 1.71E-08 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O(c2c1O[C@H]4C[C@@H](O)/C=C\[C@@]43c1c(cc2)CN(C)CC3)C
(2)InChI: InChI=1/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
(3)InChIKey: ASUTZQLVASHGKV-JDFRZJQEBY
(4)Std. InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
(5)Std. InChIKey: ASUTZQLVASHGKV-JDFRZJQESA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)	Journal of Medicinal Chemistry. Vol. 37, Pg. 689, 1994.
mouse	LD50	subcutaneous	14mg/kg (14mg/kg)	United States Patent Document. Vol. #4550113,
rat	LD50	intraperitoneal	22900mg/kg (22900mg/kg)	United States Patent Document. Vol. #5177082,

Product Name

Galanthamine

Galanthamine Specification

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