Gliquidone supplier | CasNO.33342-05-1

Name
Gliquidone
EINECS 251-463-2
CAS No. 33342-05-1
Article Data73
CAS DataBase
Density 1.34 g/cm³
Solubility
Melting Point 179 °C
Formula C₂₇H₃₃N₃O₆S
Boiling Point
Molecular Weight 527.642
Flash Point
Transport Information
Appearance white powder
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms AR-DF 26;ARDF 26SE;Beglynor;Glurenorm;
PSA 130.26000
LogP 5.31900

Synthetic route

: 33456-68-7
4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonamid

: 3173-53-3
Cyclohexyl isocyanate

: 33342-05-1
gliquidone

Conditions

Conditions	Yield
Stage #1: 4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonamid With potassium carbonate at 40℃; for 0.5h; Stage #2: Cyclohexyl isocyanate at 90℃; for 4.5h; Reagent/catalyst; Temperature;	80%

: 33342-05-1
gliquidone

: N-Cyclohexyl-N',N''-bis-<4-<2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonyl>guanidin

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride Heating;	81%

: 33342-05-1
gliquidone

: 33456-68-7
4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonamid

Conditions

Conditions	Yield
With dmap; phthalic anhydride In pyridine for 5h; Reflux; Inert atmosphere;	77%
With pyridine; dmap; phthalic anhydride for 5h; Inert atmosphere; Reflux;	77%
With pyridine; dmap; phthalic anhydride for 4h; Inert atmosphere; Reflux;	75%

: 33342-05-1
gliquidone

: 108-24-7
acetic anhydride

: N-<4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonyl>acetamid

Conditions

Conditions	Yield
With pyridine for 0.25h;	71%

: 85-44-9
phthalic anhydride

: 33342-05-1
gliquidone

A: 33456-68-7
4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonamid

B: 2133-65-5
N-cyclohexylphthalimide

Conditions

Conditions	Yield
With pyridine; dmap for 4h; Heating;	A 46% B 46%

...Expand

: 33342-05-1
gliquidone

A: 33456-68-7
4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonamid

B: 2133-65-5
N-cyclohexylphthalimide

Conditions

Conditions	Yield
With pyridine; dmap; phthalic anhydride for 4h; Heating;	A 46% B 46%

: 108-30-5
succinic acid anhydride

: 33342-05-1
gliquidone

: N-<4-<2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl>benzolsulfonyl>succinimid

Conditions

Conditions	Yield
With pyridine; dmap	32%

: 33342-05-1
gliquidone

: nickel(II) chloride hexahydrate

: Ni(gliquidone)2Cl2

Conditions

Conditions	Yield
In methanol MeOH soln. of metal salt added to gliquidone soln. with stirring, warmedto ca. 60°C; filtered, washed, dried; elem. anal.;

: copper(II) choride dihydrate

: 33342-05-1
gliquidone

: Cu(gliquidone)2Cl2

Conditions

Conditions	Yield
In methanol MeOH soln. of metal salt added to gliquidone soln. with stirring, warmedto ca. 60°C; filtered, washed, dried; elem. anal.;

: iron(III) chloride hexahydrate

: 33342-05-1
gliquidone

: Fe(gliquidone)2Cl3

Conditions

Conditions	Yield
In methanol MeOH soln. of metal salt added to gliquidone soln. with stirring, warmedto ca. 60°C; filtered, washed, dried; elem. anal.;

: 33342-05-1
gliquidone

: chromium chloride hexahydrate

: Cr(gliquidone)2Cl2

Conditions

Conditions	Yield
In methanol MeOH soln. of metal salt added to gliquidone soln. with stirring, warmedto ca. 60°C; filtered, washed, dried; elem. anal.;

: 33342-05-1
gliquidone

: cadmium(II) chloride monohydrate

: Cd(gliquidone)2Cl2

Conditions

Conditions	Yield
In methanol MeOH soln. of metal salt added to gliquidone soln. with stirring, warmedto ca. 60°C; filtered, washed, dried; elem. anal.;

: 33342-05-1
gliquidone

: manganese(II) chloride monohydrate

: Mn(gliquidone)2Cl2

Conditions

Conditions	Yield
In methanol MeOH soln. of metal salt added to gliquidone soln. with stirring, warmedto ca. 60°C; filtered, washed, dried; elem. anal.;

: 33342-05-1
gliquidone

: cobalt(II) chloride hexahydrate

: Co(gliquidone)2Cl2

Conditions

Conditions	Yield
In methanol MeOH soln. of metal salt added to gliquidone soln. with stirring, warmedto ca. 60°C; filtered, washed, dried; elem. anal.;

: 33342-05-1
gliquidone

: 7646-85-7
zinc(II) chloride

: Zn(gliquidone)2Cl2

Conditions

Conditions	Yield
In methanol MeOH soln. of metal salt added to gliquidone soln. with stirring, warmedto ca. 60°C; filtered, washed, dried; elem. anal.;

: 33342-05-1
gliquidone

: 84957-29-9, 97164-55-1, 130431-30-0
cefpirome

: C22H22N6O5S2*C27H33N3O6S

Conditions

Conditions	Yield
In methanol Reflux;

: 110-85-0
piperazine

: 33342-05-1
gliquidone

: 78-83-1
2-methyl-propan-1-ol

: 2C27H33N3O6S*C4H10N2*2C4H10O

Conditions

Conditions	Yield
at 20 - 50℃; for 13h;

...Expand

: 110-85-0
piperazine

: 33342-05-1
gliquidone

: 64-17-5
ethanol

: 2C27H33N3O6S*C4H10N2*2C2H6O

Conditions

Conditions	Yield
at 20 - 50℃; for 13h;

...Expand

: 110-85-0
piperazine

: 33342-05-1
gliquidone

: 75-05-8
acetonitrile

: 2C27H33N3O6S*C4H10N2*C2H3N

Conditions

Conditions	Yield
at 20 - 50℃; for 13h;

...Expand

: 110-85-0
piperazine

: 33342-05-1
gliquidone

: 67-63-0
isopropyl alcohol

: 2C27H33N3O6S*C4H10N2*2C3H8O

Conditions

Conditions	Yield
at 20 - 50℃; for 13h;

...Expand

: 110-85-0
piperazine

: 67-56-1
methanol

: 33342-05-1
gliquidone

: 2C27H33N3O6S*C4H10N2*2CH4O

Conditions

Conditions	Yield
at 20 - 50℃; for 13h;

...Expand

: 33342-05-1
gliquidone

: 657-24-9
dimethylbiguanide

: C4H12N5(1+)*C27H32N3O6S(1-)

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 24h; Solvent; Temperature; Sonication;

Gliquidone Specification

The Gliquidone, with the CAS registry number 33342-05-1 and EINECS registry number 251-463-2, has the IUPAC name of 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea. It belongs to the product categories of Active Pharmaceutical Ingredients and API. And the molecular formula of the chemical is C₂₇H₃₃N₃O₆S. What's more, it is an anti-diabetic drug in the sulfonylurea class, and always used in the treatment of diabetes mellitus type 2.

The physical properties of Gliquidone are as followings: (1)ACD/LogP: 3.11; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 1.94; (4)ACD/LogD (pH 7.4): 1.14; (5)ACD/BCF (pH 5.5): 9.23; (6)ACD/BCF (pH 7.4): 1.47; (7)ACD/KOC (pH 5.5): 79.48; (8)ACD/KOC (pH 7.4): 12.62; (9)#H bond acceptors: 9; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 112.68 Å²; (13)Index of Refraction: 1.624; (14)Molar Refractivity: 138.9 cm³; (15)Molar Volume: 393.2 cm³; (16)Polarizability: 55.06×10^-24cm³; (17)Surface Tension: 62.7 dyne/cm; (18)Density: 1.34 g/cm³.

Uses of Gliquidone: It can react with acetic acid anhydride to produce N-{4-[2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl]benzolsulfonyl}acetamid. This reaction will need reagent pyridine. The reaction time is 15 minutes, and the yield is about 71%.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(NC1CCCCC1)NS(=O)(=O)c2ccc(cc2)CCN4C(=O)c3c(ccc(OC)c3)C(C4=O)(C)C
(2)InChI: InChI=1/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33)
(3)InChIKey: LLJFMFZYVVLQKT-UHFFFAOYAT

Product Name

Gliquidone

Synthetic route

Gliquidone Specification

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