Product Name

  • Name

    Granisetron hydrochloride

  • EINECS 634-603-0
  • CAS No. 107007-99-8
  • Article Data3
  • CAS DataBase
  • Density 1.33g/cm3
  • Solubility
  • Melting Point 290-292 °C
  • Formula C18H25ClN4O
  • Boiling Point 532 °C at 760 mmHg
  • Molecular Weight 348.876
  • Flash Point 275.6 °C
  • Transport Information
  • Appearance white to off-white crystalline solid
  • Safety 26-36-37
  • Risk Codes 22-62-37/38-36/37/38-36
  • Molecular Structure Molecular Structure of 107007-99-8 (Granisetron hydrochloride)
  • Hazard Symbols HarmfulXn,IrritantXi
  • Synonyms 1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, monohydrochloride(9CI);BRL 43694A;Kytril;1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride(1:1);1H-Indazole-3-carboxamide,1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, monohydrochloride, endo-;
  • PSA 50.16000
  • LogP 3.44920

Synthetic route

granisetron
109889-09-0, 124998-65-8

granisetron

granisetron hydrochloride
107007-99-8

granisetron hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol77%
With hydrogenchloride In water; toluene at 50 - 60℃;
endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
76272-41-8, 141650-55-7, 76272-56-5

endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine

1-methylindazole-3-carboxylic acid chloride
106649-02-9

1-methylindazole-3-carboxylic acid chloride

granisetron hydrochloride
107007-99-8

granisetron hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; triethylamine In dichloromethane
granisetron hydrochloride
107007-99-8

granisetron hydrochloride

granisetron
109889-09-0, 124998-65-8

granisetron

Conditions
ConditionsYield
With ammonia; water for 0.5h; Product distribution / selectivity;

Granisetron hydrochloride Chemical Properties


IUPAC Name: 1-Methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide hydrochloride 
Empirical Formula: C18H25ClN4O
Molecular Weight: 348.8703 
Flash Point: 275.6 °C
Enthalpy of Vaporization: 80.77 kJ/mol
Boiling Point: 532 °C at 760 mmHg
Vapour Pressure: 2.12E-11 mmHg at 25 °C 
Appearance: White to Off-White Crystalline Solid
Melting Point: 290-292 °C
storage temp.: Room temp
Classification Code of Granisetron hydrochloride (CAS NO.107007-99-8): Anti-emetic; Drug / Therapeutic Agent; Mutation data; Reproductive Effect
Product Categories: Pharmaceutical material and intermeidates; Active Pharmaceutical Ingredients; API; Heterocyclic Compounds; Intermediates & Fine Chemicals; Neurochemicals; Pharmaceuticals; Granisetron; Serotonin receptor; Serotonin

Granisetron hydrochloride Uses

 Granisetron hydrochloride (CAS NO.107007-99-8) is used as an antiemetic.

Granisetron hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3mg/kg (3mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING		 Yakkyoku. Pharmacy. Vol. 43, Pg. 589, 1992.
dog LDLo oral 15mg/kg (15mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 2697, 1995.
mouse LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990.
mouse LD50 oral 350mg/kg (350mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
rat LD50 intravenous 14mg/kg (14mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990.
rat LD50 oral 350mg/kg (350mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.

Granisetron hydrochloride Safety Profile

Hazard Codes: HarmfulXn,IrritantXi
Risk Statements: 22-62-37/38-36/37/38-36 
R22:Harmful if swallowed. 
R62:Risk of impaired fertility. 
R37/38:Irritating to respiratory system and skin. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R36:Irritating to eyes.
Safety Statements: 26-36-37 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S37:Wear suitable gloves.
RTECS: NK7882200

Granisetron hydrochloride Specification

  Granisetron hydrochloride (CAS NO.107007-99-8), its Synonyms are 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide monohydrochloride ; Granisetron HCl ; Granisetron hydrochloride preservative free ; Kytril ; Kytril Injection ; endo-1-Methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide hydrochloride .

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