HALOPROGIN (200 MG)

EPA Genetic Toxicology Program.

The IUPAC name of Haloprogin is 1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene . With the CAS registry number 777-11-7, it is also named as (3-Iod-2-propinyl)-(2,4,5-trichlorphenyl)ether ; 2,4,5-Trichlorophenyl gamma-iodopropargil ether ; 2,4,5-Trichlorophenyl iodopropargyl ether ; 2,4,5-Trichlorophenyl-gamma-iodopropargyl ether ; 3-Iodo-2-propynyl 2,4,5-trichlorophenyl ether ; Benzene, 1,2,4-trichloro-5-((3-iodo-2-propynyl)oxy)- ; Haloprogina ; Haloprogine ; Halotex . The trade names of Haloprogin in the market are Halotex, Mycanden, Mycilan, and Polik. 

The Haloprogin is light yellow or white crystal with special odor. It can be soluble in ether , chloroform , ethyl acetate , methanol , ethanol , and hot glacial acetic acid , and almost insoluble in water. As an antifungal drug, Haloprogin can be used to treat athlete's foot and other fungal infections. It was marketed over the counter primarily to treat tinea infections of the skin, and was previously used in 1% topical creams as an antifungal agent. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects.

When heated to decomposition Haloprogin emits very toxic Cl⁻ and I⁻. It is harmful if swallowed and is irritative to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

The Haloprogin can be obtained by the propargyl bromide (C₃H₃Br) and 2,4,5-trichlorophenol . First, using the raw materials to get 2,4,5 - trichloro-phenyl-γ-propargyl ether by condensation, and then we obtain the product after iodization.

The other characteristics of this product can be summarized as: (1)#H bond acceptors: 1 ; (2)#H bond donors: 0 ; (3)#Freely Rotating Bonds: 2 ; (4)Index of Refraction: 1.657 ; (5)Molar Refractivity: 67.85 cm³ ; (6)Molar Volume: 184.4 cm³ ; (7)Polarizability: 26.9×10^-24 cm³ ; (8)Surface Tension: 55.4 dyne/cm ; (9)Enthalpy of Vaporization: 61.65 kJ/mol ; (10)Vapour Pressure: 5.38E-06 mmHg at 25°C. People can use the following data to convert to the molecule structure. SMILES: Clc1cc(OCC#CI)c(Cl)cc1Cl; InChI: InChI=1/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2.

The following is the toxicity data which has been texted.