NOTE: The EPA has canceled registration of pesticides containing heptachlor with the exception of its use for termite control by subsurface ground insertion external to the dwelling.
CAS: 76-44-8
EINECS: 200-962-3
Product Categories: 2000/60/ECMore...Close... ; Alpha sort ; Baby Food Directives 13/2003 EC&14/2003 ECPesticides ; CyclodienesPesticides&Metabolites ; European Community: ISO and DIN;H;HA -HTMethod Specific ; H-MAlphabetic;Insecticides ; Method Specific ; Oeko-Tex Standard 100 ; PesticidesMethod Specific ; ASTM 4947: Analysis of Chlordane and Heptachlor in AirPesticides ; ASTM Air Monitoring ; 2000/60/EC ; Pesticides .
Following is the Molecular Structure of Heptachlor (76-44-8):
SMILES: ClC1/C=C\C2C3(Cl)C(\Cl)=C(\Cl)C(Cl)(C12)C3(Cl)Cl
InChI: InChI=1/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H
InChIKey: FRCCEHPWNOQAEU-UHFFFAOYAM
Std.InChI: InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H
Std.InChIKey: FRCCEHPWNOQAEU-UHFFFAOYSA-N
Molecular Formula: C10H5Cl7
Molecular Weight: 373.32
Melting Point:
Boiling Point: 392.3℃ at 760mmHg
Flash Point: 192.9℃
Molar Volume: 207.7cm3
Density: 1.79g/cm3
Index of Refraction: 1.645
Molar Refractivity: 75.37cm3
Surface Tension: 54.7dyne/cm
Polarizability: 29.88 10-24cm3
Enthalpy of Vaporization: 61.7kJ/mol
Vapour Pressure: 5.23E-06mmHg at 25℃
Heptachlor (76-44-8) can be used as a insecticide.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LCLo | inhalation | 150mg/m3/4H (150mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 71, 1982. | |
cat | LDLo | oral | 50mg/kg (50mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: AGGRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. |
guinea pig | LD50 | oral | 116mg/kg (116mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 576, 1966. | |
guinea pig | LDLo | skin | 1gm/kg (1000mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: AGGRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. |
hamster | LD50 | oral | 100mg/kg (100mg/kg) | European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974. | |
mammal (species unspecified) | LCLo | inhalation | 200mg/m3/4H (200mg/m3) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: AGGRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. |
mammal (species unspecified) | LD50 | unreported | 60mg/kg (60mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 59, 1971. | |
mouse | LD50 | intracrebral | 12mg/kg (12mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Toxicology Letters. Vol. 60, Pg. 289, 1992. |
mouse | LD50 | intraperitoneal | 130mg/kg (130mg/kg) | Soviet Genetics. English translation of GNKAA5. Vol. 2, Pg. 80, 1966. | |
mouse | LD50 | oral | 68mg/kg (68mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 12, 1978. | |
mouse | LDLo | intravenous | 20mg/kg (20mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 107, Pg. 266, 1953. | |
rabbit | LD50 | skin | 500mg/kg (500mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958. | |
rat | LD50 | intraperitoneal | 27mg/kg (27mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Food and Cosmetics Toxicology. Vol. 11, Pg. 63, 1973. |
rat | LD50 | oral | 40mg/kg (40mg/kg) | Pharmaceutical Journal. Vol. 185, Pg. 361, 1960. | |
rat | LD50 | skin | 119mg/kg (119mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 12, 1978. |
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man.7,1987,p.146.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man.20,1979,p.129.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210);Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man.5,1974,p.173.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A.,49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 , 1979,p. 129.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed) Clear Evidence: mouse NCITR*National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-9 ,1977. ; Results negative: rat NCITR*National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-9 ,1977. . EPA Genetic Toxicology Program. Community Right-To-Know List.
Hazard Codes: T Toxic, N Dangerous for the environment, F Flammable, Xn Harmful.
Risk Statements: 24/25-33-40-50/53-39/23/24/25-23/24/25-11-67-65-38
R24/25: Toxic in contact with skin and if swallowed.
R33: Danger of cumulative effects.
R40: Limited evidence of a carcinogenic effect.
R50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R11: Highly Flammable.
R67: Vapors may cause drowsiness and dizziness.
R65: Harmful: May cause lung damage if swallowed.
R38: Irritating to the skin.
Safety Statements: 36/37-45-60-61-62-16-7
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
S60: This material and/or its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions safety data sheet.
S62: If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
S16: Keep away from sources of ignition-No smoking.
S7: Keep container tightly closed.
RIDADR: 2761
RTECS: PC0700000
HazardClass: 6.1(a)
PackingGroup: II
Confirmed carcinogen with experimental carcinogenic data. A poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Human mutation data reported. Acute exposure and chronic doses have caused liver damage. See also closely related chlordane. In humans, a dose of 1-3 g can cause serious symptoms, especially where liver impairment is the case. Acute symptoms include tremors, convulsions, kidney damage, respiratory collapse, and death.
OSHA PEL: TWA 0.5 mg/m3 (skin)
ACGIH TLV: 0.05 mg/m3 (skin); Animal Carcinogen
DFG MAK: 0.5 mg/m3, Confirmed Animal Carcinogen with Unknown Relevance to Humans.
Heptachlor (76-44-8) also called for Velsicol 104(r) ; E3314 ; E3314(r) ; Drinox(r) ; Cupincida ; Fennotox;(-)-heptachlor ; (+)-Heptachlor . Heptachlor (76-44-8) is a white to light tan waxy looking solid.It's noncombustible and insoluble in waterWhen heated to decomposition it emits toxic fumes of Cl−.It should be stored at 4℃.Be attention of this chemical is highly toxic.
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