Hexarelin

1. Introduction of Hexarelin
Hexarelin is one kind of white powder. The IUPAC name of Hexarelin is 6-amino-2-[[2-[[2-[2-[[2-[[2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoylamino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide. Hexarelin belongs to belongs to Peptide;Glucagon receptor and related;Peptides. In addition, Hexarelin is a synthetic growth hormone releasing peptide; structurally similar to GHRP-6, with the substitution of D-Trp with its 2-methyl derivative; more potent & stable and less toxic than GHRP-6. Besides, it can soluble in water or 1% acetic acid.

2. Properties of Hexarelin
Physical properties about Hexarelin are:
(1)ACD/LogP: 1.97; (2)# of Rule of 5 Violations: 3; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 18; (8)#H bond donors: 14; (9)#Freely Rotating Bonds: 25; (10)Polar Surface Area: 156.02 Å²; (11)Index of Refraction: 1.66; (12)Molar Refractivity: 247.69 cm³; (13)Molar Volume: 670.7 cm³; (14)Polarizability: 98.19×10^-24cm³; (15)Surface Tension: 66.5 dyne/cm; (16)Density: 1.322 g/cm³; (17)Flash Point: 802.7 °C; (18)Enthalpy of Vaporization: 214.68 kJ/mol; (19)Boiling Point: 1403.6 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

3. Structure Descriptors of Hexarelin
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(N)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](N)Cc1cncn1)Cc3c2ccccc2nc3C)C)Cc5c4ccccc4nc5)Cc6ccccc6)CCCCN
(2)InChI: InChI=1/C47H58N12O6/c1-27-34(33-15-7-9-17-37(33)54-27)23-41(58-44(62)35(49)22-31-25-51-26-53-31)45(63)55-28(2)43(61)57-40(21-30-24-52-36-16-8-6-14-32(30)36)47(65)59-39(20-29-12-4-3-5-13-29)46(64)56-38(42(50)60)18-10-11-19-48/h3-9,12-17,24-26,28,35,38-41,52,54H,10-11,18-23,48-49H2,1-2H3,(H2,50,60)(H,51,53)(H,55,63)(H,56,64)(H,57,61)(H,58,62)(H,59,65)/t28-,35-,38-,39+,40-,41+/m0/s1
(3)InChIKey: RVWNMGKSNGWLOL-GIIHNPQRBK

4. Uses of Hexarelin
Hexarelin is used for curing the lack of somatotropic hormone. Hexarelin is a six-amino acid peptide. Studies have shown that hexarelin is actually more effective and longer lasting than growth hormone releasing hormone (GHRH). It is also known that GHRP-6 has a synergistic effect with GHRH, causing a far greater release than either of these substances alone. By combining GHRP-6 with Hexarelin, a more potent GH releasing peptide combination is created than ever heard of. The potential clinical usefulness of these GH releasing hexapeptides is also reinforced by observations that long-term administration produces elevations in circulating IGF-1 concentrations. Long term treatment with GHRP-6 similarly has been shown to elevate serum IGF-1 as well as IGF-binding protein-3 concentrations and promote linear growth.