-
Name
hydrastinine
- EINECS
- CAS No. 6592-85-4
- Density 1.332g/cm3
- Solubility
- Melting Point 117°
- Formula C11H13NO3
- Boiling Point 342.5°Cat760mmHg
- Molecular Weight 207.229
- Flash Point 161°C
- Transport Information
- Appearance
- Safety Poison by subcutaneous route. Can cause paralysis of vasomotor nerves and vagus endings. When heated to decomposition it emits highly toxic fumes of NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms 5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol;hydrastinine;1,3-Dioxolo(4,5-g)isoquinolin-5-ol,5,6,7,8-tetrahyro-6-methyl;1-hydroxy-6,7-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline;EINECS 229-533-9;6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ol;1,3-Dioxolo[4,5-g]isoquinolin-5-ol,5,6,7,8-tetrahydro-6-methyl;1,3-Dioxolo[4,5-g]isoquinolin-5-ol, 5,6,7,8-tetrahydro-6-methyl-;Hydraztinine;
- PSA 41.93000
- LogP 0.83200
Hydrastinine Chemical Properties
IUPAC Name: 6-Methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
Synonyms of Hydrastinine (CAS NO.6592-85-4) : 1,3-Dioxolo[4,5-g]isoquinolin-5-ol, 5,6,7,8-tetrahydro-6-methyl- ; 1-Hydroxy-6,7-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline ; 5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-ol (9CI) ; 5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol ; 6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-ol
CAS NO:6592-85-4
Molecular Formula:C11H13NO3
Molecular Weight :207.2258
Molecular Structure :
EINECS: 229-533-9
Index of Refraction: 1.617
Surface Tension: 54 dyne/cm
Density: 1.332 g/cm3
Flash Point: 161 °C
Enthalpy of Vaporization: 61.88 kJ/mol
Boiling Point: 342.5 °C at 760 mmHg
Vapour Pressure: 2.87E-05 mmHg at 25°C
Hydrastinine Uses
Hydrastinine (CAS NO.6592-85-4) was patented by Bayer as a haemostatic drug during 1910s.
Hydrastinine Production
Hydrastinine (CAS NO.6592-85-4) was produced by oxidative splitting of hydrastine hydrochloride with nitric acid in good yield.
Hydrastinine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rabbit | LDLo | subcutaneous | 300mg/kg (300mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| rat | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. |
Hydrastinine Safety Profile
Poison by subcutaneous route. Can cause paralysis of vasomotor nerves and vagus endings. When heated to decomposition it emits highly toxic fumes of NOx.
RIDADR 1544
HazardClass 6.1(b)
PackingGroup III
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