-
Name
1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine)
- EINECS 200-693-1
- CAS No. 68-88-2
- Article Data4
- CAS DataBase
- Density 1.1020 (rough estimate)
- Solubility < 700 mg/mL
- Melting Point 190 ºC
- Formula C21H27 Cl N2 O2
- Boiling Point 250 °C(Press: 0.1 Torr)
- Molecular Weight 374.911
- Flash Point
- Transport Information
- Appearance Yellow Oil
- Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
- Risk Codes R11; R20/22; R35
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Molecular Structure
- Hazard Symbols
- Synonyms Ethanol,2-[2-[4-(4-chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]- (6CI); Ethanol, 2-[2-[4-(p-chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]-(8CI); (?à)-Hydroxyzine; 1-(p-Chloro-a-phenylbenzyl)-4-[2-((2-hydroxyethoxy)ethyl)]piperazine;1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine;1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine;1-(p-Chlorodiphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine;2-[2-[4-(p-Chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol; Hydroxizine; Hydroxyzin;Hydroxyzine; Hydroxyzyne; NSC 169188; Tran-Q; Tranquizine; U.C.B 4492
- PSA 35.94000
- LogP 2.93170
Hydroxyzine Chemical Properties
Chemical Name: 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine)
IUPAC NAME: 2-[2-[4-[(4-Chlorophenyl)-phenylmethyl]piperazin-1-
yl]ethoxy]ethanol
CAS No.: 68-88-2
EINECS: 200-693-1
RTECS: KK2275000
RTECS Class: Drug ; Reproductive Effector
Molecular Formula: C21H27ClN2O2
Molecular Weight: 374.90 g/mol
Melting Point: 190°C
Density: 1.182 g/cm3
Flash Point: 255.7 °C
Boiling Point: 499.2 °C at 760 mmHg
Following is the structure of 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine) (68-88-2):
Product Categories about 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine) (68-88-2) are Intermediates & Fine Chemicals ; Pharmaceuticals
The chemical synonymous of 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine) (68-88-2) are 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-((2-hydroxyethoxy)ethyl)piperazine ; 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine ; 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine ; 1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine ; 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol ; 2-(2-(4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl)ethoxy)ethanol ; Atara ; Atarax
Hydroxyzine Toxicity Data With Reference
| 1. | orl-rat LD50:840 mg/kg | CHTPBA Chimica Therapeutica. 3 (1968),210. | ||
| 2. | ipr-rat LD50:160 mg/kg | CHTPBA Chimica Therapeutica. 3 (1968),210. | ||
| 3. | ivn-rat LD50:45 mg/kg | ANPBAZ Acta Neurologia et Psychiatrica Belgica. 61 (1961),669. | ||
| 4. | orl-mus LD50:480 mg/kg AANEAB 7,87,63 | |||
| 5. | ipr-mus LD50:81,300 µg/kg | DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. 23 (1971),281. | ||
| 6. | ivn-mus LD50:137 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,237. |
Hydroxyzine Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Attentions:
1. Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
2. Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
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