INOSINIC ACID supplier | CasNO.131-99-7

Name
IMP
EINECS 205-045-1
CAS No. 131-99-7
Article Data54
CAS DataBase
Density 2.319 g/cm³
Solubility
Melting Point
Formula C₁₀H₁₃N₄O₈P
Boiling Point 851.369 °C at 760 mmHg
Molecular Weight 348.209
Flash Point 468.691 °C
Transport Information
Appearance
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 5'-IMP;IMP;Inosine 5'-(dihydrogen phosphate);Inosine 5'-monophosphate;Inosine5'-phosphate;Inosine-5'-monophosphoric acid;Inosinic acid;
PSA 189.83000
LogP -2.15190

Synthetic route

: 78681-84-2
Phosphoric acid (3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester bis-(2,2,2-tribromo-ethyl) ester

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With Nafion 125; lithium perchlorate In N,N-dimethyl-formamide; acetonitrile electrolysis;	89%

: 61-19-8
5'-adenosine monophosphate

A: 131-99-7
5'-inosine monophosphate

B: 58-64-0
adenosine 5'-diphosphate

C: 56-65-5
ATP

Conditions

Conditions	Yield
With zinc(II) chloride In methanol at 25℃; Product distribution; biosynthesis; various typ-, and conc. of reagent;
In methanol at 25℃; biosynthesis by Candida boidnii No. 2201; pH = 6.5;	A 14.8 mmol B 36.8 mmol C 24.0 mmol
With zinc(II) chloride In methanol at 25℃; biosynthesis by Candida boidnii No. 2201; pH = 6.5;	A 2.0 mmol B n/a C 36.8 mmol
In methanol at 25℃; biosynthesis by Candida boidnii No. 2201; pH = 6.5;	A 14.8 mmol B 1.1 mmol C 24.0 mmol

...Expand

: 58-63-9
Inosine

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With triethyl phosphate; trichlorophosphate In water at 0℃; for 2h; Rate constant; Product distribution; var. reaction conditions;	91 % Chromat.
With potassium dihydrogenphosphate; D-glucose; guanosine-inosine kinase from Exiguobacterium acetylicum In various solvent(s) at 32℃; pH=7.2; Enzymatic reaction;
With DL-dithiothreitol; recombinant cytosolic 5'-nucleotidase II; ATP In various solvent(s) at 37℃; pH=7.4; Enzyme kinetics; Further Variations:; Reagents;
With sodium pyrophosphate; sodium acetate buffer; Escherichia blattae wild type phosphotransferase at 30℃; pH=5.0; Enzyme kinetics; Further Variations:; Reagents;
With trimethyl phosphite; trichlorophosphate at 0℃;

: 97-55-2, 7540-64-9, 99945-37-6, 130384-52-0
5-phosphoribosyl-1-pyrophosphate

: 68-94-0
hypoxanthine

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With Toxoplasma gondii phosphoribosyltransferase In alkaline aq. solution at 37℃; pH=7.4; Enzyme kinetics;

: 58-63-9
Inosine

A: 572-47-4
3'-inosine monophosphate

B: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With disodium pyrophoshate; Shigella flexneri acid phosphatase In various solvent(s) at 30℃; pH=5.0; Enzyme kinetics; Further Variations:; Reagents;

: 68-94-0
hypoxanthine

: 5-phospho-α-D-ribosyl 1-pyrophosphate

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With hypoxanthine phosphoribosyltransferase Enzyme kinetics; Further Variations:; Reagents;

: 4229-50-9
N6-methyl AMP

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With diothiothreitol; water at 37℃; pH=6.8; Enzyme kinetics;

5'-CTCCTTCCATACGGTGCACCTTCCTC-3': 5'-CTCCTTCCATACGGTGCACCTTCCTC-3'

5'-Cy5-ATACGCTTATCGGTACATGAGCACTGCAGCACTGGACCAC-Iowa black RQ-3'/5'-CATGTACCGATAAGCGTATTATGGAAGGAGGCGTTATGAGGGGTCCA-3'/5'-ACCTGGGGGAGTATTGCGGAGGAAGGTGCGTGGTCCAGTGCTGCAGTG-3'/bis(adenosine 5'-monophosphate) complex: 5'-Cy5-ATACGCTTATCGGTACATGAGCACTGCAGCACTGGACCAC-Iowa black RQ-3'/5'-CATGTACCGATAAGCGTATTATGGAAGGAGGCGTTATGAGGGGTCCA-3'/5'-ACCTGGGGGAGTATTGCGGAGGAAGGTGCGTGGTCCAGTGCTGCAGTG-3'/bis(adenosine 5'-monophosphate) complex

A 5'-Cy5-ATACGCTTATCGGTACATGAGCACTGCAGCACTGGACCAC-Iowa black RQ-3'/5'-CATGTACCGATAAGCGTATTATGGAAGGAGGCGTTATGAGGGGTCCA-3'/5'-ACCTGGGGGAGTATTGCGGAGGAAGGTGCGTGGTCCAGTGCTGCAGTG-3'/5'-CTCCTTCCATACGGTGCACCTTCCTC-3': 5'-Cy5-ATACGCTTATCGGTACATGAGCACTGCAGCACTGGACCAC-Iowa black RQ-3'/5'-CATGTACCGATAAGCGTATTATGGAAGGAGGCGTTATGAGGGGTCCA-3'/5'-ACCTGGGGGAGTATTGCGGAGGAAGGTGCGTGGTCCAGTGCTGCAGTG-3'/5'-CTCCTTCCATACGGTGCACCTTCCTC-3'

B: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid sodium salt; sodium chloride; adenosine deaminase In water at 25 - 70℃; for 1.33333h; pH=7.4; Enzymatic reaction;

...Expand

5'-Cy5-ATACGCTTATCGGTACATGAGCACTGCAGCACTGGACCAC-Iowa black RQ-3'/5'-AGGTGCACGTGGTCCAGTGCTGCAGTG-3'/5'-ACCTGGGGGAGTATTGCGGAGGAAGGTGCGTGGTCCAGTGCTGCAGTG-3'/adenosine 5'-monophosphate complex: 5'-Cy5-ATACGCTTATCGGTACATGAGCACTGCAGCACTGGACCAC-Iowa black RQ-3'/5'-AGGTGCACGTGGTCCAGTGCTGCAGTG-3'/5'-ACCTGGGGGAGTATTGCGGAGGAAGGTGCGTGGTCCAGTGCTGCAGTG-3'/adenosine 5'-monophosphate complex

A 5'-Cy5-ATACGCTTATCGGTACATGAGCACTGCAGCACTGGACCAC-Iowa black RQ-3'/5'-AGGTGCACGTGGTCCAGTGCTGCAGTG-3'/5'-ACCTGGGGGAGTATTGCGGAGGAAGGTGCGTGGTCCAGTGCTGCAGTG-3'/5'-CTCCTTCCATACGGTGCACCTTCCTC-3': 5'-Cy5-ATACGCTTATCGGTACATGAGCACTGCAGCACTGGACCAC-Iowa black RQ-3'/5'-AGGTGCACGTGGTCCAGTGCTGCAGTG-3'/5'-ACCTGGGGGAGTATTGCGGAGGAAGGTGCGTGGTCCAGTGCTGCAGTG-3'/5'-CTCCTTCCATACGGTGCACCTTCCTC-3'

B: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With adenosine deaminase aq. buffer; Enzymatic reaction;

: C24H24N6O9PPol

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
Stage #1: C24H24N6O9PPol With ammonium hydroxide In water at 55℃; for 15h; solid phase reaction; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 0.333333h; solid phase reaction;

: C28H42N4O9PPolSi2

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 0.333333h; solid phase reaction;

: 95188-97-9
C6H15O13P3

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With Leishmania donovani adenine phosphoribosyltransferase; sodium fluoride; magnesium chloride for 1h; pH=7.4; Kinetics; aq. buffer; Enzymatic reaction;

: 61-19-8
5'-adenosine monophosphate

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With Dr0824 from Deinococcus radiodurans R1; water at 30℃; for 16h; pH=7.5; Reagent/catalyst; Enzymatic reaction;

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 97-55-2, 7540-64-9, 99945-37-6, 130384-52-0
5-phosphoribosyl-1-pyrophosphate

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With mycobacterium tuberculosis hypoxanthine–guanine phosphoribosyltransferase In aq. buffer at 25℃; Kinetics; Enzymatic reaction;
With recombinant Thermus thermophilus HB8 xanthine phosphoribosyltransferase; magnesium chloride In aq. buffer at 70℃; for 0.166667h; pH=6; Catalytic behavior; Enzymatic reaction;

: pentasodium 5-phosphoribosyl-α-1-pyrophosphate

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 131-99-7
5'-inosine monophosphate

Conditions

Conditions	Yield
With recombinant Thermus thermophilus HB27 hypoxanthine phosphoribosyltransferase; magnesium chloride In aq. buffer at 70℃; for 0.0333333h; pH=8; Catalytic behavior; Kinetics; Concentration; Reagent/catalyst; Temperature; Enzymatic reaction;

: 1984-15-2
Methylenediphosphonic acid

: 131-99-7
5'-inosine monophosphate

: C11H17N4O13P3

Conditions

Conditions	Yield
With 1,1'-carbonyldiimidazole Condensation;	74%

: 2466-76-4
N-Acetylimidazole

: 131-99-7
5'-inosine monophosphate

: 2′,3′-di-O-acetyl β-inosine-5′-phosphate

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 4h; pH=8;	71%

: 131-99-7
5'-inosine monophosphate

: 120138-93-4
C10H14N4O10P2

Conditions

Conditions	Yield
With sodium hypophosphate at 60℃; pH 6;	66%

: 110-91-8
morpholine

: 131-99-7
5'-inosine monophosphate

: inosine 5'-phosphoromorpholidate sodium salt

Conditions

Conditions	Yield
With 2,2'-dipyridyldisulphide; triphenylphosphine; sodium iodide In dimethyl sulfoxide for 0.666667h; Ambient temperature;

: 288-32-4
1H-imidazole

: 131-99-7
5'-inosine monophosphate

: 66536-80-9
inosine-5'-phosphorimidazolide

Conditions

Conditions	Yield
With 2,2'-dipyridyldisulphide; triphenylphosphine

: 288-32-4
1H-imidazole

: 131-99-7
5'-inosine monophosphate

: inosine 5'-phosphoroimidazolidate sodium salt

Conditions

Conditions	Yield
With 2,2'-dipyridyldisulphide; triphenylphosphine; sodium iodide In dimethyl sulfoxide for 0.666667h; Ambient temperature;

: 67-56-1
methanol

: 131-99-7
5'-inosine monophosphate

: methyl inosine 5'-monophosphate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide Ambient temperature;

: 131-99-7
5'-inosine monophosphate

: 58-63-9
Inosine

Conditions

Conditions	Yield
With sodium acetate buffer; Escherichia blattae wild type 5'-nucleotidase at 30℃; pH=4.0; Enzyme kinetics; Further Variations:; Reagents;
With disodium pyrophoshate; Shigella flexneri acid phosphatase In various solvent(s) pH=6.0; Enzyme kinetics;
With Acinetobacter baumannii recombinant acid phosphatase; nickel dichloride; bovine serum albumin In water pH=6; Cooling with ice; Enzymatic reaction;

: 131-99-7
5'-inosine monophosphate

: 523-98-8, 57282-68-5
XMP

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; recombinant TgIMPDHFLAG from Toxoplasma gondii; NAD In various solvent(s) at 37℃; for 1h; pH=8.0; Enzyme kinetics;
With Escherichia coli B3 inosine monophosphate dehydrogenase; nicotinamide adenine dinucleotide Enzyme kinetics;
With mouse inosine monophosphate dehydrogenase type II; NAD; water Kinetics; Enzymatic reaction;
With ethylenediaminetetraacetic acid; human recombinant inosine monophosphate dehydrogenase type II; potassium chloride; nicotinamide adenine dinucleotide; 2-hydroxyethanethiol; diothiothreitol at 30℃; for 0.5h; pH=8; Kinetics; aq. buffer; Enzymatic reaction;
With recombinant N-terminal (His)6-tagged Mycobacterium tuberculosis H37Rv NAD-dependent inosine monophosphate dehydrogenase; NAD; water at 25℃; for 0.0833333h; pH=8; Kinetics; Concentration; Reagent/catalyst; aq. buffer; Enzymatic reaction;

: 131-99-7
5'-inosine monophosphate

: 95314-07-1
MopI2'p5'A

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) Ph3P, 2,2-dipyridyl disulfide, 2.) 0.1 M aq. NaI / dimethylsulfoxide / 0.67 h / Ambient temperature 2: aq. Pb(NO3)2, imidazole nitrate buffer / 24 h / 4 °C View Scheme

: 131-99-7
5'-inosine monophosphate

: 95314-06-0
MopA2'p5'I

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) Ph3P, 2,2-dipyridyl disulfide, 2.) 0.1 M aq. NaI / dimethylsulfoxide / 0.67 h / Ambient temperature 2: aq. Pb(NO3)2, imidazole nitrate buffer / 24 h / 4 °C View Scheme

: 15020-99-2
cis-dichloro(ethylenediamine)palladium(II)

: 131-99-7
5'-inosine monophosphate

: Pd(2+)*NH2CH2CH2NH2*Cl(1-)*C10H11N4O5PO3H2=Pd(NH2CH2CH2NH2)(C10H11N4O5PO3H2)Cl(1+)

Conditions

Conditions	Yield
In water Kinetics; byproducts: H2O; 25.1°C, I=0.10 (NaClO4), pH=4.5, varying conc. of Cl(1-) and inosine-5'-phosphate; not isolated, detd. by UV/VIS spectroscopy;

: [Ru(N,N,N',N'-ethylenediaminetetraacetato)(H2O)](1-)

: 131-99-7
5'-inosine monophosphate

: [Ru(ethylenediaminetetraacetate)(inosin-5'-monophosphate)](1-)

Conditions

Conditions	Yield
In water Kinetics; byproducts: H2O; pH 4.5, 0.1 M NaClO4, Ru concn. 5E-4 M, nucleotide concn. 0.005-0.025 M;15, 25, or 35°C;

: cis-dichloro(L-methionine)palladium(II)

: 16887-00-6
chloride

: silver perchlorate

: 131-99-7
5'-inosine monophosphate

: [Pd(L-methioninato)(inosine 5'-monophosphate)2](3-)

Conditions

Conditions	Yield
In water Kinetics; 0.01-0.2 M Cl(1-), 20-40°C, 0.1-125 MPa; not isolated, reaction followed by stopped-flow UV/VIS spectroscopy;

...Expand

: 14267-08-4
N,N,N',N'-tetramethylethylenediamine palladium(II) chloride

: 131-99-7
5'-inosine monophosphate

A: Pd(2+)*(N(CH3)2CH2CH2N(CH3)2)*2(OCH(CH2OPO(OH)2)(CHOH)2CH(C5H3N4O)) = {Pd(N(CH3)2C2H4N(CH3)2)(C10H13N4O8P)2}(2+)

B: Pd(2+)*(N(CH3)2C2H4N(CH3)2)*Cl(1-)*(OCH(CH2OPO(OH)2)(CHOH)2CH(C5H3N4O)) = {Pd(N(CH3)2C2H4N(CH3)2)(Cl)(C10H13N4O8P)}(1+)

Conditions

Conditions	Yield
In water Kinetics; byproducts: H2O; 25.1°C, I=0.10 (NaClO4), pH=4.5, varying conc. of Cl(1-) and inosine-5'-phosphate; not isolated, detd. by UV/VIS spectroscopy; ratio of products depending on concn. of ligand, Cl(1-) and reaction time;

...Expand

: 54831-91-3
(1,10-phenanthroline)(ethylenediamine)platinum(II)

: 131-99-7
5'-inosine monophosphate

: (1,10-phenanthroline)(ethylenediamine)platinum(II) inosine 5'-monophosphate adduct

Conditions

Conditions	Yield
25°C, pH 7-8, I=0.1 or 0.2 M NaCl; calorimetric titrn.;

: 166896-59-9
N,N,N',N'-tetraethylethylenediamine palladium(II) chloride

: 131-99-7
5'-inosine monophosphate

: cis-palladium(II)(inosine 5'-monophosphate)2(N,N,N',N'-tetraethylenediamine)

Conditions

Conditions	Yield
In water Kinetics; reaction of Pd(Et4en)Cl2 with inosine 5'-monophosphate in aq. soln. (pH 4.5) at room temp.; monitored by UV-spectroscopy;

: 137793-30-7
(5,6-dimethyl-1,10-phenanthroline)(ethylenediamine)platinum(II)

: 131-99-7
5'-inosine monophosphate

: (5,6-dimethyl-1,10-phenanthroline)(ethylenediamine)platinum(II) inosine 5'-monophosphate adduct

Conditions

Conditions	Yield
70°C, pH 8; (13)C-NMR;

: 118170-06-2
Ru{N'-(2-hydroxyethyl)ethylenediamine-N,N,N'-triacetate}(H2O)

: 131-99-7
5'-inosine monophosphate

: [Ru(N-hydroxyethylethylenediaminetriacetate)(inosin-5'-monophosphate)]

Conditions

Conditions	Yield
In water Kinetics; byproducts: H2O; pH 4.5, 0.1 M NaClO4, Ru concn. 5E-4 M, nucleotide concn. 0.005-0.025 M;15, 25, or 35°C;

: cis-aquated platinum(II) 5'-guanosine monophosphate aquo complex

: 131-99-7
5'-inosine monophosphate

: cis-aquated platinum(II) 5'-guanosine monophosphate 5'-inosine monophosphate complex

Conditions

Conditions	Yield
not isolated, detected by NMR;

: chromium(III) nitrate

: 131-99-7
5'-inosine monophosphate

: 2Cr(3+)*3OPOOOCH2CHCHOHCHOHCHON2CHC2NNHCHCO(2-)*10H2O=Cr2(O4PCH2CHCHOHCHOHCHON2CHC2NNHCHCO)3*10H2O

Conditions

Conditions	Yield
With nitric acid In water nucleotide was dissolved in H2O, HNO3 was added to pH=3, Cr(NO3)3 was dissolved in H2O, soln. were mixed and heated to 50°C for 1-2 h; cooled or EtOH was added, filtered, washed with H2O and EtOH, dried in vac. over P2O5; elem. anal.;

: cis-diamminediaquaplatinum(II) dinitrate

: 131-99-7
5'-inosine monophosphate

: cis-aquated platinum(II) 5'-inosine monophosphate complex

Conditions

Conditions	Yield
In water-d2 NMR monitoring; not isolated, detected by NMR;

INOSINIC ACID Chemical Properties

Product Name: Inosinic acid (131-99-7)

Molecular Formula: C₁₀H₁₃N₄O₈P
Molecular Weight: 348.206g/mol
Mol File: 131-99-7.mol
Einecs:205-045-1
Storage Temperature: -20°C
Ynonyms of Ethyl Inosinic acid viki (131-99-7) : 5’-inosinicacid ; inosine5’-phosphate ; inosinemonophosphate ; imp ; inosinic acid ; inosine 5'-monophosphate ; inosine-5'-monophosphoric acid ; 1-5'-p .

INOSINIC ACID Uses

Inosinic acid (131-99-7) and its salts such as disodium inosinate are used as flavour enhancers in the food industry,.

INOSINIC ACID Toxicity Data With Reference

1.	orl-rat LD50:16 g/kg	ARTODN Archives of Toxicology. 47 (1981),77.
2.	ipr-rat LD50:4850 mg/kg	ARTODN Archives of Toxicology. 47 (1981),77.
3.	scu-rat LD50:3900 mg/kg	ARTODN Archives of Toxicology. 47 (1981),77.
4.	ivn-rat LD50:2730 mg/kg	ARTODN Archives of Toxicology. 47 (1981),77.
5.	orl-mus LD50:12 g/kg	ARTODN Archives of Toxicology. 47 (1981),77.
6.	ipr-mus LD50:5400 mg/kg	ARTODN Archives of Toxicology. 47 (1981),77.
7.	scu-mus LD50:5480 mg/kg	ARTODN Archives of Toxicology. 47 (1981),77.
8.	ivn-mus LD50:3300 mg/kg	ARTODN Archives of Toxicology. 47 (1981),77.

INOSINIC ACID Consensus Reports

Reported in EPA TSCA Inventory.

INOSINIC ACID Safety Profile

Moderately toxic by subcutaneous and intravenous routes. When heated to decomposition it emits toxic fumes of PO_x and NO_x.

INOSINIC ACID Specification

Inosinic acid (131-99-7) is a nucleoside monophosphate. Inosinic acid is important in metabolism. It is the ribonucleotide of hypoxanthine and the first nucleotide formed during the synthesis of purine. It is formed by the deamination of adenosine monophosphate, and is hydrolysed to form inosine.Important derivatives of inosinic acid include purine nucleotides found in nucleic acids and adenosine triphosphate, which is used to store chemical energy in muscle and other tissues.

Product Name

IMP

Synthetic route

INOSINIC ACID Chemical Properties

INOSINIC ACID Uses

INOSINIC ACID Toxicity Data With Reference

INOSINIC ACID Consensus Reports

INOSINIC ACID Safety Profile

INOSINIC ACID Specification

Related Products

Hot Products