Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium carbonate In acetone for 0.5h; Heating; | 77% |
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide at 50℃; for 5h; | 58.7% |
With methanol; diethyl ether; sodium methylate | |
Williamson Ether Synthesis; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: boron tribromide / dichloromethane / 4 h / 10 °C 2: sodium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C View Scheme |
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water | 100% |
With ferrous(II) sulfate heptahydrate; dipotassium hydrogenphosphate; magnesium sulfate heptahydrate; D-glucose; potassium chloride; water; Sucrose In dimethyl sulfoxide at 27℃; for 288h; | 64% |
With hydrogenchloride In ethanol for 2h; Heating; | 7.0 g |
imperatorin
Prangenin
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethanol at 0℃; for 6.66667h; γ-Irradiation; | 100% |
With 3,3-dimethyldioxirane In acetone at 0℃; for 2h; | 99% |
With 3-chloro-benzenecarboperoxoic acid In chloroform at 0℃; for 2h; | 85% |
With 3-chloro-benzenecarboperoxoic acid In chloroform at 20℃; for 2h; | 67% |
Conditions | Yield |
---|---|
With bromine In acetic acid at 20℃; for 5h; Bromination; | 98% |
Conditions | Yield |
---|---|
With nitric acid In acetic acid for 1h; Oxidation; Heating; | 70% |
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In chloroform at 20℃; for 0.625h; γ-Irradiation; | A 66% B 34% |
imperatorin
A
heraclenol
B
bergapten
C
C16H20O7
D
C17H22O7
E
C16H18O6
F
C16H18O6
G
C17H20O6
H
C16H20O6
I
C16H18O6
Conditions | Yield |
---|---|
With Penicillium janthinellum AS; liquid potato medium In acetone at 27℃; for 120h; Microbiological reaction; | A 3.1% B 0.63% C 1% D 0.5% E 0.63% F 3 mg G 0.4% H 0.37% I 0.75% J 0.56% |
imperatorin
A
9-hydroxy-2,3,5,6-tetrahydro-furo[3,2-g]chromen-7-one
Conditions | Yield |
---|---|
With palladium on activated charcoal; acetic acid Hydrogenation; |
Conditions | Yield |
---|---|
With oxygen; methylene blue In methanol for 24h; Irradiation; | |
With oxygen; methylene blue In methanol for 24h; Product distribution; Mechanism; Irradiation; light and other sensitizers, effects of D2O and DABCO; further time; |
Conditions | Yield |
---|---|
In acetic acid at 25 - 30℃; for 100h; Irradiation; | A 246 mg B 23 mg |
In acetone at 25 - 30℃; for 100h; Irradiation; | A 26 mg B 25 mg |
Conditions | Yield |
---|---|
In methanol at 25 - 30℃; for 100h; Mechanism; Irradiation; different solvents; | A 73 mg B 22 mg C 11 mg |
In methanol at 25 - 30℃; for 100h; Irradiation; | A 73 mg B 22 mg C 11 mg |
Conditions | Yield |
---|---|
In various solvent(s) for 1h; Heating; | 4.6 g |
With N,N-diethylaniline for 1h; Heating; |
imperatorin
A
9-(3'-Hydroperoxy-3'-methyl-1'-butenyloxy)furo<3,2-g><1>benzopyran-7-one
B
9-(2'-Hydroperoxy-3'-methyl-3'-butenyloxy)furo<3,2-g><1>benzopyran-7-one
Conditions | Yield |
---|---|
With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane at -10℃; for 2.5h; Yield given. Yields of byproduct given; |
imperatorin
Conditions | Yield |
---|---|
at 200℃; under 0.5 Torr; |
imperatorin
A
9-(2'-Hydroperoxy-3'-methyl-3'-butenyloxy)furo<3,2-g><1>benzopyran-7-one
Conditions | Yield |
---|---|
With oxygen; 5,15,10,20-tetraphenylporphyrin In chloroform at 0℃; for 4h; γ-Irradiation; |
imperatorin
Dihydro-8-hydroxypsoralen
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol at 20℃; under 760 Torr; for 0.5h; |
imperatorin
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In hexane at 20℃; for 2h; |
imperatorin
(+/-)-5-(3''-bromo-2''-hydroxy-3''-methylbutanoxy)-psoralen
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / MCPBA / CHCl3 / 2 h / 0 °C 2: 70 percent / HBr / diethyl ether; benzene / 1 h / 5 °C View Scheme |
imperatorin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85 percent / MCPBA / CHCl3 / 2 h / 0 °C 2: 70 percent / HBr / diethyl ether; benzene / 1 h / 5 °C 3: pyridine / 24 h / Ambient temperature View Scheme |
imperatorin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85 percent / MCPBA / CHCl3 / 2 h / 0 °C 2: 70 percent / HBr / diethyl ether; benzene / 1 h / 5 °C 3: pyridine / 24 h / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 mg / acetone / 100 h / 25 - 30 °C / Irradiation 2: potassium carbonate / acetone / 6 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water; methanol 2: potassium carbonate / acetone / Reflux; Inert atmosphere View Scheme |
imperatorin
O-acetylxanthotoxol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26 mg / acetone / 100 h / 25 - 30 °C / Irradiation 2: 2 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 7.0 g / dil. HCl / ethanol / 2 h / Heating 2: 2.1 g / CH3COONa / 3 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 14.5 g / HCl / ethanol / 2 h / Heating 2: pyridine / Heating View Scheme |
imperatorin
allo-imperatorin acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 25 mg / acetone / 100 h / 25 - 30 °C / Irradiation 2: 2 h / Heating View Scheme |
imperatorin
9-(phenylmethoxy)-7H-furo[3,2-g][1]benzopyran-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 14.5 g / HCl / ethanol / 2 h / Heating 2: K2CO3 / acetone / Heating View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water; methanol 2: potassium carbonate / acetone / Reflux; Inert atmosphere View Scheme |
imperatorin
Alloimperatorin methyl ether
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-diethylaniline / 1 h / Heating 2: K2CO3 / acetone / 24 h / Heating View Scheme |
imperatorin
9-(2-propen-1-yloxy)-7H-furo[3,2-g][1]benzopyran-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 14.5 g / HCl / ethanol / 2 h / Heating 2: K2CO3 / acetone / Heating View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water; methanol 2: potassium carbonate / acetone / Reflux; Inert atmosphere View Scheme |
imperatorin
4-Allyl-9-hydroxy-furo[3,2-g]chromen-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 14.5 g / HCl / ethanol / 2 h / Heating 2: K2CO3 / acetone / Heating 3: N,N-diethylaniline / 1 h / Heating View Scheme |
imperatorin
4-Allyl-9-methoxy-furo[3,2-g]chromen-7-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 14.5 g / HCl / ethanol / 2 h / Heating 2: K2CO3 / acetone / Heating 3: N,N-diethylaniline / 1 h / Heating 4: K2CO3 / acetone / 24 h / Heating View Scheme |
The Imperatorin, with the CAS registry number 482-44-0, is also known as 7H-Furo[3,2-g][1]benzopyran-7-one,9-[(3-methyl-2-buten-1-yl)oxy]-. It belongs to the product categories of Coumarins; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS number is 207-581-1. This chemical's molecular formula is C16H14O4 and molecular weight is 270.28. What's more, its systematic name is 9-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one. Its classification code is Mutation data. This chemical can be used for curing vitiligo, and it is also effective ingredients of dahurica treatment psoriasis. In addition, it has the functions of calm, spasmolysis, asthma relief, anti-inflammatory and antibiosis. It is biosynthesized from umbelliferone, a coumarin derivative.
Physical properties of Imperatorin are: (1)ACD/LogP: 2.983; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.98; (4)ACD/LogD (pH 7.4): 2.98; (5)ACD/BCF (pH 5.5): 108.97; (6)ACD/BCF (pH 7.4): 108.97; (7)ACD/KOC (pH 5.5): 999.78; (8)ACD/KOC (pH 7.4): 999.78; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 48.67 Å2; (13)Index of Refraction: 1.606; (14)Molar Refractivity: 75.019 cm3; (15)Molar Volume: 217.453 cm3; (16)Polarizability: 29.74×10-24cm3; (17)Surface Tension: 46.73 dyne/cm; (18)Density: 1.243 g/cm3; (19)Flash Point: 224.936 °C; (20)Enthalpy of Vaporization: 70.681 kJ/mol; (21)Boiling Point: 448.319 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.
Preparation: this chemical can be prepared by 9-acetoxy-furo[3,2-g]chromen-7-one and 1-chloro-3-methyl-but-2-ene by heating. This reaction will need reagents 18-crown-6, K2CO3 and solvent acetone with the reaction time of 30 min. The yield is about 77%.
Uses of Imperatorin: it can be used to produce furo[3,2-g]chromene-4,7,9-trione by heating. It will need reagent fuming HNO3 and solvent acetic acid with the reaction time of 1 hour. The yield is about 70%.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C/3Oc2c(OC\C=C(/C)C)c1occc1cc2\C=C\3
(2)Std. InChI: InChI=1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3
(3)Std. InChIKey: OLOOJGVNMBJLLR-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 330mg/kg (330mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 21, Pg. 499, 1948. | |
mouse | LDLo | parenteral | 600mg/kg (600mg/kg) | "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 689, 1955. |
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