Product Name

  • Name

    Indeloxazine hydrochloride

  • EINECS
  • CAS No. 65043-22-3
  • Article Data2
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 169-170°; mp 155-156°
  • Formula C14H17 N O2 . Cl H
  • Boiling Point 401.4°C at 760 mmHg
  • Molecular Weight 267.755
  • Flash Point 160.3°C
  • Transport Information
  • Appearance
  • Safety Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.
  • Risk Codes
  • Molecular Structure Molecular Structure of 65043-22-3 (Indeloxazine hydrochloride)
  • Hazard Symbols
  • Synonyms Morpholine,2-[(1H-inden-7-yloxy)methyl]-, hydrochloride (9CI); CI 874; Elen; Indeloxazinehydrochloride; Noin; YM 08054; YM 08054-1
  • PSA 30.49000
  • LogP 2.75390

Synthetic route

(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine
64966-73-0

(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 17h; Heating;73.4%
sulfuric acid mono-(2-amino-ethyl ester)
926-39-6

sulfuric acid mono-(2-amino-ethyl ester)

1-(inden-7-yloxy)-2,3-epoxypropane
30190-85-3

1-(inden-7-yloxy)-2,3-epoxypropane

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In methanol 1.) 55 deg C, 16 h; 2.) iso-PrOH, acetone, 0-5 deg C, 15 min.;73%
(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine
60929-58-0

(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
2: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
R,S-2-hydroxymethyl-4-benzylmorpholine
40987-24-4

R,S-2-hydroxymethyl-4-benzylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / H2 / 10percent Pd-C / methanol / Ambient temperature
2: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature
3: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature
4: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
5: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
6: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
morpholin-2-ylmethanol
103003-01-6

morpholin-2-ylmethanol

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature
2: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature
3: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
4: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
5: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
(+/)-2-hydroxymethyl-4-triphenylmethylmorpholine
131965-77-0

(+/)-2-hydroxymethyl-4-triphenylmethylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature
2: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
3: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
4: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
2-(p-toluenesulfonyloxymethyl)-4-triphenylmethylmorpholine
60929-57-9

2-(p-toluenesulfonyloxymethyl)-4-triphenylmethylmorpholine

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
2: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
3: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme
4-morpholin-2-ylmethoxy-indan-1-ol
60929-60-4

4-morpholin-2-ylmethoxy-indan-1-ol

2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium chloride In ethanol; chloroform; acetone
2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

(+)-indeloxazine hydrochloride, (+)-YM-08054 hydrochloride
65043-22-3, 76489-35-5, 104908-10-3, 104908-43-2

(+)-indeloxazine hydrochloride, (+)-YM-08054 hydrochloride

Conditions
ConditionsYield
Yield given;
2-(7-indenyloxymethyl)-morpholine hydrochloride
65043-22-3

2-(7-indenyloxymethyl)-morpholine hydrochloride

(-)-indeloxazine hydrochloride; (-)-YM-08054 hydrochloride
65043-22-3, 76489-35-5, 104908-10-3, 104908-43-2

(-)-indeloxazine hydrochloride; (-)-YM-08054 hydrochloride

Conditions
ConditionsYield
Yield given;

Indeloxazine hydrochloride Chemical Properties

Product Name: Indeloxazine hydrochloride
CAS Registry Number: 65043-22-3
IUPAC Name: 2-(3H-inden-4-yloxymethyl)morpholine hydrochloride
Molecular Weight: 267.75122 [g/mol]
Molecular Formula: C14H18ClNO2
H-Bond Donor: 2
H-Bond Acceptor: 3
Flash Point: 160.3 °C
Enthalpy of Vaporization: 65.24 kJ/mol
Boiling Point: 401.4 °C at 760 mmHg
Vapour Pressure: 1.18E-06 mmHg at 25°C
Following is the molecular structure of Indeloxazine hydrochloride (CAS NO.65043-22-3) is:

Indeloxazine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 60mg/kg (60mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse LD50 intraperitoneal 50400ug/kg (50.4mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 1181, 1988.
mouse LD50 intravenous 47mg/kg (47mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 238, Pg. 81, 1979.
mouse LD50 oral 340mg/kg (340mg/kg)   United States Patent Document. Vol. #4297356,
mouse LD50 subcutaneous 245mg/kg (245mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat LD50 intravenous 77300ug/kg (77.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat LD50 oral 502mg/kg (502mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat LD50 subcutaneous 206mg/kg (206mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985

Indeloxazine hydrochloride Safety Profile

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl. 
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Indeloxazine hydrochloride Specification

 Indeloxazine hydrochloride , its cas register number is 65043-22-3. It also can be called Indeloxazine hydrochloride [USAN:JAN] ; (+-)-2-((Inden-7-yloxy)methyl)morpholine hydrochloride ; 2-((1H-Inden-7-yloxy)methyl)morpholine hydrochloride ; CI 874 ; Indeloxazine HCl ; Indeloxazine hydrochloride ; Morpholine, 2-((1H-inden-7-yloxy)methyl)-, hydrochloride, (+-)- ; UNII-15QZ6NE84E ; YM 08054-1 ; YM-08054-1 .

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