Product Name

  • Name

    INDOMETHACIN SODIUM SALT TRIHYDRATE

  • EINECS
  • CAS No. 74252-25-8
  • Density
  • Solubility
  • Melting Point 162oC
  • Formula C19H16 Cl N O4 . 3 H2 O . Na
  • Boiling Point
  • Molecular Weight 401.85
  • Flash Point
  • Transport Information
  • Appearance
  • Safety A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and Cl−.
  • Risk Codes  A poison
  • Molecular Structure Molecular Structure of 74252-25-8 (INDOMETHACIN SODIUM SALT TRIHYDRATE)
  • Hazard Symbols A poison by ingestion.
  • Synonyms 1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodium salt, trihydrate (9CI)
  • PSA 68.53000
  • LogP 3.92730

Indomethacin sodium trihydrate Chemical Properties

IUPAC Name:  2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetic acid
CAS: 74252-25-8
Following is the Molecular Structure of Indomethacin sodium trihydrate (74252-25-8):

SMILES: Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)O
InChI: InChI=1/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChIKey: CGIGDMFJXJATDK-UHFFFAOYAA
Std.InChI: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
Std.InChIKey: CGIGDMFJXJATDK-UHFFFAOYSA-N
Molecular Formula: C19H21ClNNaO7
Molecular Weight: 357.7876
Boiling Point: 499.4℃ at 760mmHg
Flash Point: 255.8℃
Molar Volume: 269.5cm3
Density: 1.32g/cm3
Index of Refraction: 1.619
Molar Refractivity: 94.59cm3
Surface Tension: 47.4dyne/cm
Polarizability: 37.49 10-24cm3
Enthalpy of Vaporization: 80.85kJ/mol
Vapour Pressure:  8.61E-11mmHg at 25℃

Indomethacin sodium trihydrate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 unreported > 81mg/kg (81mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
mouse LD50 intravenous 23mg/kg (23mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: PERITONITIS

GASTROINTESTINAL: OTHER CHANGES		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
mouse LD50 oral 21mg/kg (21mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: PERITONITIS

GASTROINTESTINAL: OTHER CHANGES		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
mouse LD50 subcutaneous 21mg/kg (21mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: PERITONITIS		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
rat LD50 intravenous 23mg/kg (23mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: PERITONITIS

GASTROINTESTINAL: OTHER CHANGES		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
rat LD50 oral 21mg/kg (21mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: PERITONITIS

GASTROINTESTINAL: OTHER CHANGES		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
rat LD50 subcutaneous 21mg/kg (21mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: PERITONITIS

GASTROINTESTINAL: OTHER CHANGES		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.

Indomethacin sodium trihydrate Safety Profile

A poison by ingestion, subcutaneous, and intravenous routes.

Indomethacin sodium trihydrate Specification

 Indomethacin sodium trihydrate (74252-25-8),which also can be called for Indomethacin sodium salt trihydrate ; 1h-Indole-3-acetic acid,1-(4-chlorobenzoyl)-5-methoxy-2-methyl-,sodium salt,trihydrate ; Indometacin farnesil .When Indomethacin sodium trihydrate (74252-25-8) was heated,it emits toxic vapors of NOx and Cl− .

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