Product Name

  • Name

    LOFEPRAMINE HYDROCHLORIDE

  • EINECS 248-002-2
  • CAS No. 26786-32-3
  • Density g/cm3
  • Solubility Soluble in DMSO: ~24 mg/mL
  • Melting Point 152-154°
  • Formula C26H27 Cl N2 O . Cl H
  • Boiling Point 575 °C at 760 mmHg
  • Molecular Weight 455.46
  • Flash Point 301.6 °C
  • Transport Information
  • Appearance off-white solid
  • Safety Poison by intraperitoneal route. Experimental reproductive effects. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl. See also AMINES.
  • Risk Codes 22-37-53
  • Molecular Structure Molecular Structure of 26786-32-3 (LOFEPRAMINE HYDROCHLORIDE)
  • Hazard Symbols Xn
  • Synonyms Acetophenone,4'-chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,monohydrochloride (8CI); Ethanone,1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,monohydrochloride (9CI); Gamanil; Gamonil; Leo 640 hydrochloride; Lofepraminehydrochloride; Lopramine hydrochloride; Timelit; Tymelyt; WHR 2908A
  • PSA 23.55000
  • LogP 6.64850

Iopramine hydrochloride Chemical Properties

IUPAC Name: 1-(4-Chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone hydrochloride
Synonyms of Iopramine hydrochloride (CAS NO.26786-32-3) : 1-(4-Chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl](methyl)amino}ethanone hydrochloride (1:1) ; 4'-Chloro-2-((3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl)methylamino)acetophenone Monohydrochloride ; 5-(3-((p-Chlorobenzoylmethyl)-N-methylamino)propyl)-5H-dibenz[b,f]azepine Hydrochloride ; Amplit ; Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1) ; Gamanil ; Lopramine Hydrochloride
CAS NO:26786-32-3
Molecular Formula:C26H28Cl2N2O
Molecular Weight :455.42
Molecular Structure :
EINECS: 248-002-2
Flash Point: 301.6 °C
Enthalpy of Vaporization: 86.14 kJ/mol
Boiling Point: 575 °C at 760 mmHg
Vapour Pressure: 3.17E-13 mmHg at 25°C
Storage temp: 2-8°C
Solubility : DMSO: ~24 mg/mL
Appearance: Iopramine hydrochloride (CAS NO.26786-32-3) is off-white solid.

Iopramine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 920mg/kg (920mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 877, 1976.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.
rat LD50 oral > 5gm/kg (5000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 877, 1976.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970.

 

Iopramine hydrochloride Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. An experimental teratogen. Mutation data reported. When Iopramine hydrochloride (CAS NO.26786-32-3) is heated to decomposition, it emits toxic fumes of NOx and HCl. See also AMINES.

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