Product Name

  • Name

    iproclozide

  • EINECS
  • CAS No. 3544-35-2
  • Article Data4
  • CAS DataBase
  • Density 1.175g/cm3
  • Solubility
  • Melting Point 93-94°
  • Formula C11H15 Cl N2 O2
  • Boiling Point 336.5°Cat760mmHg
  • Molecular Weight 242.705
  • Flash Point 157.3°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also HYDRAZINE.
  • Risk Codes
  • Molecular Structure Molecular Structure of 3544-35-2 (iproclozide)
  • Hazard Symbols
  • Synonyms Aceticacid, (4-chlorophenoxy)-, 2-(1-methylethyl)hydrazide (9CI); Acetic acid,(p-chlorophenoxy)-, 2-isopropylhydrazide (7CI,8CI); Iproclozid; Iproclozide; PC603; PU 603; Sursum; p-Chlorophenoxyacetic acid 2-isopropylhydrazide
  • PSA 53.85000
  • LogP 2.97920

Iproclozide Chemical Properties

Empirical Formula of Iproclozide (CAS NO.3544-35-2): C11H15ClN2O2
Molecular Weight: 242.702 
EINECS: 222-589-5
Index of Refraction: 1.527
Density: 1.175 g/cm3
Flash Point: 157.3 °C
Enthalpy of Vaporization: 57.97 kJ/mol
Boiling Point: 336.5 °C at 760 mmHg
Vapour Pressure: 0.000111 mmHg at 25 °C
Structure of Iproclozide (CAS NO.3544-35-2):
                      
IUPAC Name: 2-(4-Chlorophenoxy)-N'-propan-2-ylacetohydrazide
Canonical SMILES: CC(C)NNC(=O)COC1=CC=C(C=C1)Cl
InChI: InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15)
InChIKey: GGECDTUJZOXAAR-UHFFFAOYSA-N

Iproclozide Uses

 Iproclozide (CAS NO.3544-35-2) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant.

Iproclozide Toxicity Data With Reference

1.    

orl-rat LD50:550 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,394.
2.    

orl-mus LD50:278 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,394.
3.    

ipr-mus LD50:219 mg/kg

     PCJOAU    Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 11 (1977),887.

Iproclozide Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition Iproclozide (CAS NO.3544-35-2) emits very toxic fumes of Cl− and NOx. See also HYDRAZINE.

Iproclozide Specification

 Iproclozide , its cas register number is 3544-35-2. It also can be called 1-(p-Chlorophenoxyacetyl)-2-isopropyl hydrazine ; p-Chlorophenoxyacetic acid 2-isopropylhydrazide ; (4-Chlorophenoxy)acetic acid 2-(1-methylethyl)hydrazide ; and Acetic acid, (4-chlorophenoxy)-, 2-(1-methylethyl)hydrazide (9CI) . It has since been discontinued, and has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.

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