Product Name

  • Name

    Ramifenazone

  • EINECS 222-791-3
  • CAS No. 3615-24-5
  • Article Data10
  • CAS DataBase
  • Density 1.14 g/cm3
  • Solubility
  • Melting Point 80°
  • Formula C14H19N3O
  • Boiling Point 348.5 °C at 760 mmHg
  • Molecular Weight 245.324
  • Flash Point 164.6 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 3615-24-5 (Ramifenazone)
  • Hazard Symbols
  • Synonyms Antipyrine,4-(isopropylamino)- (6CI,7CI,8CI);1-Phenyl-2,3-dimethyl-4-(isopropylamino)-2-pyrazolin-5-one;1-Phenyl-2,3-dimethyl-4-isopropylaminopyrazolone;4-(Isopropylamino)antipyrine;4-(Isopropylamino)phenazone;4-Isopropylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;4-Monoisopropylamino-1-phenyl-2,3-dimethyl-5-pyrazolone;Isopirina;Isopropylaminoantipyrine;Isopropylaminophenazone;Isopyrine;Ramifenazone;
  • PSA 38.96000
  • LogP 2.37770

Isopyrin Chemical Properties

The Molecular formula of 4-(ISOPROPYLAMINO)ANTIPYRINE (C14H19N3O):C14H19N3O   
The Molecular Weight of 4-(ISOPROPYLAMINO)ANTIPYRINE (C14H19N3O):245.32 
The Molecular Structure of 4-(ISOPROPYLAMINO)ANTIPYRINE (C14H19N3O) is:
Density:1.14 g/cm3  
Boiling point:348.5 °C at 760 mmHg
Flash point:164.6 °C     
Index of Refraction:1.594  
Molar Refractivity:72.71 cm3 
Molar Volume:214.1 cm3 
Polarizability:28.82 10-24cm3 
Surface Tension:46.4 dyne/cm
Enthalpy of Vaporization:59.29 kJ/mol  
Appearance:white crystalline powder
IUPAC Name: 1,5-dimethyl-2-phenyl-4-(propan-2-ylamino)pyrazol-3-one
Synonyms: RAMIFENAZONE ; 4-isopropylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one ; Ramiphenazone ; 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)amino-2-phenyl- ; ISOPYRIN=RAMIFENAZONE,S.DORT ; 1,2-Dihydro-1,5-dimethyl-4-isopropylamino-2-phenyl-3H-pyrazol-3-one ; isopyrin ; 1,2-Dihydro-1,5-dimethyl-4-[(1-methylethyl)amino]-2-phenyl-3H-pyrazol-3-one

Isopyrin Uses

It is used as anti-inflammatory analgesic.

Isopyrin Toxicity Data With Reference

1.    

ipr-rat LD50:715 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 20 (1970),1024.
2.    

ivn-rat LD50:450 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 10 (1960),665.
3.    

ims-rat LD50:820 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 10 (1960),665.
4.    

orl-mus LD50:1070 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 20 (1970),1024.
5.    

ipr-mus LD50:690 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 10 (1960),665.
6.    

ivn-mus LD50:370 mg/kg

     AEPPAE    Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 233 (1958),365.
7.    

ipr-ham LD50:567 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 20 (1970),1024.

Isopyrin Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and intramuscular routes. An analgesic, antipyretic, and anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.

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