L-Epinephrine hydrochloride supplier

Name
Epinephrine Hydrochloride
EINECS 200-230-3
CAS No. 55-31-2
Article Data1
CAS DataBase
Density
Solubility
Melting Point 157 °C
Formula C₉H₁₄ClNO₃
Boiling Point 413.1 °C at 760 mmHg
Molecular Weight 219.668
Flash Point 207.9 °C
Transport Information
Appearance crystals
Safety
Risk Codes R24/25; R36/37/38
Molecular Structure
Hazard Symbols
Synonyms 1,2-Benzenediol,4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochloride (9CI);1,2-Benzenediol,4-[1-hydroxy-2-(methylamino)ethyl]-, hydrochloride, (R)-;Benzyl alcohol,3,4-dihydroxy-a-[(methylamino)methyl]-,hydrochloride, (-)- (8CI);(-)-Adrenaline hydrochloride;(-)-Epinephrinehydrochloride;Adrenalin chloride;Adrenalin hydrochloride;Adrenalinechlorhydrate;Adrenaline chloride;Adrenaline hydrochloride;Epinephrinechloride;Epinephrine hydrochloride;Gelatin-Epinephrine;Glaucon;SupranephrinSolution;Suprarenin hydrochloride;Tonogen;l-Adrenaline chloride;l-Adrenalinehydrochloride;l-Epinephrine chloride;l-Methylaminoethanolcatechol hydrochloride;
PSA 72.72000
LogP 1.54350

Synthetic route

: C44H36N4O12P2(2-)*C9H13NO3*H(1+)

A: 55-31-2
epinephrine hydrochloride

B: C44H36N4O12P2(2-)

Conditions

Conditions	Yield
In d(4)-methanol; water-d2 Equilibrium constant;

L-Epinephrine hydrochloride Chemical Properties

IUPAC Name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]benzene-1,2-diol hydrochloride
Synonyms of L-Epinephrine hydrochloride (CAS NO.55-31-2): (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol hydrochloride ; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol hydrochloride ; Adrenalin chloride ; Epinephrine chloride ; l-Methylaminoethanolcathechol hydrochloride
CAS NO: 55-31-2
Molecular Formula: C₉H₁₄ClNO₃
Molecular Weight: 219.67
Molecular Structure:
EINECS: 200-230-3
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 6
Polar Surface Area: 30.93 Å²
Flash Point: 207.9 °C
Melting Poin: 157°C
Boiling Point: 413.1 °C at 760 mmHg
Enthalpy of Vaporization: 70.21 kJ/mol
Vapour Pressure: 1.45E-07 mmHg at 25°C
Appearance: crystals
SMILES: Cl.Oc1ccc(cc1O)[C@@H](O)CNC
InChI: InChI=1/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H/t9-;/m0./s1
InChIKey: ATADHKWKHYVBTJ-FVGYRXGTBN
Std. InChI: InChI=1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H/t9-;/m0./s1
Std. InChIKey: ATADHKWKHYVBTJ-FVGYRXGTSA-N

L-Epinephrine hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intravenous	200ug/kg (0.2mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963.
guinea pig	LDLo	subcutaneous	2mg/kg (2mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963.
mouse	LD50	intraperitoneal	4664ug/kg (4.664mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 110, 1947.
mouse	LD50	intravenous	140ug/kg (0.14mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA	European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.
mouse	LD50	subcutaneous	1980ug/kg (1.98mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946.
mouse	LDLo	oral	50mg/kg (50mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963.
rat	LD50	intraduodenal	35mg/kg (35mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat	LD50	oral	24mg/kg (24mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat	LD50	subcutaneous	5mg/kg (5mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat	LDLo	intravenous	50ug/kg (0.05mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925.

L-Epinephrine hydrochloride Consensus Reports

Reported in NTP Carcinogenesis Studies (Inhalation); Inadequate Study: rat, mouse NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-380 ,1990. .

L-Epinephrine hydrochloride Safety Profile

Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also VASOTONIN and other adrenalin compounds.
Safety Information aboout L-Epinephrine hydrochloride (CAS NO.55-31-2):
RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup: II

L-Epinephrine hydrochloride Specification

Health Hazard of L-Epinephrine hydrochloride (CAS NO.55-31-2): Adverse reactions include restlessness; anxiety; headache; tremor; weakness; dizziness; pallor; respiratory difficulties; palpitation; nausea and vomiting.

Product Name

Epinephrine Hydrochloride