• Name

  L-Threonic acid calcium salt

• EINECS 615-158-1
• CAS No. 70753-61-6
• Article Data9
• CAS DataBase
• Density
• Solubility Soluble in water. Sparingly soluble in methanol.
• Melting Point >300 ºC
• Formula C4H8 O5 . 1/2 Ca
• Boiling Point 518.9oC at 760 mmHg
• Molecular Weight 310.271
• Flash Point 281.7oC
• Transport Information
• Appearance
• Safety S22;S24/25
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms Butanoicacid, 2,3,4-trihydroxy-, calcium salt (2:1), [R-(R*,S*)]-; Calcium L-threonate
• PSA 183.21000
• LogP -4.64830

Synthetic route

50-81-7

ascorbic acid

70753-61-6

calcium L-threonate

Conditions

Conditions	Yield
With dihydrogen peroxide; calcium carbonate In water at 5 - 70℃; for 18h;	94.6%
Stage #1: ascorbic acid With calcium carbonate In water at 0 - 5℃; Stage #2: With dihydrogen peroxide In water at 5 - 75℃; for 18h; Stage #3: With methanol In water at 20 - 50℃; for 12h;	94.6%
With dihydrogen peroxide; calcium carbonate In water at 0 - 20℃; for 18h;	85%

70753-61-6

calcium L-threonate

21730-93-8

L-threonic acid-4-lactone

Conditions

Conditions	Yield
With oxalic acid; toluene-4-sulfonic acid In acetonitrile for 3h; Reflux;	94%
With oxalic acid; toluene-4-sulfonic acid In acetonitrile Reflux;	93%

67-56-1

methanol

70753-61-6

calcium L-threonate

88824-11-7

methyl 2,4-dibromo-2,4-dideoxy-L-erythronate

Conditions

Conditions	Yield
Stage #1: calcium L-threonate With hydrogen bromide; acetic acid for 24h; Stage #2: methanol Heating;	90.2%
Stage #1: calcium L-threonate With hydrogen bromide In acetic acid for 24h; Stage #2: methanol In acetic acid at 20℃; for 14h; Reflux;	90.2%
With hydrogen bromide 1.) acetic acid, room temperature, 24 h, 2.) boiled, 2 h; Yield given. Multistep reaction;

2687-43-6

O-benzylhydoxylamine hydrochloride

70753-61-6

calcium L-threonate

97764-61-9

L-threonic acid (benzyloxy)amide

Conditions

Conditions	Yield
With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water for 4h;	72.4%

98-88-4

benzoyl chloride

70753-61-6

calcium L-threonate

538368-86-4

2′,3′-di-O-benzoyl-L-threonolactone

Conditions

Conditions	Yield
Stage #1: calcium L-threonate With Dowex 50WX4-50 In water at 70℃; for 0.5h; Stage #2: With toluene-4-sulfonic acid In acetonitrile for 1h; Heating; Stage #3: benzoyl chloride With pyridine at 20℃; for 10h;	60%

98-88-4

benzoyl chloride

70753-61-6

calcium L-threonate

91345-19-6

2′-O-benzoyl-L-threonolactone

Conditions

Conditions	Yield
Stage #1: calcium L-threonate In water at 70℃; for 0.5h; Stage #2: With toluene-4-sulfonic acid In acetonitrile for 23h; Reflux; Stage #3: benzoyl chloride With 1H-imidazole In acetonitrile at 0 - 20℃;	45%

70753-61-6

calcium L-threonate

117069-13-3

(2S,3S)-2,4-Dibromo-3-hydroxy-butyric acid

Conditions

Conditions	Yield
With hydrogen bromide; acetic anhydride; acetic acid for 24h; Ambient temperature;
With hydrogen bromide In acetic acid for 1.5h; Ambient temperature;

67-56-1

methanol

70753-61-6

calcium L-threonate

137460-62-9

methyl (2R,3S)-2,3,4-trihydroxybutanoate

Conditions

Conditions	Yield
With hydrogenchloride at 37℃; for 120h;

70753-61-6

calcium L-threonate

7306-96-9

L-threonic acid

Conditions

Conditions	Yield
With Amberlite IR-120 In water at 50℃;

L-Threonic acid calcium salt Chemical Properties

L-Threonic acid calcium salt Uses

L-Threonic acid calcium salt Safety Profile