Product Name

  • Name

    Levobunolol hydrochloride

  • EINECS 248-725-3
  • CAS No. 27912-14-7
  • Density
  • Solubility
  • Melting Point 209-211°
  • Formula C17H25NO3.HCl
  • Boiling Point 464.4 °C at 760 mmHg
  • Molecular Weight 327.89
  • Flash Point 234.7 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 27912-14-7 (Levobunolol hydrochloride)
  • Hazard Symbols
  • Synonyms (-)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalene-1(2H)-one hydrochloride;Vistagan;(2S)-N-(tert-butyl)-2-hydroxy-3-[(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]propan-1-aminium chloride;Betagan (TN);Prestwick_167;Levobunolol hydrochloride (JAN/USP);1(2H)-Naphthalenone,5-[(2S)-3-[(1,1- dimethylethyl)amino]-2-hydroxypropoxy]-3,4- dihydro-,hydrochloride;Levobunolol hydrochloride [USAN];(-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochloride;1(2H)-Naphthalenone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-, hydrochloride, (-)-;Betagan;
  • PSA 58.56000
  • LogP 3.52630

LEVOBUNOLOL HYDROCHLORIDE Chemical Properties

Product Name: Levobunolol hydrochloride (CAS NO.27912-14-7)


Molecular Formula: C17H26ClNO3
Molecular Weight: 327.85g/mol
Mol File: 27912-14-7.mol
Einecs: 248-725-3
Appearance: Glaucoma drug
Boiling point: 464.4 °C at 760 mmHg
Flash Point: 234.7 °C
Enthalpy of Vaporization: 76.47 kJ/mol
Vapour Pressure: 2.01E-09 mmHg at 25°C
H-Bond Donor: 3
H-Bond Acceptor: 4

LEVOBUNOLOL HYDROCHLORIDE Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 100mg/kg (100mg/kg)   General Pharmacology. Vol. 17, Pg. 373, 1986.
hamster LD50 oral 435mg/kg (435mg/kg)   General Pharmacology. Vol. 17, Pg. 373, 1986.
man TDLo ocular 8571nL/kg/9W- (8571mL/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE		 American Heart Journal. Vol. 127, Pg. 689, 1994.
mouse LD50 intravenous 78mg/kg (78mg/kg)   General Pharmacology. Vol. 17, Pg. 373, 1986.
mouse LD50 oral 1220mg/kg (1220mg/kg)   "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980Vol. -, Pg. 317, 1980.
rat LD50 intravenous 25mg/kg (25mg/kg)   General Pharmacology. Vol. 17, Pg. 373, 1986.
rat LD50 oral 700mg/kg (700mg/kg)   General Pharmacology. Vol. 17, Pg. 373, 1986.
women TDLo ocular 1uL/kg/12H-I (0.001mL/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION Medical Journal of Australia. Vol. 161, Pg. 576, 1994.

LEVOBUNOLOL HYDROCHLORIDE Safety Profile

A poison by ingestion and intravenous routes. Questionable carcinogen with experimental neoplastigenic data reported. When heated to decomposition it emits toxic vapors of NOx and HCl.

LEVOBUNOLOL HYDROCHLORIDE Specification

 Levobunolol hydrochloride ,its CAS NO. is 27912-14-7,the synonyms is (-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2h)-naphthalenone ; (-)-Rochlorid;3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2h)-naphthalenonhyd ; Betagan;gotensin ; l-Bunololhydrochloride ; Vistagan ; W7000a .

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