-
Name
lasiocarpine
- EINECS
- CAS No. 303-34-4
- Density 1.21g/cm3
-
Solubility
Stability
- Stable, but is readily hydrolyzed in basic solution and readily oxidized by oxidizing agents. Reacts slowly with atmospheric oxygen.
Toxicology
- Poison. Experimental carcinogen. Possible human ca
- Melting Point 97 C
- Formula C21H33 N O7
- Boiling Point 519.8°Cat760mmHg
- Molecular Weight 411.55
- Flash Point 268.1°C
- Transport Information
- Appearance colourless to beige crystalline solid
- Safety Suspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, intraperitoneal, and parenteral routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms 2-Butenoicacid, 2-methyl-,7-[[2,3-dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-ylester, [1S-[1a(Z),7[S*(R*)],7aa]]-; Lasiocarpine (6CI,7CI,8CI);(-)-Lasiocarpine; 7-Angelyleuropine; Europine 7-angelate; NSC 30625
- PSA 105.53000
- LogP 0.89670
Lasiocarpine Chemical Properties
IUPAC Name: [(7S,8R)-7-[(Z)-2-Methylbut-2-enoyl]oxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2,3-dihydroxy-2-[(1S)-1-methoxyethyl]-3-methylbutanoate
Molecular Formula: C21H33NO7
Molecular Weight: 411.55g/mol
Freely Rotating Bonds: 12
Polar Surface Area: 83.53 Å2
Index of Refraction: 1.544
Molar Refractivity: 106.91 cm3
Molar Volume: 338.2 cm3
Polarizability: 42.38 ×10-24cm3
Surface Tension: 49.7 dyne/cm
Density: 1.21 g/cm3
Flash Point: 268.1 °C
Enthalpy of Vaporization: 91.21 kJ/mol
Boiling Point: 519.8 °C at 760 mmHg
Vapour Pressure: 5.63E-13 mmHg at 25°C
The Cas Register Number of Lasiocarpine is 303-34-4 .The chemical synonyms of Lasiocarpine (CAS No. 303-34-4) are Lasiocarpine ; 2-Butenoic acid, 2-methyl-, 7[[(2,3-dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy] methyl]-2,3,5,7a-tetrahydro-1h-prrolizin-1-yl ester, [1s-[1alpha(z), 7(2s*, 3r*), 7aalpha)]- ; (Z)-2-Methyl-2-butenoic acid (1s)-7-[[[(2r)-2,3-dihydroxy-2-[(s)-1-methoxyethyl]-3-methylbutanoyl]oxy]methyl]-2,3,5,7aβ-tetrahydro-1h-pyrrolizin-1-yl ester .The molecular structure of Lasiocarpine (CAS No. 303-34-4) is
.
Lasiocarpine Toxicity Data With Reference
| 1. | sln-dmg-orl 750 ppm | ENMUDM Environmental Mutagenesis. 7 (1985),349. | ||
| 2. | trn-dmg-orl 750 ppm | ENMUDM Environmental Mutagenesis. 7 (1985),349. | ||
| 3. | orl-rat TDLo:255 mg/kg/2Y-C:CAR | NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-39 ,1978. | ||
| 4. | ipr-rat TDLo:470 mg/kg/56W-I:CAR | CNREA8 Cancer Research. 32 (1972),908. | ||
| 5. | orl-rat LD50:110 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 17 (1970),290. | ||
| 6. | ipr-rat LD50:78 mg/kg | CNREA8 Cancer Research. 32 (1972),908. | ||
| 7. | ivn-rat LD50:88 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179. | ||
| 8. | par-rat LD50:80 mg/kg | NATUAS Nature. 223 (1969),1269. | ||
| 9. | ivn-mus LDLo:85 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179. | ||
| 10. | ivn-mky LDLo:20 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 126 (1959),179. |
Lasiocarpine Consensus Reports
IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 , 1976,p. 281.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-39 ,1978. . EPA Genetic Toxicology Program.
Lasiocarpine Safety Profile
Suspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, intraperitoneal, and parenteral routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III
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