Product Name

  • Name

    2-(diethylamino)-4-methylpentyl 4-aminobenzoate, monomethanesulphonate

  • EINECS 205-191-6
  • CAS No. 135-44-4
  • Density g/cm3
  • Solubility
  • Melting Point 171°
  • Formula C17H28N2O2•CH4O3S
  • Boiling Point 417.1°Cat760mmHg
  • Molecular Weight 388.58
  • Flash Point 206°C
  • Transport Information
  • Appearance
  • Safety Poison by subcutaneous, intravenous, and intraspinal routes. Used as a topical and infiltration anesthetic. When heated to decomposition it emits very toxic fumes of SOx and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 135-44-4 (2-(diethylamino)-4-methylpentyl 4-aminobenzoate, monomethanesulphonate)
  • Hazard Symbols
  • Synonyms p-Aminobenzoic acid-N-1-diethylamino-1-isobutylethanol methanesulfonate;S.P. 147;1-Pentanol, 2-(diethylamino)-4-methyl-, p-aminobenzoate (ester), monomethanesulfonate;N,N-Diethylleucinon-p-aminobenzoic acid methanesulfonate;Leucinocaine mesylate;p-Aminobenzoic acid N,N-diethylleucinol ester methanesulfonate;(2-diethylamino-4-methyl-pentyl) 4-aminobenzoate; methanesulfonic acid;p-Aminobenzoic acid beta-diethylaminoisohexyl ester methanesulfonate;2-(Diethylamino)-4-methyl-1-pentanol, p-aminobenzoate ester, methanesulfonate;Methanesulfonic acid, compd. with 2-(diethylamino)-4-methylpentyl P-aminobenzoate (1:1);1-Pentanol,2-(diethylamino)-4-methyl-,4- aminobenzoate (ester),monomethanesulfonate (salt);2-(Diethylamino)-4-methylpentyl 4-aminobenzoate, monomethanesulphonate;2-Methyl-4-diethylaminopentan-5-ol p-aminobenzoate;Panthesin;Panthesine;p-AMINOBENZOIC ACID-N,N-DIETHYLLEUCINOL ESTER METHANESULFONATE;METHANESULFONIC ACID, COMPOUND with 2-(DIETHYLAMINO)-4-METHYLPENTYL PAMINOBENZOATE (1:1);p-AMINOBENZOIC ACID-β-DIETHYLAMINOISOHEXYL ESTER METHANESULFONATE;
  • PSA 118.31000
  • LogP 4.34810

Leucinocaine methanesulfonate Chemical Properties

IUPAC Name: [2-(diethylamino)-4-methylpentyl] 4-aminobenzoate; methanesulfonic acid
Synonyms of Leucinocaine methanesulfonate (CAS NO.135-44-4): 2-(Diethylamino)-4-methyl-1-pentanol, p-aminobenzoate ester, methanesulfonate ; 2-Methyl-4-diethylaminopentan-5-ol p-aminobenzoate ; EINECS 205-191-6 ; Leucinocaine mesylate ; Methanesulfonic acid, compd. with 2-(diethylamino)-4-methylpentyl P-aminobenzoate (1:1) ; N,N-Diethylleucinon-p-aminobenzoic acid methanesulfonate ; Panthesin ; Panthesine ; S.P. 147 ; p-Aminobenzoic acid N,N-diethylleucinol ester ; methanesulfonate ; p-Aminobenzoic acid beta-diethylaminoisohexyl ester methanesulfonate ; p-Aminobenzoic acid-N-1-diethylamino-1-isobutylethanol methanesulfonate ; 1-Pentanol, 2-(diethylamino)-4-methyl-, p-aminobenzoate (ester), monomethanesulfonate
CAS NO: 135-44-4 
Molecular Formula of Leucinocaine methanesulfonate (CAS NO.135-44-4): C18H32N2O5S  
Molecular Weight: 388.5221
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 10
Polar Surface Area: 32.78 Å
Flash Point: 206 °C
Enthalpy of Vaporization of Leucinocaine methanesulfonate (CAS NO.135-44-4): 67.04 kJ/mol
Boiling Point: 417.1 °C at 760 mmHg
Vapour Pressure: 3.65E-07 mmHg at 25°C 
Molecular Structure: 

Leucinocaine methanesulfonate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 20mg/kg (20mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.
guinea pig LDLo subcutaneous 112mg/kg (112mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.
mouse LDLo intravenous 49mg/kg (49mg/kg) BEHAVIORAL: GENERAL ANESTHETIC "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936Vol. -, Pg. -, 1936.
mouse LDLo subcutaneous 300mg/kg (300mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.
rabbit LDLo intraspinal 10200ug/kg (10.2mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 137, 1935.
rabbit LDLo intravenous 20mg/kg (20mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 57, Pg. 221, 1936.
rabbit LDLo subcutaneous 240mg/kg (240mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.

Leucinocaine methanesulfonate Safety Profile

Poison by subcutaneous, intravenous, and intraspinal routes. Used as a topical and infiltration anesthetic. When heated to decomposition it emits very toxic fumes of SOx and NOx.

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