IUPAC Name: [2-(diethylamino)-4-methylpentyl] 4-aminobenzoate; methanesulfonic acid
Synonyms of Leucinocaine methanesulfonate (CAS NO.135-44-4): 2-(Diethylamino)-4-methyl-1-pentanol, p-aminobenzoate ester, methanesulfonate ; 2-Methyl-4-diethylaminopentan-5-ol p-aminobenzoate ; EINECS 205-191-6 ; Leucinocaine mesylate ; Methanesulfonic acid, compd. with 2-(diethylamino)-4-methylpentyl P-aminobenzoate (1:1) ; N,N-Diethylleucinon-p-aminobenzoic acid methanesulfonate ; Panthesin ; Panthesine ; S.P. 147 ; p-Aminobenzoic acid N,N-diethylleucinol ester ; methanesulfonate ; p-Aminobenzoic acid beta-diethylaminoisohexyl ester methanesulfonate ; p-Aminobenzoic acid-N-1-diethylamino-1-isobutylethanol methanesulfonate ; 1-Pentanol, 2-(diethylamino)-4-methyl-, p-aminobenzoate (ester), monomethanesulfonate
CAS NO: 135-44-4
Molecular Formula of Leucinocaine methanesulfonate (CAS NO.135-44-4): C18H32N2O5S
Molecular Weight: 388.5221
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 10
Polar Surface Area: 32.78 Å2
Flash Point: 206 °C
Enthalpy of Vaporization of Leucinocaine methanesulfonate (CAS NO.135-44-4): 67.04 kJ/mol
Boiling Point: 417.1 °C at 760 mmHg
Vapour Pressure: 3.65E-07 mmHg at 25°C
Molecular Structure:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | intravenous | 20mg/kg (20mg/kg) | Physiological Reviews. Vol. 12, Pg. 190, 1932. | |
guinea pig | LDLo | subcutaneous | 112mg/kg (112mg/kg) | Physiological Reviews. Vol. 12, Pg. 190, 1932. | |
mouse | LDLo | intravenous | 49mg/kg (49mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936Vol. -, Pg. -, 1936. |
mouse | LDLo | subcutaneous | 300mg/kg (300mg/kg) | Physiological Reviews. Vol. 12, Pg. 190, 1932. | |
rabbit | LDLo | intraspinal | 10200ug/kg (10.2mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 137, 1935. | |
rabbit | LDLo | intravenous | 20mg/kg (20mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 57, Pg. 221, 1936. | |
rabbit | LDLo | subcutaneous | 240mg/kg (240mg/kg) | Physiological Reviews. Vol. 12, Pg. 190, 1932. |
Poison by subcutaneous, intravenous, and intraspinal routes. Used as a topical and infiltration anesthetic. When heated to decomposition it emits very toxic fumes of SOx and NOx.
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