Lobeline supplier | CasNO.90-69-7

Name
Lobeline
EINECS
CAS No. 90-69-7
Article Data13
CAS DataBase
Density 1.085g/cm3
Solubility
Melting Point 130-131°
Formula C22H27 N O2
Boiling Point 485.6oC at 760 mmHg
Molecular Weight 337.462
Flash Point 247.5oC
Transport Information
Appearance
Safety Poison by intraperitoneal and intravenous routes. Causes stimulation which leads to convulsions in severe cases. Nausea and vomiting are frequent. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes 23/24/25
Molecular Structure
Hazard Symbols T
Synonyms Ethanone,2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, [2R-[2a,6a(S*)]]-; Lobeline (8CI); a-Lobeline (7CI); (-)-Lobeline; (-)-a-Lobeline; 2-[6-(b-Hydroxyphenethyl)-1-methyl-2-piperidyl]acetophenone;8,10-Diphenyllobelionol; Inflatine; L-Lobeline; Lobelin; Lobnico; NIH 11034;l-Lobeline
PSA 40.54000
LogP 4.17390

Synthetic route

: 579-21-5
Lobelanine

: 90-69-7
lobeline

Conditions

Conditions	Yield
With ammonium formate In 1,2-dichloro-ethane at 75℃; for 1h; Inert atmosphere;	91%

: 2-{(6S)-6-[(2S)-2-(tert-butyldimethylsilanoxy)-2-phenylethyl]-1-methylpiperidin-(2R)-2-yl}-1-phenylethanone

: 90-69-7
lobeline

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol at 60℃; for 12h;	90%

: C32H49NO3SSi

: 90-69-7
lobeline

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 0.5h; Large scale;	88%

: (+/-)-Lobelanine hydrochloride

: 90-69-7
lobeline

Conditions

Conditions	Yield
Stage #1: (+/-)-Lobelanine hydrochloride With hydrogen; triethylamine; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine In methanol at 47 - 53℃; under 525.053 - 97584.8 Torr; Industry scale; Stage #2: With hydrogenchloride In water; toluene at 35 - 40℃; for 0.333333h; pH=0.5 - 1.5; Stage #3: With sodium hydroxide In water; toluene at 35 - 40℃; for 0.333333h; pH=12 - 13;	29%

Yield

Stage #1: (+/-)-Lobelanine hydrochloride With hydrogen; triethylamine; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine In methanol at 47 - 53℃; under 525.053 - 97584.8 Torr; Industry scale;
Stage #2: With hydrogenchloride In water; toluene at 35 - 40℃; for 0.333333h; pH=0.5 - 1.5;
Stage #3: With sodium hydroxide In water; toluene at 35 - 40℃; for 0.333333h; pH=12 - 13;

29%

: 134-63-4
Lobeline hydrochloride

A: (2S)-Lobeline

B: 90-69-7
lobeline

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water for 48h;

: 237059-21-1
(2S,6S,2R)-2-<6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl>-1-phenylethan-<1,3>-dioxolane

A: (2S)-Lobeline

B: 90-69-7
lobeline

Conditions

Conditions	Yield
With hydrogenchloride Heating; Yield given; Yields of byproduct given;

: 491837-37-7
(1S)-2-((S)-oxiranyl)-1-phenylethanol

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1.1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / dimethylformamide / 3 h / 20 °C 2.1: CuI / diethyl ether / 0.25 h / -30 °C 2.2: 92 percent / diethyl ether / 0.5 h / -40 °C 3.1: 97 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C 4.1: 88 percent / dimethylformamide; H2O / 20 h / 50 °C 5.1: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C 6.1: tetrahydrofuran / 0 - 20 °C 7.1: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C 8.1: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 9.1: 82 percent / tetrahydrofuran / 13 h / 65 °C 10.1: HCl / propan-2-ol / 3 h / 60 °C View Scheme

Yield

Multi-step reaction with 10 steps
1.1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / dimethylformamide / 3 h / 20 °C
2.1: CuI / diethyl ether / 0.25 h / -30 °C
2.2: 92 percent / diethyl ether / 0.5 h / -40 °C
3.1: 97 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C
4.1: 88 percent / dimethylformamide; H2O / 20 h / 50 °C
5.1: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
6.1: tetrahydrofuran / 0 - 20 °C
7.1: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C
8.1: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C
9.1: 82 percent / tetrahydrofuran / 13 h / 65 °C
10.1: HCl / propan-2-ol / 3 h / 60 °C
View Scheme

: 491837-39-9
(1S,3S)-tert-butyldimethyl(2-oxiranyl-1-phenylethoxy)silane

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1.1: CuI / diethyl ether / 0.25 h / -30 °C 1.2: 92 percent / diethyl ether / 0.5 h / -40 °C 2.1: 97 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C 3.1: 88 percent / dimethylformamide; H2O / 20 h / 50 °C 4.1: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C 5.1: tetrahydrofuran / 0 - 20 °C 6.1: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C 7.1: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 8.1: 82 percent / tetrahydrofuran / 13 h / 65 °C 9.1: HCl / propan-2-ol / 3 h / 60 °C View Scheme

Yield

Multi-step reaction with 9 steps
1.1: CuI / diethyl ether / 0.25 h / -30 °C
1.2: 92 percent / diethyl ether / 0.5 h / -40 °C
2.1: 97 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C
3.1: 88 percent / dimethylformamide; H2O / 20 h / 50 °C
4.1: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
5.1: tetrahydrofuran / 0 - 20 °C
6.1: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C
7.1: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C
8.1: 82 percent / tetrahydrofuran / 13 h / 65 °C
9.1: HCl / propan-2-ol / 3 h / 60 °C
View Scheme

: 491837-38-8
(1S,3S)-4-nitrobenzoic acid 2-oxiranyl-1-phenylethyl ester

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 11 steps 1.1: 77 percent / K2CO3; methanol / H2O / 2 h / 20 °C 2.1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / dimethylformamide / 3 h / 20 °C 3.1: CuI / diethyl ether / 0.25 h / -30 °C 3.2: 92 percent / diethyl ether / 0.5 h / -40 °C 4.1: 97 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C 5.1: 88 percent / dimethylformamide; H2O / 20 h / 50 °C 6.1: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C 7.1: tetrahydrofuran / 0 - 20 °C 8.1: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C 9.1: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 10.1: 82 percent / tetrahydrofuran / 13 h / 65 °C 11.1: HCl / propan-2-ol / 3 h / 60 °C View Scheme

Yield

Multi-step reaction with 11 steps
1.1: 77 percent / K2CO3; methanol / H2O / 2 h / 20 °C
2.1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / dimethylformamide / 3 h / 20 °C
3.1: CuI / diethyl ether / 0.25 h / -30 °C
3.2: 92 percent / diethyl ether / 0.5 h / -40 °C
4.1: 97 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C
5.1: 88 percent / dimethylformamide; H2O / 20 h / 50 °C
6.1: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
7.1: tetrahydrofuran / 0 - 20 °C
8.1: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C
9.1: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C
10.1: 82 percent / tetrahydrofuran / 13 h / 65 °C
11.1: HCl / propan-2-ol / 3 h / 60 °C
View Scheme

: 491837-40-2
(1S,3R)-1-(tert-butyldimethylsilanoxy)-1-phenylhept-6-en-3-ol

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: 97 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C 2: 88 percent / dimethylformamide; H2O / 20 h / 50 °C 3: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C 4: tetrahydrofuran / 0 - 20 °C 5: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C 6: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 7: 82 percent / tetrahydrofuran / 13 h / 65 °C 8: HCl / propan-2-ol / 3 h / 60 °C View Scheme

Yield

Multi-step reaction with 8 steps
1: 97 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C
2: 88 percent / dimethylformamide; H2O / 20 h / 50 °C
3: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
4: tetrahydrofuran / 0 - 20 °C
5: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C
6: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C
7: 82 percent / tetrahydrofuran / 13 h / 65 °C
8: HCl / propan-2-ol / 3 h / 60 °C
View Scheme

: 491837-42-4
(2'S,1S)-{1-[2-(tert-butyldimethylsilanoxy)-2-phenylethyl]pent-4-enyl}methylamine

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C 2: tetrahydrofuran / 0 - 20 °C 3: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C 4: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 5: 82 percent / tetrahydrofuran / 13 h / 65 °C 6: HCl / propan-2-ol / 3 h / 60 °C View Scheme

: 491837-41-3
(2'S,1R)-methanesulfonic acid 1-[2-(tert-butyldimethylsilanoxy)-2-phenylethyl]pent-4-enyl ester

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 88 percent / dimethylformamide; H2O / 20 h / 50 °C 2: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C 3: tetrahydrofuran / 0 - 20 °C 4: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C 5: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 6: 82 percent / tetrahydrofuran / 13 h / 65 °C 7: HCl / propan-2-ol / 3 h / 60 °C View Scheme

Yield

Multi-step reaction with 7 steps
1: 88 percent / dimethylformamide; H2O / 20 h / 50 °C
2: 95 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
3: tetrahydrofuran / 0 - 20 °C
4: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C
5: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C
6: 82 percent / tetrahydrofuran / 13 h / 65 °C
7: HCl / propan-2-ol / 3 h / 60 °C
View Scheme

: 491837-46-8
(2'S,1S)-{1-[2-(tert-butyldimethylsilanoxy)-2-phenylethyl]-5-oxopentyl}methylcarbamic acid tert-butyl ester

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 82 percent / tetrahydrofuran / 13 h / 65 °C 2: HCl / propan-2-ol / 3 h / 60 °C View Scheme

: 491837-43-5
(2'S,1S)-{1-[2-(tert-butyldimethylsilanoxy)-2-phenylethyl]pent-4-enyl}methylcarbamic acid tert-butyl ester

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: tetrahydrofuran / 0 - 20 °C 2: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C 3: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 4: 82 percent / tetrahydrofuran / 13 h / 65 °C 5: HCl / propan-2-ol / 3 h / 60 °C View Scheme

: 491837-44-6
(2'S,1S)-{1-[2-(tert-butyldimethylsilanoxy)-2-phenylethyl]-5-hydroxypentyl}methylcarbamic acid tert-butyl ester

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 2: 82 percent / tetrahydrofuran / 13 h / 65 °C 3: HCl / propan-2-ol / 3 h / 60 °C View Scheme

: {1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-dicyclohexylboranyl-pentyl}-methyl-carbamic acid tert-butyl ester

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 1.83 g / NaOH; H2O2 / H2O; ethanol; tetrahydrofuran / 1 h / 20 °C 2: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C 3: 82 percent / tetrahydrofuran / 13 h / 65 °C 4: HCl / propan-2-ol / 3 h / 60 °C View Scheme

: dehydrolobeline

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 90 percent / p-TsOH / benzene / 4 h / Heating 2: 61 percent / H2 / Pd/C / ethyl acetate / 4 h 3: 0.12 HCl / Heating View Scheme

: 208832-18-2
(2S,6S,2S)-2-<6-(2-hydroxy-2-phenylethyl)-1-methyl-1,2,5,6-tetrahydropyridin-2-yl>-1-phenylethan-<1,3>-dioxolane

: 90-69-7
lobeline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 61 percent / H2 / Pd/C / ethyl acetate / 4 h 2: 0.12 HCl / Heating View Scheme

: 134-63-4
Lobeline hydrochloride

: 90-69-7
lobeline

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; benzene	40 mg

: 552-72-7
NSC 95097

A: (2S)-Lobeline

B: 90-69-7
lobeline

Conditions

Conditions	Yield
With Pd(sparteine)Cl2; 6-methoxy-2-naphthol sodium salt; oxygen; (-)-sparteine In chloroform at 35℃; for 48h; Molecular sieve; optical yield given as %ee;

: 1125824-45-4
[(S)-2-[(2S,6R)-1-methyl-6-(2-oxo-2-phenylethyl)piperidin-2-yl]-1-phenylethyl acetate]

: 90-69-7
lobeline

Conditions

Conditions	Yield
With hydrogenchloride; water In methanol Reflux;	43 mg

: 79-03-8
propionyl chloride

: 90-69-7
lobeline

: 1217313-06-8
cis-LPR hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	96%

: 75-36-5
acetyl chloride

: 90-69-7
lobeline

: 1217888-95-3
cis-LAC hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	93%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 90-69-7
lobeline

: 1217313-11-5
cis-LTH hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	90%

: 98-88-4
benzoyl chloride

: 90-69-7
lobeline

: 1217313-00-2
cis-LBZ hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	90%

: 141-75-3
butyryl chloride

: 90-69-7
lobeline

: 1217313-07-9
cis-LBU hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	90%

: 98-09-9
benzenesulfonyl chloride

: 90-69-7
lobeline

: 1217313-12-6
cis-LBS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	90%

: 93-11-8
2-Naphthalenesulfonyl chloride

: 90-69-7
lobeline

: 1217313-18-2
cis-LINPS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	90%

: 90-69-7
lobeline

: 1939-99-7
benzenesulfonyl chloride

: 1217313-21-7
cis-LBNS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	90%

: 16629-19-9
thiophene-2-sulfonyl chloride

: 90-69-7
lobeline

: 1217313-17-1
cis-LTHS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	88%

: 85-46-1
1-Naphthalenesulfonyl chloride

: 90-69-7
lobeline

: 1217313-22-8
cis-LNPS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	88%

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 90-69-7
lobeline

: 1217313-15-9
cis-LFBS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	86%

: 79-30-1
isobutyryl chloride

: 90-69-7
lobeline

: 1217313-09-1
cis-LIBU hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	86%

: 2386-60-9
perfluoro-1-butanesulfonyl fluoride

: 90-69-7
lobeline

: 1217313-20-6
cis-LBUS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	82%

: 874-60-2
4-methyl-benzoyl chloride

: 90-69-7
lobeline

: 1217313-02-4
cis-LTO hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	80%

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 90-69-7
lobeline

: 1217313-14-8
cis-LCBS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	80%

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 90-69-7
lobeline

: 1217313-16-0
cis-LNBS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	78%

: 10147-37-2
2-propanesulfonyl chloride

: 90-69-7
lobeline

: 1217313-19-3
cis-LIPS hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; Inert atmosphere;	72%

: 1066-30-4
chromium(lll) acetate

: 90-69-7
lobeline

: 579-21-5
Lobelanine

: 7732-18-5
water

: 90-69-7
lobeline

: 98-86-2
acetophenone

Conditions

Conditions	Yield
at 110℃;

: 64-19-7
acetic acid

: 90-69-7
lobeline

sodium amalgam: sodium amalgam

lobelanidine: lobelanidine

Conditions

Conditions	Yield
at 10 - 15℃;

...Expand

Lobeline Chemical Properties

Molecular Structure of Lobeline (CAS NO.90-69-7):

IUPAC Name: 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone
Empirical Formula: C₂₂H₂₇NO₂
Molecular Weight: 337.4553
Index of Refraction: 1.562
Surface Tension: 41.8 dyne/cm
Density: 1.085 g/cm³
Flash Point: 247.5 °C
Enthalpy of Vaporization: 79.11 kJ/mol
Boiling Point: 485.6 °C at 760 mmHg
Vapour Pressure: 3.05E-10 mmHg at 25°C
Synonyms of Lobeline (CAS NO.90-69-7): L-lobeline free base ; Lobeline;LOBELIDINE95%,98% ; LOBELINE HCl, a-(P) ; Lobeline (base and/or unspecified salts) ; (-)-α-[(2R,6S)-6-[(S)-β-hydroxyphenethyl]-1-methyl-2-piperidinyl] ; acetophenone ; Inflatine ; Lobelin

Lobeline Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	43500ug/kg (43.5mg/kg)		Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse	LD50	intravenous	6300ug/kg (6.3mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 103, Pg. 146, 1955.
mouse	LDLo	subcutaneous	100mg/kg (100mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 132, Pg. 63, 1928.
rabbit	LD50	subcutaneous	35mg/kg (35mg/kg)		Farmakologiya i Toksikologiya Vol. 4(1), Pg. 34, 1941.
rabbit	LDLo	intravenous	10mg/kg (10mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 31, Pg. 43, 1927.
rat	LDLo	subcutaneous	80mg/kg (80mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 132, Pg. 63, 1928.

Lobeline Safety Profile

Poison by intraperitoneal and intravenous routes. Causes stimulation which leads to convulsions in severe cases. Nausea and vomiting are frequent. When heated to decomposition it emits toxic fumes of NO_x.

Lobeline Specification

Lobeline (CAS NO.90-69-7) is a highly-toxic material,Iis pure form is a white amorphous powder which is freely soluble in water.burning will produce nitrogen oxides emitted toxic fumes.Besides should be stored and transported in low-temperature,drying environment. separately with oxidizing agents.Fire extinguishing agents water, carbon dioxide, dry powder, foam would be used if emergency.

Lobeline (CAS NO.90-69-7) has been used as a smoking cessation aid, and may have application in the treatment of other drug addictions such as addiction to amphetamines, cocaine or alcohol..Lobeline has multiple mechanisms of action, acting as a VMAT2 ligand, which stimulates dopamine release to a moderate extent when administered alone, but reduces the dopamine release caused by methamphetamine. It also inhibits the reuptake of dopamine and serotonin, and acts as a mixed agonist-antagonist at nicotinic acetylcholine receptors and an antagonist at μ-opioid receptors.

Product Name

Lobeline

Synthetic route

Lobeline Chemical Properties

Lobeline Toxicity Data With Reference

Lobeline Safety Profile

Lobeline Specification

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