Product Name

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  • Name

    LORMETAZEPAM

  • EINECS
  • CAS No. 848-75-9
  • Density 1.44 g/cm3
  • Solubility
  • Melting Point 163-168ºC
  • Formula C16H12 Cl2 N2 O2
  • Boiling Point 575.8ºC at 760mmHg
  • Molecular Weight 335.189
  • Flash Point 302.1ºC
  • Transport Information
  • Appearance
  • Safety Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985).
  • Risk Codes 11-23/24/25-39/23/24/25-22
  • Molecular Structure Molecular Structure of 848-75-9 (LORMETAZEPAM)
  • Hazard Symbols F,T
  • Synonyms 2H-1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- (7CI,8CI);(RS)-Lormetazepam; (?à)-Lormetazepam;7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one;Ergocalm; Loramet; Lormetazepam; Methyllorazepam; N-Methyllorazepam; Noctamid;Noctamide; Ro 5-5516; WY 4082
  • PSA 52.90000
  • LogP 2.62620

Lormetazepam Chemical Properties

Product Name: Lormetazepam (CAS NO.848-75-9)


Molecular Formula: C16H12Cl2N2O2
Molecular Weight: 335.18g/mol
Mol File: 848-75-9.mol
EINECS: 212-700-5
Boiling point: 575.8 °C at 760 mmHg
Flash Point: 302.1 °C
Density: 1.44 g/cm3
Surface Tension: 51.6 dyne/cm
Enthalpy of Vaporization: 90.72 kJ/mol
Vapour Pressure: 4.23E-14 mmHg at 25°C
XLogP3-AA: 2.4
H-Bond Donor: 1
H-Bond Acceptor: 3
Structure Descriptors of Lormetazepam (CAS NO.848-75-9):
  IUPAC Name: 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
  Canonical SMILES: CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl
  InChI: InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3 
  InChIKey: FJIKWRGCXUCUIG-UHFFFAOYSA-N

Lormetazepam Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 780mg/kg (780mg/kg) BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
mouse LD50 oral 1790mg/kg (1790mg/kg) BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 intraperitoneal 6250mg/kg (6250mg/kg) BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 oral > 10gm/kg (10000mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: SLEEP

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 subcutaneous > 10gm/kg (10000mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: SLEEP

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,

Lormetazepam Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985).

Lormetazepam Specification

 Lormetazepam , its CAS NO. is 848-75-9, the synonyms are 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- ; 5-25-02-00251 (Beilstein Handbook Reference) ; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one ; 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one ; BRN 0759821 ; EINECS 212-700-5 ; Lormetazepamum ; Methyllorazepam ; N-Methyllorazepam ; Ro 5-5516 ; UNII-GU56C842ZA ; WY 4082 .

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