-
Name
LOXIGLUMIDE
- EINECS
- CAS No. 107097-80-3
- Density 1.233g/cm3
- Solubility
- Melting Point 113-115℃
- Formula C21H30 Cl2 N2 O5
- Boiling Point 632.2°Cat760mmHg
- Molecular Weight 461.386
- Flash Point 336.1°C
- Transport Information
- Appearance
- Safety A poison by intravenous. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx and Cl−.
- Risk Codes 22
-
Molecular Structure
- Hazard Symbols Moderately toxic by ingestion.
- Synonyms Pentanoicacid, 4-[(3,4-dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxo-, (?à)-; CR 1505; Loxiglumide
- PSA 95.94000
- LogP 4.40280
Loxiglumide Chemical Properties
Molecular Structure of Loxiglumide (CAS NO.107097-80-3):
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IUPAC Name: 4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
Empirical Formula: C21H30Cl2N2O5
Molecular Weight: 461.3793
Index of Refraction: 1.537
Surface Tension: 46.9 dyne/cm
Density: 1.233 g/cm3
Flash Point: 336.1 °C
Enthalpy of Vaporization: 98.25 kJ/mol
Boiling Point: 632.2 °C at 760 mmHg
Vapour Pressure: 7.51E-17 mmHg at 25°C
Classification Code :Drug / Therapeutic Agent ; Hormone antagonists ; Hormones, Hormone Substitutes, and Hormone Antagonists
Synonyms of Loxiglumide (CAS NO.107097-80-3): Loxiglumide ; (+-)-4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5-oxope;(+-)--5-oxo;anoicacid;cr1505 ; d,l-4-(3,4-dichlorobenzoylamino)-5-(n-3-methoxypropylpentylamino)-5-oxo-pent ; ntanoicacid ; pentanoicacid,4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)
Loxiglumide Toxicity Data With Reference
| 1. | orl-mus LD50:460 mg/kg | JSONAU Journal of Surgical Oncology. 53 (1993),47. | ||
| 2. | ipr-mus LD50:450 mg/kg | JSONAU Journal of Surgical Oncology. 53 (1993),47. | ||
| 3. | scu-mus LD50:500 mg/kg | JSONAU Journal of Surgical Oncology. 53 (1993),47. | ||
| 4. | ivn-mus LD50:396 mg/kg | USXXAM United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4769389 . |
Loxiglumide Safety Profile
A poison by intravenous. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx and Cl−.
Loxiglumide Specification
The product methods of Loxiglumide (CAS NO.107097-80-3) is by condensation of N-(3,4-dichlorobenzoyl)-glutamic acid anhydride (I) with N-(3-methoxypropyl)-N-pentylamine (II) in water at 5 C.
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