Product Name

  • Name

    lymecycline

  • EINECS 213-592-2
  • CAS No. 992-21-2
  • Density 1.53
  • Solubility
  • Melting Point 192.5°C
  • Formula C29H38 N4 O10
  • Boiling Point 840.5°C at 760 mmHg
  • Molecular Weight 602.642
  • Flash Point 462.1°C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous route. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 992-21-2 (lymecycline)
  • Hazard Symbols
  • Synonyms L-Lysine,N6-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-,[4S-(4a,4aa,5aa,6b,12aa)]-;Lysine,N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-(7CI);Lysine,N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-,L- (8CI);(+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide;2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,lysinemethylene deriv.;Armyl;Ciclisin;Ciclolysal;Ciclolysine;Infaciclina;Lisinbiotic;Lisinciclina;Lymecycline;Mucomycin;N-Lysinomethyltetracycline;N2-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline;N6-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine;Tertamyl;Tetracycline-L-methylenelysine;Tetracyclinemethylenelysine;Tetralisal;Tetralysal;Tetramyl;Vebicyclysal;
  • PSA 242.98000
  • LogP 1.02790

Lymecycline Toxicity Data With Reference

1.    

ivn-mus LD50:181 mg/kg

     KPJBAR    Kalikasan. The Philippine Journal of Biology. 2 (1970),333.

Lymecycline Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic fumes of NOx.

Lymecycline Specification

1. Introduction of Lymecycline
Lymecycline is one kind of solid. The IUPAC Name of this chemical is 2-[[[(Z)-[(4aS,6S,12aS)-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-4,4a,5,5a-tetrahydrotetracen-2-ylidene]-hydroxy-methyl]amino]methylamino]-6-amino-hexanoic acid. Besides, Lymecycline belongs to Antibacterial;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds. In addition, its Classification Code is Anti-Bacterial Agents; Anti-Infective Agents; Drug / Therapeutic Agent. Lymecycline can soluble (at all physiological pH values).

2. Properties of Lymecycline
Physical properties about Lymecycline are:
(1)Index of Refraction: 1.693; (2)Surface Tension: 91.5 dyne/cm; (3)Density: 1.53 g/cm3; (4)Flash Point: 462.1 °C; (5)Enthalpy of Vaporization: 128.01 kJ/mol; (6)Boiling Point: 840.5 °C at 760 mmHg; (7)Vapour Pressure: 5.37E-30 mmHg at 25°C.

3. Structure Descriptors of Lymecycline
(1)InChI: InChI=1S/C29H38N4O10/c1-28(42)13-7-6-9-17(34)18(13)22(35)19-14(28)11-15-21(33(2)3)23(36)20(25(38)29(15,43)24(19)37)26(39)32-12-31-10-5-4-8-16(30)27(40)41/h6-7,9,14-16,21,31,34,36-37,42-43H,4-5,8,10-12,30H2,1-3H3,(H,32,39)(H,40,41)/t14?,15-,16-,21-,28+,29-/m0/s1
(2)InChIKey InChIKey=AHEVKYYGXVEWNO-CCZWQWCCSA-N
(3)Smiles: C1[C@@H]2[C@@](C(=C3C(c4c(cccc4[C@@]([C@@H]13)(C)O)O)=O)O)(C(C(C(NCNCCCC[C@H](N)C(O)=O)=O)=C([C@H]2N(C)C)O)=O)O

4. Toxicity of Lymecycline

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 253mg/kg (253mg/kg)   British Medical Journal. Vol. 2, Pg. 106, 1964.
mouse LD50 intravenous 181mg/kg (181mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 333, 1970.

5. Physical Properties of Lymecycline

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -3.220 (none)   EST
Atmospheric OH Rate Constant 4.11E-10 cm3/molecule-sec 25 EST

6. Uses of Lymecycline
Labelled Lymecycline is a semi-synthetic antibiotic related to Tetracycline (T291400). It is used as antibacterial. In other words, Lymecycline is a tetracycline broad-spectrum antibiotic.

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