• Name

  diphenylpyraline

• EINECS 205-686-7
• CAS No. 147-20-6
• Article Data6
• CAS DataBase
• Density 1.08 g/cm³
• Solubility
• Melting Point
• Formula C19H23 N O
• Boiling Point 378.7 °C at 760 mmHg
• Molecular Weight 281.398
• Flash Point 111.6 °C
• Transport Information
• Appearance
• Safety Poison by ingestion and intravenous routes. An eye irritant. When heated to decomposition it emits toxic fumes of NO_x.
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 1-Methyl-4-piperidylbenzhydryl ether; 4-(Benzhydryloxy)-1-methylpiperidine; AN 1041;Diphenpyraline; Diphenylpyraline; Diphenylpyrilene; Hystryl; Lyssipoll;Mepiben; N-Methyl-4-(benzhydryloxy)piperidine; Neargal; P 253
• PSA 12.47000
• LogP 3.82470

Synthetic route

106-52-5

N-methyl-4-hydroxypiperidine

90-99-3

diphenylchloromethane

147-20-6

diphenylpyraline

Conditions

Conditions	Yield
With tributyl-amine; 4-methyl-2-pentanone

106-52-5

N-methyl-4-hydroxypiperidine

776-74-9

Bromodiphenylmethane

147-20-6

diphenylpyraline

Conditions

Conditions	Yield
With benzene Erhitzen des Reaktionsprodukts auf ca. 150grad;
With tributyl-amine; 4-methyl-2-pentanone

106-52-5

N-methyl-4-hydroxypiperidine

908093-98-1

diazodiphenylmethane

147-20-6

diphenylpyraline

Conditions

Conditions	Yield
With benzene

5382-16-1

4-HYDROXYPIPERIDINE

147-20-6

diphenylpyraline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 40 °C 2: toluene-4-sulfonic acid / N,N-dimethyl-formamide; toluene / Reflux; Dean-Stark View Scheme

106-52-5

N-methyl-4-hydroxypiperidine

91-01-0

1,1-Diphenylmethanol

147-20-6

diphenylpyraline

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; toluene Reflux; Dean-Stark;

147-20-6

diphenylpyraline

541-41-3

chloroformic acid ethyl ester

65214-84-8

ethyl 4-(diphenylmethoxy)-1-piperidinecarboxylate

Conditions

Conditions	Yield
In toluene for 5.5h; Heating;	87%

147-20-6

diphenylpyraline

58258-01-8

4-diphenylmethoxypiperidine

Conditions

Conditions	Yield
With ethanol; sodium perchlorate; water for 12h; Reagent/catalyst; Electrochemical reaction; Green chemistry;	44%
Multi-step reaction with 2 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating View Scheme

147-20-6

diphenylpyraline

125602-76-8

ethyl 4-(4-benzhydryloxypiperidino)butanoate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: K2CO3 / dimethylformamide / 80 °C View Scheme

147-20-6

diphenylpyraline

133993-23-4

4-(4-Benzhydryloxy-piperidin-1-yl)-butyric acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: K2CO3 / dimethylformamide / 80 °C 4: 2N aq. NaOH / methanol / Heating View Scheme

147-20-6

diphenylpyraline

133015-42-6

ethyl <(4-diphenylmethoxy)piperidino>acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: 70 percent / K2CO3 / dimethylformamide / 2 h / 80 °C View Scheme

147-20-6

diphenylpyraline

<4-(diphenylmethoxy)piperidino>acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: 70 percent / K2CO3 / dimethylformamide / 2 h / 80 °C 4: 2N aq. NaOH / methanol / 1 h / Heating View Scheme

147-20-6

diphenylpyraline

4-(diphenylmethoxy)-1-piperidinepropionic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: K2CO3 / dimethylformamide / 80 °C 4: 2N aq. NaOH / methanol / Heating View Scheme

147-20-6

diphenylpyraline

5-(4-Benzhydryloxy-piperidin-1-yl)-pentanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: K2CO3 / dimethylformamide / 80 °C 4: 2N aq. NaOH / methanol / Heating View Scheme

147-20-6

diphenylpyraline

6-(4-Benzhydryloxy-piperidin-1-yl)-hexanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: K2CO3 / dimethylformamide / 80 °C 4: 2N aq. NaOH / methanol / Heating View Scheme

147-20-6

diphenylpyraline

133016-99-6

ethyl 3-[4-(diphenylmethoxy)piperidin-1-yl]propanoate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: K2CO3 / dimethylformamide / 80 °C View Scheme

147-20-6

diphenylpyraline

661481-71-6

5-(4-Benzhydryloxy-piperidin-1-yl)-pentanoic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: K2CO3 / dimethylformamide / 80 °C View Scheme

147-20-6

diphenylpyraline

770685-45-5

6-(4-Benzhydryloxy-piperidin-1-yl)-hexanoic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 87 percent / toluene / 5.5 h / Heating 2: 88 percent / 40percent aq. NaOH / ethanol / 16.5 h / Heating 3: K2CO3 / dimethylformamide / 80 °C View Scheme

Lyssipoll Chemical Properties

Lyssipoll Toxicity Data With Reference

Lyssipoll Safety Profile