Product Name

  • Name

    MEDROXYPROGESTERONE

  • EINECS
  • CAS No. 520-85-4
  • Density 1.13g/cm3
  • Solubility
  • Melting Point 204-206°C
  • Formula C22H32 O3
  • Boiling Point 488°Cat760mmHg
  • Molecular Weight 344.494
  • Flash Point 263°C
  • Transport Information
  • Appearance
  • Safety An experimental teratogen. Experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Risk Codes 48-63-68
  • Molecular Structure Molecular Structure of 520-85-4 (MEDROXYPROGESTERONE)
  • Hazard Symbols Xn
  • Synonyms Pregn-4-ene-3,20-dione,17-hydroxy-6a-methyl-(7CI,8CI); Progesterone, 17-hydroxy-6a-methyl- (6CI); 17-Hydroxy-6a-methylpregn-4-ene-3,20-dione;17-Hydroxy-6a-methylprogesterone;17a-Hydroxy-6a-methylprogesterone; 6a-Methyl-17-hydroxyprogesterone; 6a-Methyl-17R-hydroxyprogesterone;6a-Methyl-17a-hydroxypregn-4-ene-3,20-dione; 6a-Methyl-17a-hydroxyprogesterone; 6a-Methyl-4-pregnen-17a-ol-3,20-dione;Medoxyprogesterone; Medroxyprogesteron; Medroxyprogesterone; NSC 27408; U 8840
  • PSA 54.37000
  • LogP 4.08440

Synthetic route

Medroxyprogesterone acetate
71-58-9

Medroxyprogesterone acetate

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
With potassium hydroxide
With water; sodium hydroxide In methanol for 5h; Reflux;
17-hydroxy-6β-methyl-pregn-4-ene-3,20-dione
80996-18-5

17-hydroxy-6β-methyl-pregn-4-ene-3,20-dione

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
With hydrogenchloride; chloroform
5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione
23706-51-6

5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
With hydrogenchloride; chloroform
With hydrogenchloride
Multi-step reaction with 2 steps
1: pyridine; aq. NaOH solution
2: HCl; CHCl3
View Scheme
16β-bromo-17-hydroxy-6α-methyl-pregn-4-ene-3,20-dione
115459-59-1

16β-bromo-17-hydroxy-6α-methyl-pregn-4-ene-3,20-dione

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
With methanol; nickel
3β-acetoxy-17α-hydroxy-5-pregnen-20-one
1863-39-4

3β-acetoxy-17α-hydroxy-5-pregnen-20-one

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: benzene; toluene-4-sulfonic acid
2: peroxybenzoic acid; chloroform
3: benzene; diethyl ether
4: aqueous methanol.H2SO4
5: CrO3; pyridine
6: aqueous HCl
View Scheme
3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one
113665-92-2

3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CrO3; pyridine
2: aqueous HCl
View Scheme
20,20-ethanediyldioxy-6β-methyl-5α-pregnane-3β,5,17-triol
19699-76-4

20,20-ethanediyldioxy-6β-methyl-5α-pregnane-3β,5,17-triol

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aqueous methanol.H2SO4
2: CrO3; pyridine
3: aqueous HCl
View Scheme
3β-acetoxy-20,20-ethanediyldioxy-pregn-5-en-17-ol
19699-74-2

3β-acetoxy-20,20-ethanediyldioxy-pregn-5-en-17-ol

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: peroxybenzoic acid; chloroform
2: benzene; diethyl ether
3: aqueous methanol.H2SO4
4: CrO3; pyridine
5: aqueous HCl
View Scheme
3β-acetoxy-20,20-ethanediyldioxy-5,6α-epoxy-5α-pregnan-17-ol
19699-75-3

3β-acetoxy-20,20-ethanediyldioxy-5,6α-epoxy-5α-pregnan-17-ol

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzene; diethyl ether
2: aqueous methanol.H2SO4
3: CrO3; pyridine
4: aqueous HCl
View Scheme
3β-acetoxy-5,6α-epoxy-17ξ-((Ξ)-tetrahydropyran-2-yloxy)-5α-androstane-17ξ-carbonitrile
103050-56-2

3β-acetoxy-5,6α-epoxy-17ξ-((Ξ)-tetrahydropyran-2-yloxy)-5α-androstane-17ξ-carbonitrile

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: anisole; diethyl ether
2: CrO3; pyridine
3: aqueous HCl
View Scheme
6-methylpregn-5-ene-3β,17α-diol-20-one diacetate
60446-57-3

6-methylpregn-5-ene-3β,17α-diol-20-one diacetate

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aqueous methanol. HCl
2: cyclohexanone; aluminium isopropylate; toluene
3: aqueous methanol.KOH
View Scheme
6-methylpregn-5-ene-3β,17α-diol-20-one 17-acetate
2381-48-8

6-methylpregn-5-ene-3β,17α-diol-20-one 17-acetate

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: cyclohexanone; aluminium isopropylate; toluene
2: aqueous methanol.KOH
View Scheme
16α,17-epoxy-6α-methyl-pregn-4-ene-3,20-dione
95171-57-6

16α,17-epoxy-6α-methyl-pregn-4-ene-3,20-dione

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; acetic acid; HBr
2: Raney nickel; methanol
View Scheme
3,3;20,20-bis-ethanediyldioxy-6β-methyl-5α-pregnane-5,17-diol
3386-01-4

3,3;20,20-bis-ethanediyldioxy-6β-methyl-5α-pregnane-5,17-diol

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetone / saure Hydrolyse
2: HCl; CHCl3
View Scheme
Multi-step reaction with 3 steps
1: acetone / saure Hydrolyse
2: pyridine; aq. NaOH solution
3: HCl; CHCl3
View Scheme
17-hydroxy-5-pregnene-3,20-dione 3,20-bisethylene ketal
3386-00-3

17-hydroxy-5-pregnene-3,20-dione 3,20-bisethylene ketal

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: peroxyacetic acid
2: tetrahydrofuran
3: acetone / saure Hydrolyse
4: HCl; CHCl3
View Scheme
Multi-step reaction with 5 steps
1: peroxyacetic acid
2: tetrahydrofuran
3: acetone / saure Hydrolyse
4: pyridine; aq. NaOH solution
5: HCl; CHCl3
View Scheme
3,3;20,20-bis-ethanediyldioxy-5,6α-epoxy-5α-pregnan-17-ol
3496-78-4

3,3;20,20-bis-ethanediyldioxy-5,6α-epoxy-5α-pregnan-17-ol

Medroxyprogesterone
520-85-4

Medroxyprogesterone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran
2: acetone / saure Hydrolyse
3: HCl; CHCl3
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran
2: acetone / saure Hydrolyse
3: pyridine; aq. NaOH solution
4: HCl; CHCl3
View Scheme
phenylacetic acid
103-82-2

phenylacetic acid

Medroxyprogesterone
520-85-4

Medroxyprogesterone

6α-methyl-17-phenylacetoxy-pregn-4-ene-3,20-dione
103277-21-0

6α-methyl-17-phenylacetoxy-pregn-4-ene-3,20-dione

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Medroxyprogesterone
520-85-4

Medroxyprogesterone

17-(3-cyclopentyl-propionyloxy)-6α-methyl-pregn-4-ene-3,20-dione
106655-50-9

17-(3-cyclopentyl-propionyloxy)-6α-methyl-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
With trifluoroacetic anhydride
Medroxyprogesterone
520-85-4

Medroxyprogesterone

megestrol
3562-63-8

megestrol

Conditions
ConditionsYield
With chloranil
Medroxyprogesterone
520-85-4

Medroxyprogesterone

21-acetoxy-17-hydroxy-6α-methyl-pregn-4-ene-3,20-dione
3386-03-6

21-acetoxy-17-hydroxy-6α-methyl-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
With peroxide containing THF; iodine; calcium oxide Reagens 4:Methanol; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton;
With 1,4-dioxane; iodine; calcium oxide Reagens 4:Methanol; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton;
Medroxyprogesterone
520-85-4

Medroxyprogesterone

17-acetoxy-21-fluoro-6-methyl-pregna-4,6-diene-3,20-dione
3185-05-5

17-acetoxy-21-fluoro-6-methyl-pregna-4,6-diene-3,20-dione

Medroxyprogesterone
520-85-4

Medroxyprogesterone

6-methyl-3,17-bis-propionyloxy-pregna-3,5-dien-20-one
20980-67-0

6-methyl-3,17-bis-propionyloxy-pregna-3,5-dien-20-one

Conditions
ConditionsYield
/BRN= 3183816/;
Medroxyprogesterone
520-85-4

Medroxyprogesterone

acetic anhydride
108-24-7

acetic anhydride

Medroxyprogesterone acetate
71-58-9

Medroxyprogesterone acetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid; acetic acid
Medroxyprogesterone
520-85-4

Medroxyprogesterone

acetic anhydride
108-24-7

acetic anhydride

3,17-diacetoxy-6-methyl-pregna-3,5-dien-20-one
986-96-9

3,17-diacetoxy-6-methyl-pregna-3,5-dien-20-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid; acetic acid
With toluene-4-sulfonic acid
Medroxyprogesterone
520-85-4

Medroxyprogesterone

acetic anhydride
108-24-7

acetic anhydride

3,17,20-triacetoxy-6-methyl-pregna-3,5,20-triene
103330-21-8

3,17,20-triacetoxy-6-methyl-pregna-3,5,20-triene

Conditions
ConditionsYield
With Isopropenyl acetate; toluene-4-sulfonic acid
Medroxyprogesterone
520-85-4

Medroxyprogesterone

propionic acid
802294-64-0

propionic acid

6α-methyl-17-propionyloxy-pregn-4-ene-3,20-dione
52358-60-8

6α-methyl-17-propionyloxy-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
With trifluoroacetic anhydride
Medroxyprogesterone
520-85-4

Medroxyprogesterone

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

17α-Hydroxy-3-methoxy-6-methyl-pregna-3,5-dien-20-on
979-61-3

17α-Hydroxy-3-methoxy-6-methyl-pregna-3,5-dien-20-on

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol; N,N-dimethyl-formamide
Medroxyprogesterone
520-85-4

Medroxyprogesterone

Megestrol acetate
595-33-5

Megestrol acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; toluene-4-sulfonic acid
2: tetrachloro-<1,4>benzoquinone
View Scheme
Medroxyprogesterone
520-85-4

Medroxyprogesterone

17-acetoxy-6α-methyl-pregna-1,4-diene-3,20-dione
151-68-8

17-acetoxy-6α-methyl-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; toluene-4-sulfonic acid
2: SeO2; pyridine; tert-butyl alcohol
View Scheme
Medroxyprogesterone
520-85-4

Medroxyprogesterone

17-acetoxy-6-methyl-pregna-1,4,6-triene-3,20-dione
982-89-8

17-acetoxy-6-methyl-pregna-1,4,6-triene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; toluene-4-sulfonic acid
2: tetrachloro-<1,4>benzoquinone
3: SeO2; pyridine; tert-butyl alcohol
View Scheme
Medroxyprogesterone
520-85-4

Medroxyprogesterone

17,21-diacetoxy-6-methyl-pregna-4,6-diene-3,20-dione
87977-69-3

17,21-diacetoxy-6-methyl-pregna-4,6-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iodine; CaO; dioxane / Reagens 4:Methanol; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton
2: acetic acid; toluene-4-sulfonic acid / bei Siedetemperatur
3: tetrachloro-<1,4>benzoquinone; tert-butyl alcohol
View Scheme
Medroxyprogesterone
520-85-4

Medroxyprogesterone

17,21-diacetoxy-6α-methyl-pregn-4-ene-3,20-dione
2287-55-0

17,21-diacetoxy-6α-methyl-pregn-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iodine; CaO; peroxide containing THF / Reagens 4:Methanol; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton
2: acetic acid; toluene-4-sulfonic acid / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: iodine; CaO; dioxane / Reagens 4:Methanol; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton
2: acetic acid; toluene-4-sulfonic acid / bei Siedetemperatur
View Scheme

MEDROXYPROGESTERONE Chemical Properties

Product Name: Medroxyprogesterone (CAS NO.520-85-4)


Molecular Formula: C22H32O3
Molecular Weight: 344.49g/mol
Mol File: 520-85-4.mol
Einecs: 208-298-6
Boiling point: 488 °C at 760 mmHg
Flash Point: 263 °C
Density: 1.13 g/cm3
Surface Tension: 45.1 dyne/cm
Enthalpy of Vaporization: 86.88 kJ/mol
Vapour Pressure: 1.43E-11 mmHg at 25°C
XLogP3-AA: 3.5
H-Bond Donor: 1
H-Bond Acceptor: 3

MEDROXYPROGESTERONE Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo parenteral 6mg/kg/13W-I (6mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Medical Journal of Australia. Vol. 163, Pg. 51, 1995.

MEDROXYPROGESTERONE Safety Profile

An experimental teratogen. Experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Medroxyprogesterone (CAS NO.520-85-4):
Hazard Codes: Xn
Risk Statements: 48-63-68 
48:  Danger of serious damage to health by prolonged exposure
63:  Possible risk of harm to the unborn child
68:  Possible risk of irreversible effects
Safety Statements: 22-24/25
22:  Do not breathe dust  
24:  Avoid contact with skin 
25:  Avoid contact with eyes 

MEDROXYPROGESTERONE Specification

 Medroxyprogesterone ,its CAS NO. is 520-85-4,the synonyms is Methyloxyprogesterone ; Hydroxymethylprogesterone ; 17Alpha-hydroxy-6alpha-methyl-4-pregnene-3,20-dione ; 17Alpha-hydroxy-6alpha-methylprogesterone ; 6-Dihydromegestrol ; 6Alpha-methyl-17alpha-hydroxy-progesterone ; 6-Alpha-methyl-17-hydroprogesterone .

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View