-
Name
Mannosulfan
- EINECS
- CAS No. 7518-35-6
- Density 1.65g/cm3
- Solubility
- Melting Point 114.5°C
- Formula C10H22 O14 S4
- Boiling Point 873.8°C at 760 mmHg
- Molecular Weight 494.54
- Flash Point 482.3°C
- Transport Information
- Appearance
- Safety Moderately toxic by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx. See also SULFONATES.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Mannitol,1,2,5,6-tetramethanesulfonate (7CI);Mannitol, 1,2,5,6-tetramethanesulfonate,D- (8CI);1,2,5,6-Tetra-O-mesyl-D-mannitol;1,2,5,6-Tetra-O-methylsulfonyl-D-mannitol;1,2,5,6-Tetrakis(methylsulfonyl)-D-mannitol;1,2,5,6-Tetramesyl-D-mannitol;1,2,5,6-Tetramethanesulfonyl-D-mannitol;Mannosulfan;R 52 (antitumoragent);TMSM;Zitostop;
- PSA 247.46000
- LogP 0.67340
Mannosulfan Chemical Properties
IUPAC Name: [(2R,3S,4S,5R)-3,4-Dihydroxy-2,5,6-tris(methylsulfonyloxy)hexyl]methanesulfonate
Empirical Formula of Mannosulfan (CAS NO.7518-35-6): C10H22O14S4
Molecular Weight: 494.5333 g/mol
Index of Refraction: 1.536
Density: 1.65 g/cm3
Flash Point: 482.3 °C
Enthalpy of Vaporization: 144.28 kJ/mol
Boiling Point: 873.8 °C at 760 mmHg
Structure of Mannosulfan (CAS NO.7518-35-6):
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Mannosulfan Uses
Mannosulfan (CAS NO.7518-35-6) is an alkylating agent used in the treatment of cancer.
Mannosulfan Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1730mg/kg (1730mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 961, 1973. | |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 961, 1973. | |
| mouse | LD50 | unreported | 2300mg/kg (2300mg/kg) | Therapia Hungarica. Vol. 19, Pg. 10, 1971. | |
| rat | LD50 | intraperitoneal | 2300mg/kg (2300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 961, 1973. | |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 961, 1973. | |
| rat | LD50 | unreported | 2gm/kg (2000mg/kg) | Therapia Hungarica. Vol. 19, Pg. 10, 1971. |
Mannosulfan Safety Profile
Moderately toxic by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx. See also SULFONATES.
Mannosulfan Specification
Mannosulfan , its cas register number is 7518-35-6. It also can be called 1,2,5,6-Tetramesyl-D-mannitol ; Tetra-o-methyl-sulphonyl-D-mannitol ; and D-Mannitol 1,2,5,6-tetramethanesulfonate .
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