Product Name

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  • Name

    7-chloro-2,3-dihydro-1-methyl-5-phenyl-1H-benzo-1,4-diazepine monohydrochloride

  • EINECS
  • CAS No. 2898-11-5
  • Density 1.18g/cm3
  • Solubility
  • Melting Point 259-260 °C
  • Formula C16H15 Cl N2 . Cl H
  • Boiling Point 404.4°Cat760mmHg
  • Molecular Weight 307.24
  • Flash Point 198.4°C
  • Transport Information
  • Appearance
  • Safety Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 2898-11-5 (7-chloro-2,3-dihydro-1-methyl-5-phenyl-1H-benzo-1,4-diazepine monohydrochloride)
  • Hazard Symbols
  • Synonyms 1H-1,4-Benzodiazepine,7-chloro-2,3-dihydro-1-methyl-5-phenyl-, monohydrochloride (8CI,9CI);7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine hydrochloride;Ansius; Diepin; Elbrus; Esmail; Medazepam hydrochloride; Medazepol; Megasedan;Mezepan; RB 252; Ro 5-4556; S 804
  • PSA 15.60000
  • LogP 3.92980

Medazepam hydrochloride Chemical Properties

Molecular Structure of  Medazepam hydrochloride (CAS NO.2898-11-5):

IUPAC Name: 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine hydrochloride
Empirical Formula: C16H15ClN2 
Molecular Weight: 270.7567 
Index of Refraction: 1.617 
Surface Tension: 42.2 dyne/cm
Density: 1.18 g/cm3 
Flash Point: 198.4 °C 
Enthalpy of Vaporization: 65.58 kJ/mol 
Boiling Point: 404.4 °C at 760 mmHg 
Vapour Pressure: 9.49E-07 mmHg at 25°C 
Synonyms of Medazepam hydrochloride (CAS NO.2898-11-5): 7-chloro-2,3-dihydro-1-methyl-5-phenyl-1H-benzo-1,4-diazepine monohydrochloride ; 1H-1,4-Benzodiazepine, 7-chloro-2,3-dihydro-1-methyl-5-phenyl-, monohydrochloride ; Diepin ; Medazepam HCl ; Medazepam hydrochloride ; Ro 5-4556

Medazepam hydrochloride Toxicity Data With Reference

1.    

orl-rat LD50:900 mg/kg

     TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
2.    

ipr-rat LD50:210 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1542.
3.    

scu-rat LD50:1700 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1542.
4.    

ivn-rat LD50:91 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),833.
5.    

orl-mus LD50:710 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1542.
6.    

ipr-mus LD50:314 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),833.
7.    

scu-mus LD50:720 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1542.
8.    

ivn-mus LD50:47 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),833.
9.    

orl-rbt LD50:530 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),1542.

Medazepam hydrochloride Consensus Reports

 Medazepam hydrochloride (CAS NO.2898-11-5)  was reported in KSRNAM Kiso to Rinsho. Clinical Report.

Medazepam hydrochloride Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx.

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