Mefloquine hydrochloride supplier

Name
Mefloquine hydrochloride
EINECS 257-412-0
CAS No. 51773-92-3
Article Data1
CAS DataBase
Density 1.383g/cm3
Solubility DMSO: 38 mg/mL
Melting Point 250-254oC
Formula C₁₇H₁₆F₆N₂O^.HCl
Boiling Point 415.7oC at 760mmHg
Molecular Weight 414.778
Flash Point 205.2oC
Transport Information
Appearance white solid
Safety
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms 4-Quinolinemethanol,a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel- (9CI);4-Quinolinemethanol, a-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (R*,S*)-(?à)-;4-Quinolinemethanol, a-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (R*,S*)-;Loriam;Mefloquin hydrochloride;NSC 157387;Ro21-5998/001;
PSA 45.15000
LogP 5.57870

Mefloquine hydrochloride Specification

The IUPAC name of Mefloquine hydrochloride is [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol hydrochloride. With the CAS registry number 51773-92-3, it is also named as DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride. The classification codes are Antimalarial; Drug / Therapeutic Agent; Human Data. The other registry number is 68682-28-0. It is white solid which is harmful if swallowed.

The other characteristics of this product can be summarized as: (1)H-Bond Donor: 3; (2)H-Bond Acceptor: 9; (3)Rotatable Bond Count: 2; (4)Exact Mass: 414.09336; (5)MonoIsotopic Mass: 414.09336; (6)Topological Polar Surface Area: 45.2; (7)Heavy Atom Count: 27; (8)Formal Charge: 0; (9)Complexity: 483; (10)Isotope Atom Count: 0; (11)Undefined Atom StereoCenter Count: 2; (12)Covalently-Bonded Unit: Count 2.

Preparation of Mefloquine hydrochloride: It can be obtained by (2,8-bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanone. This reaction needs reagents H₂, HCl, catalytic agent PtO₂ and solvent methanol, ethanol. The reaction time is 5.5 hours. The yield is 80%.

Uses of Mefloquine hydrochloride: It is a phospholipid-interacting antimalarial drug (antimalarials). And it is very effective against plasmodium falciparum with very few side effects.

People can use the following data to convert to the molecule structure.
1. Smiles: c12c(c(cc(n2)C(F)(F)F)[C@@H]([C@H]2CCCCN2)O)cccc1C(F)(F)F.Cl
2. InChI: InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	11mg/kg/2W-I (11mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Annals of Internal Medicine. Vol. 114, Pg. 994, 1991.
man	TDLo	oral	18mg/kg/5W-I (18mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: GENERAL ANESTHETIC	Annals of Internal Medicine. Vol. 117, Pg. 1058, 1992.
man	TDLo	oral	96mg/kg/52D-I (96mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT BEHAVIORAL: AGGRESSION	Archives of Internal Medicine. Vol. 154, Pg. 2360, 1994.
rat	LD50	intraperitoneal	130mg/kg (130mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Acta Tropica. Vol. 37, Pg. 232, 1980.
rat	LD50	oral	880mg/kg (880mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Acta Tropica. Vol. 37, Pg. 232, 1980.
women	TDLo	oral	15mg/kg/3W-I (15mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Medical Journal of Australia. Vol. 161, Pg. 453, 1994.

Product Name

Mefloquine hydrochloride

Mefloquine hydrochloride Specification

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