Product Name

  • Name

    METHDILAZINE HYDROCHLORIDE (200 MG)

  • EINECS
  • CAS No. 1229-35-2
  • Density g/cm3
  • Solubility
  • Melting Point 187.5-189°
  • Formula C18H20 N2 S . Cl H
  • Boiling Point 430.4°Cat760mmHg
  • Molecular Weight 332.92
  • Flash Point 214.1°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. Experimental reproductive effects. An antihistamine. When heated to decomposition it emits very toxic fumes of NOx and HCl.
  • Risk Codes
  • Molecular Structure Molecular Structure of 1229-35-2 (METHDILAZINE HYDROCHLORIDE (200 MG))
  • Hazard Symbols
  • Synonyms 10H-Phenothiazine,10-[(1-methyl-3-pyrrolidinyl)methyl]-, monohydrochloride (9CI); Phenothiazine,10-[(1-methyl-3-pyrrolidinyl)methyl]-, monohydrochloride (8CI); Dilosyn;Disyncran; Methdilazine hydrochloride; Methdilazine monohydrochloride; NSC169091; Tacaryl; Tacaryl hydrochloride
  • PSA 31.78000
  • LogP 5.04590

Methdilazine hydrochloride Chemical Properties

IUPAC Name: 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride
Synonyms: 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine hydrochloride (1:1) ; 10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine hydrochloride ; 10-[(1-Methylpyrrolidin-3-yl)methyl]-10H-phenothiazine hydrochloride ; 10-[(1-Methylpyrrolidin-3-yl)methyl]-10H-phenothiazine hydrochloride (1:1) ; 10H-Phenothiazine, 10-[(1-Methyl-3-pyrrolidinyl)methyl]-, hydrochloride (1:1)
CAS NO: 1229-35-2
Molecular Formula of Methdilazine hydrochloride (CAS NO.1229-35-2) : C18H21ClN2S
Molecular Weight of Methdilazine hydrochloride (CAS NO.1229-35-2) : 332.89074
Molecular Structure of Methdilazine hydrochloride (CAS NO.1229-35-2) :
EINECS: 214-967-3
Mol File: 1229-35-2.mol
Flash Point: 214.1 °C
Enthalpy of Vaporization: 68.58 kJ/mol
Boiling Point: 430.4 °C at 760 mmHg
Vapour Pressure: 1.3E-07 mmHg at 25°C
General Description White microcrystalline powder with a slight odor. pH (1% aqueous solution) 4.8-6.
Air & Water Reactions: Water soluble. pH (1% aqueous solution) 4.8-6 .

Methdilazine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 25mg/kg (25mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
guinea pig LD50 oral 263mg/kg (263mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LD50 oral 190mg/kg (190mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LDLo intramuscular 300mg/kg (300mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
mouse LDLo intravenous 25mg/kg (25mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
rabbit LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
rat LD50 oral 260mg/kg (260mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
rat LDLo intraperitoneal 75mg/kg (75mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
rat LDLo intravenous 22mg/kg (22mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.

 

Methdilazine hydrochloride Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. Experimental reproductive effects. An antihistamine. When heated to decomposition it emits very toxic fumes of NOx and HCl.

Methdilazine hydrochloride Specification

Reactivity Profile: Methdilazine hydrochloride (200 MG) is sensitive to exposure to light. An acidic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

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