Product Name

  • Name

    Methyclothiazide

  • EINECS 205-172-2
  • CAS No. 135-07-9
  • Density 1.613 g/cm3
  • Solubility 50mg/L(room temperature)
  • Melting Point 223-225oC
  • Formula C9H11Cl2N3O4S2
  • Boiling Point 597.928 °C at 760 mmHg
  • Molecular Weight 360.242
  • Flash Point 315.416 °C
  • Transport Information
  • Appearance white crystal powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 135-07-9 (Methyclothiazide)
  • Hazard Symbols
  • Synonyms 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide;6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-2H-1,2,4-benzothiadiazine1,1-dioxide;Aquatensen;Ciba 7272-Su;Duretic;Enduron;Enduronum;Eutron;Methyclothiazid;Methyclothiazide;Methycyclothiazide;Methylcyclothiazide;NSC110431;Naturon;
  • PSA 126.33000
  • LogP 3.53610

Methyclothiazide Chemical Properties

Product Name: Methylcyclothiazide (CAS NO.135-07-9)


Molecular Formula: C9H11Cl2N3O4S2
Molecular Weight: 360.24g/mol
Mol File: 135-07-9.mol
Einecs: 205-172-2
Appearance: White crystal powder
Melting Point: 223-225°C
Boiling point: 597.9 °C at 760 mmHg
Flash Point: 315.4 °C
Density: 1.613 g/cm3
Solubility: Easily soluble in acetone
Surface Tension: 55.1 dyne/cm
Enthalpy of Vaporization: 89.05 kJ/mol
Vapour Pressure: 2.93E-14 mmHg at 25°C
XLogP3: 1.4
H-Bond Donor: 2
H-Bond Acceptor: 7

Methyclothiazide Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 870mg/kg (870mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969.
mouse LD50 intravenous 400mg/kg (400mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 825, 1982.
rat LD50 intraperitoneal 2gm/kg (2000mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 825, 1982.

Methyclothiazide Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−.

Methyclothiazide Specification

 Methylcyclothiazide ,its CAS NO. is 135-07-9,the synonyms is 2-Methyl-,1,1-dioxide ; 4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(chloromethyl)-3,4-dihydro-2h-2 ; 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2,4-benzothiadiazine-7-sul ; 6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine ; 6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazin ; Aquatensen;ciba7272-su ; Duretic .

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