Product Name

  • Name

    Methyl L-prolinate hydrochloride

  • EINECS 218-363-0
  • CAS No. 2133-40-6
  • Article Data134
  • CAS DataBase
  • Density 1.055 g/cm3
  • Solubility
  • Melting Point 69-71 °C(lit.)
  • Formula C6H12ClNO2
  • Boiling Point 169.9 °C at 760 mmHg
  • Molecular Weight 165.62
  • Flash Point 56.5 °C
  • Transport Information
  • Appearance crystalline
  • Safety 26-37/39
  • Risk Codes 36/38
  • Molecular Structure Molecular Structure of 2133-40-6 (Methyl L-prolinate hydrochloride)
  • Hazard Symbols IrritantXi
  • Synonyms L-Proline,methyl ester, hydrochloride (9CI);Proline, methyl ester, hydrochloride, L-(6CI,7CI,8CI);(2S)-(Methoxycarbonyl)pyrrolidine hydrochloride;(S)-Methylpyrrolidine-2-carboxylate hydrochloride;(S)-Pyrrolidine-2-carboxylic acid methyl ester hydrochloride;L-Proline methyl ester monohydrochloride;Methyl proline hydrochloride;H-Pro-OMe.HCl;H-Pro-OMe·HCl;L-Proline, methylester, hydrochloride (1:1);
  • PSA 38.33000
  • LogP 1.04220

Synthetic route

methanol
67-56-1

methanol

L-proline
147-85-3

L-proline

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With thionyl chloride for 1.5h; Heating;100%
With hydrogenchloride for 4h; Ambient temperature;100%
With thionyl chloride for 1.5h; Heating;100%
L-proline
147-85-3

L-proline

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With thionyl chloride In methanol at 20℃;100%
With sulfuryl dichloride; trimethyl orthoformate In methanol
With sulfuryl dichloride; trimethyl orthoformate In methanol
With sulfuryl dichloride; trimethyl orthoformate In methanol
N-carbobenzyloxy-L-proline methyl ester
5211-23-4

N-carbobenzyloxy-L-proline methyl ester

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol; ethyl acetate at 80℃; under 750.075 Torr;99%
(S)-N-(tert-butoxycarbonyl)proline methyl ester
59936-29-7

(S)-N-(tert-butoxycarbonyl)proline methyl ester

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With aluminium chloride doped on a neutral alumina for 0.0166667h; Irradiation;88%
With thionyl chloride In methanol at 0 - 75℃; for 1.5h;86%
With hydrogenchloride In ethyl acetate at 15℃; for 2h;
methanol
67-56-1

methanol

1-(tert-butoxycarbonyl)-L-proline
15761-39-4

1-(tert-butoxycarbonyl)-L-proline

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
Stage #1: methanol; 1-(tert-butoxycarbonyl)-L-proline With thionyl chloride at 70℃; for 7.5h; Inert atmosphere; Cooling with ice;
Stage #2: With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 0.0833333h; Inert atmosphere;		88%
Stage #1: methanol; 1-(tert-butoxycarbonyl)-L-proline With thionyl chloride at 70℃; for 7.5h; Cooling with ice;
Stage #2: With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 0.0833333h;		88%
methanol
67-56-1

methanol

L-proline
147-85-3

L-proline

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With thionyl chloride Ambient temperature;
methanol
67-56-1

methanol

proline acid chloride
175446-63-6

proline acid chloride

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

L-proline
147-85-3

L-proline

methyl iodide
74-88-4

methyl iodide

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
Stage #1: L-proline With thionyl chloride
Stage #2: methyl iodide
L-proline
147-85-3

L-proline

3-CH3O-phenyl halide

3-CH3O-phenyl halide

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2
View Scheme
methyl (2S)-pyrrolidine carboxylate
2577-48-2

methyl (2S)-pyrrolidine carboxylate

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water
carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

L-proline
147-85-3

L-proline

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Conditions
ConditionsYield
With bis(trichloromethyl) carbonate at -5 - 30℃; for 9h;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

(S)-N-(tert-butoxycarbonyl)proline methyl ester
59936-29-7

(S)-N-(tert-butoxycarbonyl)proline methyl ester

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 18℃; for 15h;100%
With triethylamine In dichloromethane for 1h; Inert atmosphere;99%
Stage #1: L-proline methyl ester monohydrochloride With triethylamine In dichloromethane at 0℃; for 0.25h;
Stage #2: di-tert-butyl dicarbonate With dmap at 0℃; for 3.5h;		98%
BOC-O-benzyl-L-serine
23680-31-1

BOC-O-benzyl-L-serine

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Boc-(OBzl)Ser-Pro-OMe
76947-97-2

Boc-(OBzl)Ser-Pro-OMe

Conditions
ConditionsYield
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 24h; Inert atmosphere;100%
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran; water at 0℃;87%
With 4-methyl-morpholine; Isopropenyl chloroformate; triethylamine 1.) THF, RT, 4 min; 2.) THF, RT, 2.5 h; Yield given. Multistep reaction;
With 4-methyl-morpholine; Isopropenyl chloroformate; N-ethyl-N,N-diisopropylamine 1.) THF, 4 min; 2.) THF, 3 h, r.t.; Yield given. Multistep reaction;
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Veratric acid
93-07-2

Veratric acid

N-(3,4-Dimethoxybenzoyl)-2-pyrrolidincarbonsaeuremethylester
87664-50-4

N-(3,4-Dimethoxybenzoyl)-2-pyrrolidincarbonsaeuremethylester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;100%
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 60h;29%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

N-[3β-hydroxy-lup-20(29)-en-28-oyl]-8-aminooctanoic acid
150841-42-2

N-[3β-hydroxy-lup-20(29)-en-28-oyl]-8-aminooctanoic acid

(S)-1-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoyl}-pyrrolidine-2-carboxylic acid methyl ester
174740-16-0

(S)-1-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoyl}-pyrrolidine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 15h; Ambient temperature;100%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Allyl chloroformate
2937-50-0

Allyl chloroformate

1-allyl 2-methyl (S)-pyrrolidine-1,2-dicarboxylate
126408-55-7

1-allyl 2-methyl (S)-pyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 0.666667h;100%
With pyridine In dichloromethane at 0 - 20℃;99%
1-Methyl-2-pyrrolecarboxylic acid
6973-60-0

1-Methyl-2-pyrrolecarboxylic acid

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

methyl (2S)-N-(1-methyl-2-pyrrolylcarbonyl)pyrrolidin-2-carboxylate
594816-52-1

methyl (2S)-N-(1-methyl-2-pyrrolylcarbonyl)pyrrolidin-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;100%
4-(benzyloxy)-3-methoxybenzoic acid
1486-53-9

4-(benzyloxy)-3-methoxybenzoic acid

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

methyl (2S)-N-(4-benzyloxy-3-methoxybenzoyl)pyrrolidin-2-carboxylate
849795-68-2

methyl (2S)-N-(4-benzyloxy-3-methoxybenzoyl)pyrrolidin-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;100%
6-(tert-butoxycarbonylamino)hexanoic acid
6404-29-1

6-(tert-butoxycarbonylamino)hexanoic acid

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Boc-6-aminocaproyl-L-proline methyl ester
870753-90-5

Boc-6-aminocaproyl-L-proline methyl ester

Conditions
ConditionsYield
Stage #1: 6-(tert-butoxycarbonylamino)hexanoic acid With pivaloyl chloride; triethylamine In dichloromethane at 0℃; for 1h;
Stage #2: L-proline methyl ester monohydrochloride With triethylamine In dichloromethane at 0 - 20℃; for 3h;		100%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(S)-Pyrrolidine-2-carboxylic acid methyl ester; compound with trifluoro-acetic acid
42460-90-2

(S)-Pyrrolidine-2-carboxylic acid methyl ester; compound with trifluoro-acetic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 25℃; for 12h;100%
2-deoxy-2-{[(phenylmethyloxy)carbonyl]amino}-D-glycero-hexopyranose

2-deoxy-2-{[(phenylmethyloxy)carbonyl]amino}-D-glycero-hexopyranose

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

1,2-dideoxy-1-[(2S)-2-(methoxycarbonyl)-1-pyrrolidinyl]-2-[[(phenylmethoxy)carbonyl]amino]-D-glycero-hexitol

1,2-dideoxy-1-[(2S)-2-(methoxycarbonyl)-1-pyrrolidinyl]-2-[[(phenylmethoxy)carbonyl]amino]-D-glycero-hexitol

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol at 64℃; for 14h;100%
With sodium cyanoborohydride In methanol at 64℃; for 14h;100%
With sodium cyanoborohydride In methanol at 64℃; for 14h;100%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

benzyl bromide
100-39-0

benzyl bromide

N-benzyl-(S)-proline methyl ester
113304-84-0, 127986-89-4

N-benzyl-(S)-proline methyl ester

Conditions
ConditionsYield
Stage #1: L-proline methyl ester monohydrochloride In dichloromethane
Stage #2: benzyl bromide at 25℃; for 8h;		100%
With triethylamine In dichloromethane at 20℃; Inert atmosphere; Cooling;91%
With triethylamine In dichloromethane at 20℃; for 17h; Inert atmosphere; Cooling;91%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

(S)-proline methyl ester hydroiodide
1061351-48-1

(S)-proline methyl ester hydroiodide

Conditions
ConditionsYield
With sodium iodide In methanol at 20℃; for 1h;100%
6-(2-methoxyphenyl)pyrimidin-4-amine
1142004-97-4

6-(2-methoxyphenyl)pyrimidin-4-amine

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

1-[6-(2-methoxy-phenyl)-pyrimidin-4-ylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester
1142005-59-1

1-[6-(2-methoxy-phenyl)-pyrimidin-4-ylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; phenyl chloroformate In 1,4-dioxane; dichloromethane at -78 - 70℃;100%
4-(pyridin-2-yloxy)benzoic acid
51363-00-9

4-(pyridin-2-yloxy)benzoic acid

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

(S)-methyl 1-(4-(pyridin-2-yloxy)benzoyl)pyrrolidine-2-carboxylate

(S)-methyl 1-(4-(pyridin-2-yloxy)benzoyl)pyrrolidine-2-carboxylate

Conditions
ConditionsYield
Stage #1: 4-(pyridin-2-yloxy)benzoic acid With oxalyl dichloride In dichloromethane at 0 - 20℃; for 1h;
Stage #2: L-proline methyl ester monohydrochloride With triethylamine In dichloromethane at 0 - 20℃; for 12h;		100%
2-deoxy-2-{[(phenylmethyloxy)carbonyl]amino}-D-glycero-hexopyranose

2-deoxy-2-{[(phenylmethyloxy)carbonyl]amino}-D-glycero-hexopyranose

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

1,2-dideoxy-1-[(2S)-2-(methoxycarbonyl)-1-pyrrolidinyl]-2-[[(phenylmethoxy)carbonyl]amino]-D-glycero-hexitol

1,2-dideoxy-1-[(2S)-2-(methoxycarbonyl)-1-pyrrolidinyl]-2-[[(phenylmethoxy)carbonyl]amino]-D-glycero-hexitol

Conditions
ConditionsYield
With methanol; sodium cyanoborohydride at 64℃; for 14h;100%
C22H39N3O4*(x)ClH

C22H39N3O4*(x)ClH

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

C28H48N4O5*(x)ClH

C28H48N4O5*(x)ClH

Conditions
ConditionsYield
Stage #1: C22H39N3O4*(x)ClH; L-proline methyl ester monohydrochloride With 4-methyl-morpholine; diethyl cyanophosphonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
Stage #2: With hydrogenchloride In water; acetonitrile		100%
3-acetylsulfanyl-propionic acid
41345-70-4

3-acetylsulfanyl-propionic acid

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

methyl (S)-1-(3-(acetylthio)propanoyl)pyrrolidine-2-carboxylate

methyl (S)-1-(3-(acetylthio)propanoyl)pyrrolidine-2-carboxylate

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;100%
S-acetyl-4-mercaptobutyric acid
101421-82-3

S-acetyl-4-mercaptobutyric acid

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

methyl (S)-1-(4-(acetylthio)butanoyl)pyrrolidine-2-carboxylate

methyl (S)-1-(4-(acetylthio)butanoyl)pyrrolidine-2-carboxylate

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;100%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

monomethyl monopotassium malonate
38330-80-2

monomethyl monopotassium malonate

(S)-methyl 1-(3-methoxy-3-oxopropanoyl)pyrrolidine-2-carboxylate
150884-88-1

(S)-methyl 1-(3-methoxy-3-oxopropanoyl)pyrrolidine-2-carboxylate

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;100%
3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride
188440-21-3

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

N-[(3-Bromomethyl-2,4-dichlorophenyl)sulfonyl]-(D,L)-proline Methyl Ester
188440-24-6

N-[(3-Bromomethyl-2,4-dichlorophenyl)sulfonyl]-(D,L)-proline Methyl Ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃;100%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

2-Methoxybenzoic acid
579-75-9

2-Methoxybenzoic acid

N-(2-Methoxybenzoyl)-L-proline methyl ester
142351-09-5

N-(2-Methoxybenzoyl)-L-proline methyl ester

Conditions
ConditionsYield
With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide In tetrahydrofuran Ambient temperature;99%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid
402958-96-7

(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid

(S)-methyl 1-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetyl)pyrrolidine-2-carboxylate

(S)-methyl 1-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetyl)pyrrolidine-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane for 2h;99%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

Diphenylphosphinic chloride
1499-21-4

Diphenylphosphinic chloride

(S)-1-(Diphenyl-phosphinoyl)-pyrrolidine-2-carboxylic acid methyl ester
608533-84-2

(S)-1-(Diphenyl-phosphinoyl)-pyrrolidine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: L-proline methyl ester monohydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 0.5h; Inert atmosphere;
Stage #2: Diphenylphosphinic chloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 36h; Inert atmosphere;		99%
4-Fluorobenzenesulfonyl chloride
349-88-2

4-Fluorobenzenesulfonyl chloride

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

methyl (S)-1-((4-fluorophenyl)sulfonyl)pyrrolidine-2-carboxylate

methyl (S)-1-((4-fluorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Conditions
ConditionsYield
With 4-methyl-morpholine In dichloromethane at 20℃; for 5h; Inert atmosphere;99%
3,4-dichlorobenzenesulphonyl chloride
98-31-7

3,4-dichlorobenzenesulphonyl chloride

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

methyl (S)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

methyl (S)-1-((3,4-dichlorophenyl)sulfonyl)pyrrolidine-2-carboxylate

Conditions
ConditionsYield
With 4-methyl-morpholine In dichloromethane at 20℃; for 5h; Inert atmosphere;99%
2,6-bis(chloromethyl)-4-(prop-2-yn-1-yloxy)pyridine

2,6-bis(chloromethyl)-4-(prop-2-yn-1-yloxy)pyridine

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

C20H25N3O5

C20H25N3O5

Conditions
ConditionsYield
Stage #1: 2,6-bis(chloromethyl)-4-(prop-2-yn-1-yloxy)pyridine; L-proline methyl ester monohydrochloride With potassium carbonate; potassium iodide In acetonitrile at 45℃; for 12h;
Stage #2: With sodium hydroxide In methanol; water at 40℃; for 5h;		99%
L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline
154057-56-4

3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline

((2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)-L-proline

((2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)-L-proline

Conditions
ConditionsYield
Stage #1: L-proline methyl ester monohydrochloride; 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;
Stage #2: With potassium hydroxide In tetrahydrofuran; water at 50℃;		99%

Methyl L-prolinate hydrochloride Chemical Properties

The Molecular Structure of L-Proline methyl ester hydrochloride (CAS NO.2133-40-6):

Empirical Formula: C6H12ClNO2
Molecular Weight: 165.618 
IUPAC Name: methyl pyrrolidine-2-carboxylate hydrochloride    
Appearance: Crystalline
Nominal Mass: 165 Da
Average Mass: 165.618 Da
Monoisotopic Mass: 165.055656 Da 
Flash Point: 56.5 °C 
Melting Point: 69-71 °C 
Enthalpy of Vaporization: 40.63 kJ/mol
Boiling Point: 169.9 °C at 760 mmHg
Vapour Pressure: 1.51 mmHg at 25°C 
Synonyms: H-l-pro-ome hcl ; H-pro-ome hcl ; Methyl l-prolinate hydrochloride ; L-pyrrolidine-2-carboxylic acid methyl ester hcl ; L-proline methyl ester hydrochloride ; L-proline methyl ester hydrochloride salt ; Proline-ome hcl ; L-proline methyl ester hcl     
Product Categories: AMINOACIDS DERIVATIVES;Esters;Pyrrolidines;Amino Acid Derivatives;Amino Acids;Proline [Pro, P];Amino Acids and Derivatives;Amino hydrochloride;Peptide Synthesis;Amino Acid Derivatives;Proline

Methyl L-prolinate hydrochloride Toxicity Data With Reference

RTECS#: CAS# 2133-40-6 unlisted.
LD50/LC50: Not available.
Carcinogenicity: l-PROLINE methyl ester hydrochloride -Not listed by ACGIH, IARC, or NTP.

Methyl L-prolinate hydrochloride Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/38 
R36/38: Irritating to eyes and skin
Safety Statements: 26-37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
F: 3-8-10-21
Hazard Note: Harmful

Methyl L-prolinate hydrochloride Specification

Conditions to Avoid: Incompatible materials, dust generation, excess HEAT, exposure to moist air or WATER.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Hydrogen chloride, NITROGEN oxides, CARBON monoxide, irritating and toxic fumes and gases, CARBON dioxide.
Hazardous Polymerization: Has not been reported

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