Product Name

  • Name

    METHYL PHOSPHONOTHIOIC DICHLORIDE

  • EINECS
  • CAS No. 676-99-3
  • Article Data16
  • CAS DataBase
  • Density 1,384 g/cm3
  • Solubility
  • Melting Point -37oC
  • Formula CH3 F2 O P
  • Boiling Point 98-99°C
  • Molecular Weight 100.005
  • Flash Point
  • Transport Information
  • Appearance
  • Safety Poison by inhalation and intravenous routes. When heated to decomposition it emits toxic fumes of POx and F−. See also FLUORIDES.
  • Risk Codes R34; R36/37/38
  • Molecular Structure Molecular Structure of 676-99-3 (METHYL PHOSPHONOTHIOIC DICHLORIDE)
  • Hazard Symbols
  • Synonyms Phosphonicdifluoride, methyl- (6CI,7CI,8CI,9CI); Difluoromethylphosphine oxide; Methyldifluorophosphite; Methylphosphonic difluoride; Methylphosphonyldifluoride
  • PSA 26.88000
  • LogP 1.74830

Methylphosphonyl difluoride Chemical Properties

The IUPAC name of Methylphosphonyl difluoride (CAS NO.676-99-3): Difluorophosphorylmethane
Synonyms: Difluoro ; Difluoromethylphosphine oxide ; Difluoromethylphosphineoxide ; Methyl difluorophosphite ; Methyldifluorophosphite ; Methylphosphonic difluoride ; Methylphosphonicaciddifluoride ; Methyl-phosphonicaciddifluoride
CAS: 676-99-3 
Molecular Weight: 100.004487 g/mol
Molecular Formula: CH3F2OP
Molecular Structure:

Index of Refraction: 1.276 
Density: 1.248 g/cm3 
Boiling Point: 55.4 °C at 760 mmHg

Methylphosphonyl difluoride Toxicity Data With Reference

The toxicity of Methylphosphonyl difluoride (CAS NO.676-99-3):

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LCLo inhalation 1842mg/m3/30M (1842mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
dog LD50 intravenous 25800ug/kg (25.8mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
guinea pig LCLo inhalation 1600mg/m3 (1600mg/m3)   Toxicologist. Vol. 4, Pg. 22, 1984.
monkey LCLo inhalation 2608mg/m3/30M (2608mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: AGGRESSION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
monkey LD50 intravenous 26900ug/kg (26.9mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
mouse LCLo inhalation 1842mg/m3/30M (1842mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
mouse LD50 intravenous 114mg/kg (114mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
rat LCLo inhalation 1842mg/m3/30M (1842mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
rat LD50 intravenous 13700ug/kg (13.7mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,

Methylphosphonyl difluoride Consensus Reports

Reported in EPA TSCA Inventory.

Methylphosphonyl difluoride Safety Profile

The Risk Statements Methylphosphonyl difluoride (CAS NO.676-99-3):
R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:S23:Do not breathe vapour. S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Poison by inhalation and intravenous routes. When heated to decomposition it emits toxic fumes of POx and F−. See also FLUORIDES.

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